Interrelation between plasma testosterone and plasma insulin in healthy adult men: the Telecom Study

Simon, Dominique; Preziosi, Paul; Barrett‐Connor, Elizabeth; Roger, M; Saint-Paul, M; Nahoul, K; Papoz, L

doi:10.1007/bf00402551

Cited by 141 publications

(85 citation statements)

References 46 publications

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“…RRs were altered considerably for the two extreme sleep groups when adjusted for testosterone, which is inversely related to waist circumference. In previous studies, low levels of testosterone have been associated with risk factors for diabetes including obesity (21), body fat distribution (increased waist-to-hip ratio) (22), and elevated levels of insulin and glucose (22,23). Low levels of testosterone were previously related to diabetes in this cohort (24) and others (25).…”

Section: Biological Mechanismsmentioning

confidence: 53%

Sleep Duration as a Risk Factor for the Development of Type 2 Diabetes

Yaggi

Araujo²,

McKinlay³

2006

Diabetes Care

664

454

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OBJECTIVE -Short-term partial sleep restriction results in glucose intolerance and insulin resistance. The purpose of this study was to assess the long-term relationship between sleep duration and the incidence of clinical diabetes. RESEARCH DESIGN AND METHODS -A cohort of men from the MassachusettsMale Aging Study without diabetes at baseline (1987)(1988)(1989) were followed until 2004 for the development of diabetes. Average number of hours of sleep per night was grouped into the following categories: Յ5, 6, 7, 8, and Ͼ8 h. Incidence rates and relative risks (RRs) were calculated for the development of diabetes in each sleep duration category. Those reporting 7 h of sleep per night served as the reference group. Multivariate analysis was performed using Poisson regression.RESULTS -Men reporting short sleep duration (Յ5 and 6 h of sleep per night) were twice as likely to develop diabetes, and men reporting long sleep duration (Ͼ8 h of sleep per night) were more than three times as likely to develop diabetes over the period of follow-up. Elevated risks remained essentially unchanged after adjustment for age, hypertension, smoking status, self-rated health status, education, and waist circumference .01] for Յ5 h and 3.12 [1.53-6.37] for Ͼ8 h). RRs were altered considerably for the two extreme sleep groups when adjusted for testosterone (1.51 [0.71-3.19] for Յ5 h and 2.81 [1. 34 -5.90] for Ͼ8 h), suggesting that the effects of sleep on diabetes could be mediated via changes in endogenous testosterone levels.CONCLUSIONS -Short and long sleep durations increase the risk of developing diabetes, independent of confounding factors. Sleep duration may represent a novel risk factor for diabetes. Diabetes Care 29:657-661, 2006D iabetes remains a critical public health challenge. The prevalence of diabetes continues to increase, and it affects an estimated 18 million people in the U.S. (1-3). Patients with diabetes require frequent contact with the health care system for effective management and prevention of complications, and they are at increased risk for premature mortality and hospitalization for conditions such as cardiovascular and kidney disease. Although lifestyle changes such as weight loss and increasing physical activity are the cornerstone of diabetes prevention, efforts are needed to better understand other determinants of the disease and to develop additional prevention strategies. Understanding the link between diabetes and sleep may represent one important part of that effort.Sleep loss is a common condition in modern society, with evidence showing that we are sleeping on average only 6.8 h per night, which is 1.5 h less than we did a century ago (4,5). Nearly one-third of adults report sleeping Ͻ6 h per night, leading some to suggest we live in a sleepdeprived society (6). Factors responsible for this change include increases in environmental light, longer work days/ commuting time, an increase in shift and night work, and the advent of television, radio, and the Internet (7).We are only beginning to reco...

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Section: Biological Mechanismsmentioning

confidence: 53%

Sleep Duration as a Risk Factor for the Development of Type 2 Diabetes

Yaggi

Araujo²,

McKinlay³

2006

Diabetes Care

664

454

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“…34,227,228 There is positive correlation between serum testosterone levels and insulin sensitivity in men across the full spectrum of glucose tolerance 229 and an improvement of insulin sensitivity was noted after replacement. 230 Although Abate et al 231 found no association between low plasma levels of bioavailable testosterone and insulin resistance in eugonadal men; a recent larger study (NHANES [National Health and Nutrition Examination Survey]) showed that low free and bioavailable testosterone levels, even in the normal range, are associated with diabetes, independent of adiposity.…”

Section: 224mentioning

confidence: 99%

The benefits and risks of testosterone replacement therapy: a review

Bassil¹,

Alkaade²,

Morley

2009

TCRM

140

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“…Cross-sectional studies demonstrate an inverse relationship between testosterone and fasting insulin levels in men independent of age, obesity, and body fat distribution (7)(8)(9)(10)(11). A link between testosterone deficiency and diabetes has also been suggested with the demonstration that men with type 2 diabetes have lower testosterone levels than weight-matched nondiabetic control subjects (12,13).…”

mentioning

confidence: 99%

Relationship Between Testosterone Levels, Insulin Sensitivity, and Mitochondrial Function in Men

et al. 2005

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OBJECTIVE -The goal of this study was to examine the relationship between serum testosterone levels and insulin sensitivity and mitochondrial function in men.RESEARCH DESIGN AND METHODS -A total of 60 men (mean age 60.5 Ϯ 1.2 years) had a detailed hormonal and metabolic evaluation. Insulin sensitivity was measured using a hyperinsulinemic-euglycemic clamp. Mitochondrial function was assessed by measuring maximal aerobic capacity (VO 2max ) and expression of oxidative phosphorylation genes in skeletal muscle.RESULTS -A total of 45% of subjects had normal glucose tolerance, 20% had impaired glucose tolerance, and 35% had type 2 diabetes. Testosterone levels were positively correlated with insulin sensitivity (r ϭ 0.4, P Ͻ 0.005). Subjects with hypogonadal testosterone levels (n ϭ 10) had a BMI Ͼ25 kg/m 2 and a threefold higher prevalence of the metabolic syndrome than their eugonadal counterparts (n ϭ 50); this relationship held true after adjusting for age and sex hormone-binding globulin but not BMI. Testosterone levels also correlated with VO 2max (r ϭ 0.43, P Ͻ 0.05) and oxidative phosphorylation gene expression (r ϭ 0.57, P Ͻ 0.0001).CONCLUSIONS -These data indicate that low serum testosterone levels are associated with an adverse metabolic profile and suggest a novel unifying mechanism for the previously independent observations that low testosterone levels and impaired mitochondrial function promote insulin resistance in men.

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Interrelation between plasma testosterone and plasma insulin in healthy adult men: the Telecom Study

Cited by 141 publications

References 46 publications

Sleep Duration as a Risk Factor for the Development of Type 2 Diabetes

Sleep Duration as a Risk Factor for the Development of Type 2 Diabetes

The benefits and risks of testosterone replacement therapy: a review

Relationship Between Testosterone Levels, Insulin Sensitivity, and Mitochondrial Function in Men

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