Interrelationship of blood transfusion, non-A, non-B hepatitis and hepatocellular carcinoma: Analysis by detection of antibody to hepatitis C virus

Kiyosawa, Kendo; Sodeyama, Takeshi; Tanaka, Eiji; Gibo, Yukio; Yoshizawa, Kaname; Nakano, Yoshitaka; Furuta, Seiichi; Akahane, Yoshihiro; Nishioka, Kusuya; Purcell, Robert H.; Alter, Harvey J.

doi:10.1002/hep.1840120409

Cited by 1,172 publications

(642 citation statements)

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“…Kiyosawa et al found in their prospective study that the mean interval between the blood transfusion (the presumed source of HCV infection) and the diagnosis of HCC was approximately 29 years in the 21 patients in their study. 5 In the current study, the mean age of patients at the time of HCC diagnosis was 64.4 years (standard deviation of 5.8 years; range, 53-74 years) and only 4 patients were age Ͻ 60 years. The current study data and those of Kiyosawas et al 5 indicate that it is rare to find HCC in a patient with posttransfusion hepatitis C who is age Ͻ 60 years.…”

Section: Discussionmentioning

confidence: 57%

“…5 In the current study, the mean age of patients at the time of HCC diagnosis was 64.4 years (standard deviation of 5.8 years; range, 53-74 years) and only 4 patients were age Ͻ 60 years. The current study data and those of Kiyosawas et al 5 indicate that it is rare to find HCC in a patient with posttransfusion hepatitis C who is age Ͻ 60 years. Figure 3 shows the relation between the period from blood transfusion to the diagnosis of HCC and the age of the patient at the time of blood transfusion.…”

Section: Discussionmentioning

confidence: 57%

“…The interval between HCV infection and the development of significant liver disease is reported to be very long. 1 Kiyosawa et al reported that the mean duration between blood transfusion and the diagnosis of HCC was approximately 29 years (standard deviation of 13 years) (n ϭ 21), 5 and Tong et al reported it to be 28 years (standard deviation of 11 years) (n ϭ 14). 9 This duration has been confirmed further by several investigators in other countries.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, to our knowledge, the majority of previous studies of the natural history of chronic hepatitis C faced a major limitation, namely inadequate information regarding the duration of infection. 5,6 To overcome this limitation, we studied 469 patients with chronic HCV who received a single blood transfusion by which the infection likely was acquired.…”

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Impact of aging on the development of hepatocellular carcinoma in patients with posttransfusion chronic hepatitis C

Hamada

Yatsuhashi

Yano

et al. 2002

Cancer

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BACKGROUNDHepatitis C virus (HCV) infection is a heterogeneous disease, the natural history of which remains controversial. There is solid evidence that chronic HCV infection is responsible for the occurrence of hepatocellular carcinoma (HCC). The aim of the current cohort study was to determine the rate of the development of HCC from the time of primary HCV infection and to assess the risk factors for the development of HCC in chronic posttransfusion hepatitis C patients.METHODSFour hundred sixty‐nine patients with clinically compensated HCV, who had undergone a single blood transfusion comprised the current study cohort. Patients with other risk factors for chronic liver disease were excluded. All patients were referred to the liver center at the National Nagasaki Medical Center between December 1980 and December 1998 and were followed prospectively until the end of the analysis (June 2000).RESULTSFollow‐up data were obtained for 445 patients. The mean duration from HCV infection to the end of the observation was 28 years. Fifty‐two patients (11.1%) progressed to HCC. The mean duration from the time of blood transfusion to the diagnosis of HCC was 31 years. Multivariate Cox regression analyses revealed age, fibrosis, duration from HCV infection to study entry, and alcohol consumption to be the independent factors affecting the development of HCC. The risk of developing HCC in patients age ≥ 56 years was increased 7.8‐fold compared with that in patients age < 56 years. The mean age of patients at the time of HCC diagnosis was 65 years (range, 58–79 years).CONCLUSIONSAt the time of diagnosis, 92% of the 52 HCC patients were age > 60 years and 38 of the HCC patients (73%) were in their 60s. There was a significantly negative correlation between the duration from HCV infection to the development of HCC and the age of the patient at the time of infection (correlation coefficient = 0.702; P < 0.0001; Y = 61.1–0.82X), indicating that the age of patients, rather than the duration of HCV infection, is more significant for HCC development in patients with posttransfusion HCV. Moreover, these data may contribute to the design of an optimal follow‐up schedule for patients with posttransfusion HCV. Cancer 2002;95:331–9. © 2002 American Cancer Society.DOI 10.1002/cncr.10662

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Impact of aging on the development of hepatocellular carcinoma in patients with posttransfusion chronic hepatitis C

Hamada

Yatsuhashi

Yano

et al. 2002

Cancer

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“…[1][2][3][4] There is a substantial amount of evidence suggesting that host genetic differences influence recovery from HCV infection. Even when a large number of persons have been accidentally infected by the same viral inoculum, some recover while others develop viral persistence.…”

Section: Introductionmentioning

confidence: 99%

MICA and recovery from hepatitis C virus and hepatitis B virus infections

et al. 2004

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The polymorphic MHC class I chain-related A (MICA) gene encodes a ligand that has different binding affinities for the NKG2D activating receptor of CD8 þ T cells and natural killer (NK) cells. We hypothesized that MICA heterogeneity would affect recovery from hepatitis C virus (HCV) and hepatitis B virus (HBV) infections. To test the hypothesis, we initially typed known MICA polymorphisms for 228 persons who cleared HCV infection and 442 persons with persistent hepatitis C matched on other factors affecting viral persistence. Although MICA*015 was detected more than two-fold more often in persons with viral clearance (odds ratio 0.36, 95% confidence interval ¼ 0.19, 0.80), it occurred in fewer than 5% of the study population. In a similar analysis of 442 persons with chronic hepatitis B and 768 matched controls who recovered, MICA*015 was detected in 2.0% of persons with chronic hepatitis B and only 0.9% of controls. No significant associations were detected with other MICA polymorphisms. While further investigation may reveal a structural basis of the MICA*015 associations, these data provide little support for the hypothesis that differential distribution of MICA alleles substantially affects recovery from HCV and HBV infections.

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The Digestive System

Cocchiarella,

Andersson

2001

AMA Guides® to the Evaluation of Permanent Impairment, Fifth Edition, 2001

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Interrelationship of blood transfusion, non-A, non-B hepatitis and hepatocellular carcinoma: Analysis by detection of antibody to hepatitis C virus

Cited by 1,172 publications

References 19 publications

Impact of aging on the development of hepatocellular carcinoma in patients with posttransfusion chronic hepatitis C

Impact of aging on the development of hepatocellular carcinoma in patients with posttransfusion chronic hepatitis C

MICA and recovery from hepatitis C virus and hepatitis B virus infections

The Digestive System

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