Interpreting the transmissibility of measles in two different post periods of supplementary immunization activities in Hubei, China

Chong, Ka Chun; Zhang, Chi; Zee, Benny; Luo, Tongyong; Wang, Lei; Tam, Greta; Jia, Katherine Min; Sun, Riyang; Wang, Maggie Haitian; Guan, Xiaohong

doi:10.1016/j.vaccine.2017.01.010

Cited by 16 publications

(16 citation statements)

References 31 publications

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“…The rise in measles incidence rates among older age groups, especially the 9-23-month-old and 2-6-year-old groups, resulted from the aggregation of susceptible individuals after the province-wide SIAs were introduced, owing to lower vaccination coverage or primary vaccine failures. Low vaccination coverage among newly born cohorts after the 2010 SIAs was a key contributor to the national resurgence [32,35]. A recent survey conducted in Guangdong revealed that MV1 coverage was 71.8% among migrant children aged 12-59 months, and that only 37.2% had MV1 administered in the appropriate time [36].…”

Section: Discussionmentioning

confidence: 99%

Epidemiological changes in measles infections in southern China between 2009 and 2016: a retrospective database analysis

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Epidemiological changes in measles infections in southern China between 2009 and 2016: a retrospective database analysis

et al. 2020

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“…A similar situation has also been observed in other provinces in China; at times, more cases might be reported in the younger age groups (e.g., 7-15 years old) . This phenomenon could be explained by the multiple studies showing that young adults in China have significantly lower measles seropositivity (Fu et al, 2010;Chong et al, 2017;Boulton et al, 2016). Although the exact cause of the low seropositivity among young adults remains unknown, studies have suggested that a lack of immunization is probably the reason (Fu et al, 2010;Chong et al, 2017;Boulton et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…This phenomenon could be explained by the multiple studies showing that young adults in China have significantly lower measles seropositivity (Fu et al, 2010;Chong et al, 2017;Boulton et al, 2016). Although the exact cause of the low seropositivity among young adults remains unknown, studies have suggested that a lack of immunization is probably the reason (Fu et al, 2010;Chong et al, 2017;Boulton et al, 2016). This could also possibly explain the large proportion of 16-30-year-old individuals among the infected migrants, as most of them were not covered by the immunization program in the past when compared to the urban population, especially those born after 1985 when two-dose MV had just been introduced but with limited coverage.…”

Section: Discussionmentioning

confidence: 99%

Were infections in migrants associated with the resurgence of measles epidemic during 2013–2014 in southern China? A retrospective data analysis

Chong

Chan

et al. 2020

International Journal of Infectious Diseases

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substantial increases in the proportion of infection were detected among children aged <8 months and the unvaccinated population (p < 0.01). Conclusions: The study findings suggest that infections in migrants might not have been the major cause of the epidemic resurgence of measles. Instead, the resurgence was likely due to infections among children aged <8 months and the unvaccinated. Thus, officials are advised to give higher priority to appropriate populations when formulating control measures, and to strengthen routine surveillance of vaccination coverage among them.

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“…Apparently, the age specificity in measles transmissions could be affected by vaccination policies. Chong et al [18] showed that even though substantial decreases in the numbers of cases were observed after mass vaccination campaign, measles could still persist in a population given a high value of R.…”

Section: Introductionmentioning

confidence: 99%

Monitoring the age-specificity of measles transmissions during 2009-2016 in Southern China

Chong

Lau

et al. 2018

PLoS ONE

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BackgroundDespite several immunization efforts, China saw a resurgence of measles in 2012. Monitoring of transmissions of individuals from different age groups could offer information that would be valuable for planning adequate disease control strategies. We compared the age-specific effective reproductive numbers (R) of measles during 2009–2016 in Guangdong, China.MethodsWe estimated the age-specific R values for 7 age groups: 0–8 months, 9–18 months, 19 months to 6 years, 7–15 years, 16–25 years, 26–45 years, and ≥46 years adapting the contact matrix of China. The daily numbers of laboratory and clinically confirmed cases reported to the Center for Disease Control and Prevention of Guangdong were used.ResultsThe peak R values of the entire population were above unity from 2012 to 2016, indicating the persistence of measles in the population. In general, children aged 0–6 years and adults aged 26–45 years had larger values of R when comparing with other age groups after 2012. While the peaks of R values for children aged 0–6 years dropped steadily after 2013, the peaks of R values for adults aged 26–45 years kept at a high range every year.ConclusionsAlthough the provincial supplementary immunization activities (SIAs) conducted in 2009 and 2010 were able to reduce the transmissions from 2009 to 2011, larger values of R for children aged 0–6 years were observed after 2012, indicating that the benefits of the SIAs were short-lived. In addition, the transmissions from adults aged between 26 and 45 years increased over time. Disease control strategies should target children and adult groups that carry high potential for measles transmission.

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Interpreting the transmissibility of measles in two different post periods of supplementary immunization activities in Hubei, China

Cited by 16 publications

References 31 publications

Epidemiological changes in measles infections in southern China between 2009 and 2016: a retrospective database analysis

Epidemiological changes in measles infections in southern China between 2009 and 2016: a retrospective database analysis

Were infections in migrants associated with the resurgence of measles epidemic during 2013–2014 in southern China? A retrospective data analysis

Monitoring the age-specificity of measles transmissions during 2009-2016 in Southern China

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