Interrelationship Between Periapical Lesion and Systemic Metabolic Disorders

Sasaki, Hajime; Hirai, Kazumasa; Martins, Christine Men; Furusho, Hisako; Battaglino, Ricardo A.; Hashimoto, Kazuhito

doi:10.2174/1381612822666160216145107

Cited by 85 publications

(90 citation statements)

References 194 publications

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“…However, there seems to be a void in the scientific literature to specifically support such hypothesis. Nonetheless, the subsequent periapical periodontitis decreases insulin sensitivity [42,78].…”

Section: Cariesmentioning

confidence: 99%

IDF Diabetes Atlas: Diabetes and oral health – A two-way relationship of clinical importance

Borgnakke

2019

Diabetes Research and Clinical Practice

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The current scientific evidence for the bi-directional associations between oral health and diabetes is summarized. The universal biologic mechanisms and demographic and behavioral risk drivers underlying these associations in both directions are also described. Dysglycemia, even slightly elevated blood sugar levels, adversely affects oral health, manifesting itself in several oral diseases and conditions. In the opposite direction, any oral infection with its subsequent local and systemic inflammatory responses adversely affects blood glucose levels. Moreover, painful, mobile, or missing teeth may lead to intake of soft food items representing a sub-optimal diet and hence poor nutrition, and thereby contribute to incident type 2 diabetes or to poorer glucose control in existing diabetes. Treatment of inflammation related oral conditions, such as non-surgical periodontal treatment and extraction of infected teeth, can lead to a clinically significant decrease in blood glucose levels. Attention to infectious oral diseases and referral to dental care professionals for treatment can therefore be an important novel tool for medical care professionals in preventing and managing diabetes mellitus. Dental professionals can detect unrecognized potential dysglycemia and refer for medical examination. Such interprofessional, patient centered care may contribute to improved health, wellbeing, and quality of life in people with diabetes.

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Section: Cariesmentioning

confidence: 99%

IDF Diabetes Atlas: Diabetes and oral health – A two-way relationship of clinical importance

Borgnakke

2019

Diabetes Research and Clinical Practice

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“…After excluding studies during the initial phase, 12 reviews were included for full-text assessment. A further eight reviews were excluded during the second phase (fulltext reading) because seven of them were narrative reviews, not systematic (Fouad 2003, Segura-Egea et al 2012, 2015, Lima et al 2013, Sasaki et al 2016, Holland et al 2017) and one systematic review (Khalighinejad et al 2016) did not address the aim of the current umbrella review. Finally, four systematic reviews were included (Segura-Egea et al…”

Section: Search Resultsmentioning

confidence: 99%

Association between diabetes and the outcome of root canal treatment in adults: an umbrella review

et al. 2019

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Background Diabetes mellitus is the most common metabolic disorder amongst dental patients. The association between the diabetes and the outcome of root canal treatment is unclear. Aim To conduct an umbrella review to determine whether there is an association between diabetes and the outcome of root canal treatment. Data source The protocol of the review was developed and registered in the PROSPERO database (CRD42019141684). Four electronic databases (PubMed, EBSCHOhost, Cochrane and Scopus databases) were used to perform a literature search until July 2019. Study eligibility criteria, participants and interventions Systematic reviews with or without meta‐analyses published in English assessing any outcomes of root canal treatment comparing diabetic and nondiabetic patients were included. Two reviewers were involved independently in study selection, data extraction and appraising the reviews that were included. Disagreements were resolved with the help of a third reviewer. Study appraisal and synthesis methods The quality of the reviews was assessed using the AMSTAR tool (A measurement tool to assess systematic reviews), with 11 items. Each AMSTAR item was given a score of 1 if the criterion was met, or 0 if the criterion was not met or the information was unclear. Results Four systematic reviews were included. The AMSTAR score for the reviews ranged from 5 to 7, out of a maximum score of 11, and all the systematic reviews were classified as ‘medium’ quality. Limitations Only two systematic reviews included a meta‐analysis. Only systematic reviews published in English were included. Conclusions and implications of key findings Diabetes mellitus is associated with the outcome of root canal treatment and can be considered as a preoperative prognostic factor.

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“…The pathological features of periapical periodontitis are inflammation of the apical area and destruction of bone tissue (Hernández et al, 2018, Kirkevang, Ørstavik, Bahrami, Wenzel, & Vaeth, 2017Wei, Liu, Xiong, Peng, 2018). This results in immune inflammatory responses, which involve a large number of inflammatory cells that are regulated by a variety of cytokines (Provenzano et al, 2016;Sasaki et al, 2016). Enterococcus faecalis is the main pathogen that F I G U R E 4 Expression of the critical components in the JAK2-STAT3 signaling pathway and TRAP protein in the different treatment groups.…”

Section: Discussionmentioning

confidence: 99%

JAK2‐STAT3 signaling pathway is involved in rat periapical lesions induced by Enterococcus faecalis

Wang

Jin

et al. 2019

Oral Diseases

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Objectives This study aimed to investigate the role of JAK2‐STAT3 (Janus kinase 2/signal transducer and activator of transcription 3) in periapical disease caused by Enterococcus faecalis, as well as the correlation between lipoteichoic acid (LTA) in E. faecalis and the activity of the JAK2‐STAT3 signaling pathway and osteoclast formation. Materials and Methods A rat model of periapical periodontitis induced by E. faecalis was established. Periapical bone resorption was confirmed by HE staining. The expression of JAK2, p‐JAK2, STAT3, and p‐STAT3 was assessed with immunohistochemical staining. Osteoclasts were observed through enzyme histochemical staining. LTA acted on mouse osteoclast precursor cells (RAW264.7 cells); a JAK2 inhibitor (AG490) was used to inhibit the JAK2‐STAT3 pathway in RAW264.7 cells. The expression of proteins in the JAK2‐STAT3 pathway and TRAP (tartrate resistant acid phosphatase) in RAW264.7 cells was also detected. Results Rat periapical periodontitis was successfully established and bone resorption peaked at day 21. The expression of critical components in the JAK2‐STAT3 pathway increased with the progression of inflammation. LTA promoted the differentiation of RAW264.7 cells into osteoclasts. NFATc1 was highly expressed and was inhibited by AG490. Conclusions JAK2‐STAT3 signaling pathway plays an important role in the process of periapical bone resorption and osteoclastogenesis.

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Interrelationship Between Periapical Lesion and Systemic Metabolic Disorders

Cited by 85 publications

References 194 publications

IDF Diabetes Atlas: Diabetes and oral health – A two-way relationship of clinical importance

IDF Diabetes Atlas: Diabetes and oral health – A two-way relationship of clinical importance

Association between diabetes and the outcome of root canal treatment in adults: an umbrella review

JAK2‐STAT3 signaling pathway is involved in rat periapical lesions induced by Enterococcus faecalis

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