Interrelation between gut microbiota and bronchial asthma

Abstract

This article is a review of indigenous and foreign literature concerning the influence of the quantitative and qualitative composition of intestinal microbiota, as well as certain metabolites of bacteria-commensals, on the manifestation of bronchial asthma. This topic is particularly relevant nowadays due to the widespread overuse of antibiotic therapy, and additionally, the availability of possible ways to prevent the manifestation of this disease if the influence of the microbiota on the pathogenesis of bronchial asthma is detected. Bronchial asthma is a chronic disease of the respiratory tract with insufficiently studied etiology and pathogenesis. Many authors suggest a significant contribution of intestinal microbiota to the etiology of this pathology. The existence of a gut-lung axis, through which bacterial metabolites influence airway sensibilization, has been proven. Certainly, forming this connection in childhood plays an important role. Of particular interest is the question of the influence of antibiotic therapy on pregnant women and young children at the risk of bronchial asthma, a relationship confirmed in many studies. However, despite the large number of articles, the use of probiotics for the treatment and prevention of this disease is still debatable.