Interrelations among the adipocytokines leptin and adiponectin, oxidative stress and aseptic inflammation markers in pre- and early-pubertal normal-weight and obese boys

Paltoglou, George; Schoina, Maria; Valsamakis, George; Salakos, N; Avloniti, Alexandra; Chatzinikolaou, Athanasios; Margeli, Alexandra; Skevaki, Chrysanthi; Papagianni, Maria; Kanaka‐Gantenbein, Christina; Papassotiriou, Ioannis; Chrousos, George P.; Fatouros, Ioannis G.; Mastorakos, George

doi:10.1007/s12020-017-1227-3

Cited by 40 publications

(39 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The mechanisms underlying the development of obesity and its associated comorbidities include hypertrophy and hyperplasia of primarily visceral adipocytes, adipose tissue inflammation, impaired extracellular matrix remodeling, and fibrosis, together with altered secretion of adipokines [11,57,58]. Chronically stressful conditions cause hypertrophy and hyperplasia of the adipocytes, alter the secretion of adipokines, and cause attraction and activation of stromal fat immune cells [59][60][61].…”

Section: Muscle Mass: Myosteatosis and Sarcopeniamentioning

confidence: 99%

See 1 more Smart Citation

Chronic stress and body composition disorders: implications for health and disease

Stefanaki

Pervanidou

Boschiero³

et al. 2018

Hormones

Self Cite

View full text Add to dashboard Cite

Recent studies have suggested that body composition is key to health and disease. First, fat tissue is a complex, essential, and highly active metabolic and endocrine organ that responds to afferent signals from traditional hormone systems and the central nervous system but also expresses and secretes factors with important endocrine, metabolic, and immune functions. Second, skeletal muscle mass is an important predictor of health in adult life, while severe mass loss has been associated with the frailty of old age. Studies have shown that skeletal muscle is also an important endocrine organ that secretes factors with autocrine, paracrine, or endocrine actions, which have been associated with inflammatory processes. Third, the bone is also a systemic endocrine regulator playing a pivotal role in health and disease. Finally, proper hydration in humans has been neglected as a health factor, especially in adults. Chronic stress and stress hormone hypersecretion alone or associated with distinct disorders, such as anxiety, depression, obesity, metabolic syndrome, autoimmune disorders, type 2 diabetes mellitus, and polycystic ovary syndrome (PCOS), have been associated with psychological and somatic manifestations, typically, increased fat mass, osteosarcopenia/frailty, cellular dehydration, and chronic systemic inflammation. This review aims to provide new insights into the newly developed concept of stress-related osteosarcopenic obesity and its prevention.

show abstract

Section: Muscle Mass: Myosteatosis and Sarcopeniamentioning

confidence: 99%

“…It is caused by an imbalance between the energy input of the diet and the body's energy demands [9][10][11]. Fat accumulation in various tissues has been implicated in many metabolic disorders, such as non-alcoholic fatty liver disease (NAFLD) or hepatosteatosis [12] and myosteatosis [13].…”

Section: Introductionmentioning

confidence: 99%

Chronic stress and body composition disorders: implications for health and disease

Stefanaki

Pervanidou

Boschiero³

et al. 2018

Hormones

Self Cite

View full text Add to dashboard Cite

show abstract

“…Reports have shown decreased levels of adiponectin in individuals with obesity [47, 48]. In pre-pubertal boys, there is a reported increase and negative association with anti-oxidation, suggesting a link between aseptic inflammation and oxidative stress and childhood obesity [49]. It has also been shown that parent stressors impact childhood obesity and African American and Hispanic children raised in single-parent households and children from low-income families were at major risk of partaking in activities, such as fast-food consumption at rates that were correlated with parent stressors [34].…”

