Interrater variation of vascular classifications used in enhanced laryngeal contact endoscopy

Mehlum, Camilla Slot; Døssing, Helle; Davaris, Nikolaos; Giers, Anja; Grøntved, Ågot Møller; Kjærgaard, Thomas; Möller, Sören; Godballe, Christian; Arens, Christoph

doi:10.1007/s00405-020-06000-z

Cited by 7 publications

(7 citation statements)

References 35 publications

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“…Specifically, the accuracy was 93.9%, according to ELS, and 85.1%, according to the NI 2019 classification. The combined use of contact endoscopy (CE) and NBI has already been suggested for visualizing specific vascular changes indicative of glottic neoplasia (33). However, inter-rater reliability and agreement in three classification systems proved to be the best for vascular changes by the ELS and was significantly higher than those by Ni et al and Puxeddu et al (33).…”

Section: Discussionmentioning

confidence: 99%

Leukoplakia: An Invasive Cancer Hidden within the Vocal Folds. A Multivariate Analysis of Risk Factors

et al. 2021

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IntroductionDiscerning the preoperative nature of vocal fold leukoplakia (VFL) with a substantial degree of certainty is fundamental, seeing that the histological diagnosis of VFL includes a wide spectrum of pathology and there is no consensus on an appropriate treatment strategy or frequency of surveillance. The goal of our study was to establish a clear schedule of the diagnostics and decision-making in which the timing and necessity of surgical intervention are crucial to not miss this cancer hidden underneath the white plaque.Material and MethodsWe define a schedule as a combination of procedures (white light and Narrow Band Imaging diagnostic tools), methods of evaluating the results (a combination of multiple image classifications in white light and Narrow Band Imaging), and taking into account patient-related risk factors, precise lesion location, and morphology. A total number of 259 patients with 296 vocal folds affected by leukoplakia were enrolled in the study. All patients were assessed for three classifications, in detail according to Ni 2019 and ELS 2015 for Narrow Band Imaging and according to Chen 2019 for white light. In 41 of the 296 folds (13.9%), the VFL specimens in the final histology revealed invasive cancer. We compared the results from the classifications to the final histology results.ResultsThe results showed that the classifications and evaluations of the involvement of anterior commissure improve the clinical utility of these classifications and showed improved diagnostic performance. The AUC of this model was the highest (0.973) with the highest sensitivity, specificity, PPV, and NPV (90.2%, 89%, 56.9%, and 98.3%, respectively).ConclusionThe schedule that combines white light and Narrow Band Imaging, with a combination of the two classifications, improves the specificity and predictive value, especially of anterior commissure involvement.

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Section: Discussionmentioning

confidence: 99%

Leukoplakia: An Invasive Cancer Hidden within the Vocal Folds. A Multivariate Analysis of Risk Factors

et al. 2021

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“…Several approaches have been proposed to describe and classify these vascular changes. Among the complex classification systems proposed by [ 3 ] and [ 4 ], the European Laryngological Society (ELS) introduced a simplified classification that divides vascular changes into longitudinal and perpendicular classes [ 5 , 6 ]. Longitudinal Vascular Changes (LVC) spread along the length and width of the vocal fold and can be observed in all kinds of benign or malignant lesions.…”

Section: Introductionmentioning

confidence: 99%

Laryngeal Lesion Classification Based on Vascular Patterns in Contact Endoscopy and Narrow Band Imaging: Manual Versus Automatic Approach

Esmaeili

Illanes

Boese

et al. 2020

Sensors

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Longitudinal and perpendicular changes in the vocal fold’s blood vessels are associated with the development of benign and malignant laryngeal lesions. The combination of Contact Endoscopy (CE) and Narrow Band Imaging (NBI) can provide intraoperative real-time visualization of the vascular changes in the laryngeal mucosa. However, the visual evaluation of vascular patterns in CE-NBI images is challenging and highly depends on the clinicians’ experience. The current study aims to evaluate and compare the performance of a manual and an automatic approach for laryngeal lesion’s classification based on vascular patterns in CE-NBI images. In the manual approach, six observers visually evaluated a series of CE+NBI images that belong to a patient and then classified the patient as benign or malignant. For the automatic classification, an algorithm based on characterizing the level of the vessel’s disorder in combination with four supervised classifiers was used to classify CE-NBI images. The results showed that the manual approach’s subjective evaluation could be reduced by using a computer-based approach. Moreover, the automatic approach showed the potential to work as an assistant system in case of disagreements among clinicians and to reduce the manual approach’s misclassification issue.

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“…By providing higher contrasted vascular patterns, NBI can help overcome the ‘umbrella effect’ caused by vocal fold leukoplakia, a white plaque covering the mucosa that can obscure vascular changes 12 , 13 . However, the evaluation of vascular patterns largely depends on the classification system used and is subject to the individual experience of each endoscopist 14 , 15 .…”

Section: Background and Summarymentioning

confidence: 99%

Contact Endoscopy – Narrow Band Imaging (CE-NBI) data set for laryngeal lesion assessment

Esmaeili,

Davaris,

Boese

et al. 2023

Sci Data

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The endoscopic examination of subepithelial vascular patterns within the vocal fold is crucial for clinicians seeking to distinguish between benign lesions and laryngeal cancer. Among innovative techniques, Contact Endoscopy combined with Narrow Band Imaging (CE-NBI) offers real-time visualization of these vascular structures. Despite the advent of CE-NBI, concerns have arisen regarding the subjective interpretation of its images. As a result, several computer-based solutions have been developed to address this issue. This study introduces the CE-NBI data set, the first publicly accessible data set that features enhanced and magnified visualizations of subepithelial blood vessels within the vocal fold. This data set encompasses 11144 images from 210 adult patients with pathological vocal fold conditions, where CE-NBI images are annotated using three distinct label categories. The data set has proven invaluable for numerous clinical assessments geared toward diagnosing laryngeal cancer using Optical Biopsy. Furthermore, given its versatility for various image analysis tasks, we have devised and implemented diverse image classification scenarios using Machine Learning (ML) approaches to address critical clinical challenges in assessing laryngeal lesions.

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Interrater variation of vascular classifications used in enhanced laryngeal contact endoscopy

Abstract: as no identifying information about participants was investigated in the study. The study was approved by the Danish Data Protection Agency, the local hospital management and the legal department at Odense University Hospital (permit number 20/15307).

Cited by 7 publications

References 35 publications

Leukoplakia: An Invasive Cancer Hidden within the Vocal Folds. A Multivariate Analysis of Risk Factors

Leukoplakia: An Invasive Cancer Hidden within the Vocal Folds. A Multivariate Analysis of Risk Factors

Laryngeal Lesion Classification Based on Vascular Patterns in Contact Endoscopy and Narrow Band Imaging: Manual Versus Automatic Approach

Contact Endoscopy – Narrow Band Imaging (CE-NBI) data set for laryngeal lesion assessment

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