Interrelation between Human Fertility and Seminal Plasma Lipids, Prostaglandins and Zinc

Hafiez, A. A.; Zaki, K.; Abbas, E. Z.; Halawa, F. A.

doi:10.1080/10256018608623645

Isotopenpraxis Isotopes in Environmental and Health Studies

1986

DOI: 10.1080/10256018608623645

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Interrelation between Human Fertility and Seminal Plasma Lipids, Prostaglandins and Zinc

A. A. Hafiez

K. Zaki

E. Z. Abbas

et al.

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2001

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“…Lipids play an important role in the functional activity of sperm and thus in male infertility [9]. Semen analysis of mammals has shown that processing, capacitation and acrosome reaction are associated with multiple specific modifications of phospholipid composition of sperm plasma membrane [3,[16][17][18].…”

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Phospholipid Composition of Human Sperm and Seminal Plasma in Relation to Sperm Fertility

Gulaya

2001

Archives of Andrology

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The phospholipid and fatty acid composition of sperm was studied in 8 healthy and 16 infertile men. Infertile men randomly formed from the patients with normal semen parameters according to WHO criterion. Therefore, all semen parameters of infertile patients were similar to the same characteristics of the semen of healthy men, except the abnormal forms. The amount of abnormal forms in infertile men was significantly higher than in healthy men. Sperm from infertile men show a drastic loss of phosphatidyl ethanolamine. At the same time, the significant increase of phosphatidyl serine in the sperm and seminal plasma of sterile patients was found. Lysophosphatidyl serine in the sperm of the infertile men was detected. Fatty acid composition of the semen of infertile men was altered. The levels of stearic and n-3 polyunsaturated fatty acids (eicosopentaenoic and docosahexaenoic acids) was dramatically lowered, but the values of some n-6 polyunsaturated fatty acids (linolenic and docosatetraenoic) acids increased. There was significant positive correlation between docosahexaenoic acid and sperm motility (r = .82, p < .001) and negative correlation between linolenic acid and spermatozoa motility (r = -0.58. p < .05). Infertility of men with normal semen quality can originate from the disorder of sperm lipid metabolism. The drastic loss of phosphatidyl ethanolamine and n-3 polyunsaturated fatty acids with simultaneous enhancement of phosphatidyl serine and some n-6 polyunsaturated fatty acids in sperm could be an important cause of male infertility.

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“…Asthenozoospermia is associated with lower concentration of sperm docosahexaenoic acid [27] and higher omega6/omega3 fatty acids ratio [7]. Oligozoospermia and azoospermia are linked to alteration of phospholipid and neutral lipid composition [9,19]. Unfortunately, the sperm lipid composition of infertile men with normozoospermia is poorly understood.…”

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confidence: 99%

Phospholipid Composition of Human Sperm and Seminal Plasma in Relation to Sperm Fertility

Gulaya

2001

Archives of Andrology

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Interrelation between Human Fertility and Seminal Plasma Lipids, Prostaglandins and Zinc

Cited by 1 publication

References 28 publications

Phospholipid Composition of Human Sperm and Seminal Plasma in Relation to Sperm Fertility

Phospholipid Composition of Human Sperm and Seminal Plasma in Relation to Sperm Fertility

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