Interrelationship of dendritic cells, type 1 interferon system, regulatory T cells and toll-like receptors and their role in lichen planus and lupus erythematosus – A literature review

Autoimmune comorbid diseases associated with lichen planus: a nationwide case–control study

“…The antigen that triggers this inflammatory response is still unknown . Autoimmunity has been proposed to play a key role in the pathogenesis . Chang et al .…”

“…1 Autoimmunity has been proposed to play a key role in the pathogenesis. 3 Chang et al 4 have demonstrated that patients with oral LP have higher frequency of circulating autoantibodies, including antinuclear (ANA), antithyroglobulin (TGA) and antithyroid microsomal autoantibodies (TMA), than healthy control subjects. The role of these autoantibodies in the pathogenesis of LP remains unclear.…”

MicroRNA-663 induces immune dysregulation by inhibiting TGF-β1 production in bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus

“…19 In contrast, regulatory T (T reg ) cells appear to inhibit B-cell responses by suppressing the activities of T fh cells, and by doing so, prevent lupus development. 20,21 The imbalance between T cell subsets is important in autoimmune disease including SLE pathogenesis, 22 but the underlying mechanisms remain unclear. In this study, using comparative miRNAs profilings in BMSCs, we identified miR-663 as a candidate miRNA for SLE pathogenesis.…”

Expressão gênica do receptor Toll-like 2 e pesquisa das variantes rs1898830 e rs4696480 em pacientes com líquen plano oral

“…A ativação do TLR2 pode interferir em sua atividade inibitória da reposta imunológica Th1, pois sabe-se que a ativação do TLR2 bloqueia a atividade imunossupressora dos linfócitos T reguladores e induz a diferenciação de linfócitos em células Th efetoras pró-inflamatórias (Trucci et al, 2013).…”

“…Poucos estudos avaliaram a expressão gênica ou proteica dos TLR no LPO (Sinon et al, 2016;Adami et al, 2014;Stanimirovic et al, 2013;Trucci et al, 2013;Kho et al, 2013;Ge et al, 2012;El Tawady;Rashed, 2012;Siponen et al, 2012;Janardhanam et al, 2012;Ohno et al, 2011;Srinivasan et al, 2008;Zunt et al, 2009). Especificamente em relação ao TLR2, apenas seis estudos fizeram esta avaliação, e os resultados são algumas vezes contraditórios (Srinivasan et al, 2007;Janardhanam et al, 2012;Ohno et al, 2012;Kho et al, 2013;Adami et al, 2014;Sinon et al, 2016).…”