Section: Introductionmentioning

confidence: 99%

Racial Disparities in Obesity Treatment

2018

View full text Add to dashboard Cite

Purpose of Review Obesity rates in the USA have reached pandemic levels with one third of the population with obesity in 2015–2016 (39.8% of adults and 18.5% of youth). It is a major public health concern, and it is prudent to understand the factors which contribute. Racial and ethnic disparities are pronounced in both the prevalence and treatment of obesity and must be addressed in the efforts to combat obesity. Recent Findings Disparities in prevalence of obesity in racial/ethnic minorities are apparent as early as the preschool years and factors including genetics, diet, physical activity, psychological factors, stress, income, and discrimination, among others, must be taken into consideration. A multidisciplinary team optimizes lifestyle and behavioral interventions, pharmacologic therapy, and access to bariatric surgery to develop the most beneficial and equitable treatment plans Summary The reviewed studies outline disparities that exist and the impact that race/ethnicity have on disease prevalence and treatment response. Higher prevalence and reduced treatment response to lifestyle, behavior, pharmacotherapy, and surgery, are observed in racial and ethnic minorities. Increased research, diagnosis, and access to treatment in the pediatric and adult populations of racial and ethnic minorities are proposed to combat the burgeoning obesity epidemic and to prevent increasing disparity.

show abstract

“…Despite the presence of low‐grade chronic inflammation and insulin resistance in young people, information on the inflammatory response to an acute bout of exercise in adolescents is limited. Previous studies examining the release of inflammatory mediators, IL‐6, and TNF‐α in response to an acute bout of endurance exercise have reported increases, decreases, or no changes . However, young people do not typically participate in endurance exercise, with intermittent activity being both enjoyable (important for long‐term adherence) and replicative of their physical activity patterns .…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies examining the release of inflammatory mediators, IL-6, and TNF-α in response to an acute bout of endurance exercise have reported increases, 9,10 decreases, 11 or no changes. 12,13 However, young people do not typically participate in endurance exercise, with intermittent activity being both enjoyable (important for long-term adherence) 14 and replicative of their physical activity patterns. 15 Eccentric exercise is an alternative mode of physical activity that elicits an increase in the release of pro-inflammatory cytokines (IL-6 and IL-1β) in response to the muscle damage incurred.…”

Section: Introductionmentioning

confidence: 99%

Cytokine, glycemic, and insulinemic responses to an acute bout of games‐based activity in adolescents

Dring

Cooper

Morris

et al. 2019

Scandinavian Med Sci Sports

View full text Add to dashboard Cite

An acute bout of endurance exercise in adults stimulates a same‐day anti‐inflammatory response which may affect low‐grade chronic inflammation and insulin resistance and benefit cardio‐metabolic health. The anti‐inflammatory responses to intermittent games‐based exercise and to exercise in young people beyond 2 hours post‐exercise are unknown. Thus, the purpose of the present study is to examine the anti‐inflammatory, glycemic and insulinemic response to games‐based activity in adolescents. Following ethical approval and familiarization, 39 adolescents (12.3 ± 0.7 years) completed an exercise (E) and rested (R) trial in a counterbalanced, randomized crossover design. Following a standardized breakfast, participants completed 1‐hour games‐based activity. Capillary blood samples were taken at baseline, immediately and 1 hour post‐exercise, and 30, 60 and 120 minutes following a standardized lunch. A final blood sample was taken the next morning. Data were analyzed using repeated measures ANOVA. IL‐6 concentration was higher on day one of the exercise trial (E:3.4 ± 0.4, R:2.7 ± 0.4 pg/mL; P = 0.006), as was the anti‐inflammatory IL‐6:TNF‐α ratio (E:5.53 ± 0.93, R:3.75 ± 0.45; P = 0.027). Levels of the anti‐inflammatory cytokine IL‐10 increased on day two of the exercise trial (E:2.11 ± 0.23, R:1.66 ± 0.16 pg/mL; P = 0.032). Insulin sensitivity was enhanced on the exercise trial with a reduction in iAUC following the standardized lunch (E:2310 ± 834, R:3122 ± 1443 mU/L × 120 minutes; P < 0.001). Games‐based activity stimulated an anti‐inflammatory response up to 24 hours post‐exercise and improved insulin sensitivity in response to a standardized meal in healthy adolescents. These novel findings suggest that games‐based activity is an ecologically valid mode of exercise to elicit beneficial effects on cardio‐metabolic risk factors in young people.

show abstract

Interrelations among the adipocytokines leptin and adiponectin, oxidative stress and aseptic inflammation markers in pre- and early-pubertal normal-weight and obese boys

Cited by 40 publications

References 53 publications

Chronic stress and body composition disorders: implications for health and disease

Chronic stress and body composition disorders: implications for health and disease

Racial Disparities in Obesity Treatment

Cytokine, glycemic, and insulinemic responses to an acute bout of games‐based activity in adolescents

Contact Info

Product

Resources

About