Interpreting the clinical importance of the relationship between subjective fatigue and cognitive impairment in multiple sclerosis (MS): How BICAMS performance is affected by MS-related fatigue

Bellew, David; Davenport, Laura; Monaghan, Ruth; Cogley, Clodagh; Gaughan, Maria; Yap, Siew Mei; Tubridy, Niall; Bramham, Jessica; McGuigan, Christopher; O’Keeffe, Fiadhnait

doi:10.1016/j.msard.2022.104161

Multiple Sclerosis and Related Disorders

2022

DOI: 10.1016/j.msard.2022.104161

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Interpreting the clinical importance of the relationship between subjective fatigue and cognitive impairment in multiple sclerosis (MS): How BICAMS performance is affected by MS-related fatigue

David Bellew

Laura Davenport²,

Ruth Monaghan³

et al.

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Cited by 2 publications

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Patterns of attention deficit in relapsing and progressive phenotypes of multiple sclerosis

Tabibian,

Azimzadeh,

Shaygannejad

et al. 2023

Sci Rep

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Behavioral aspects and underlying pathology of attention deficit in multiple sclerosis (MS) remain unknown. This study aimed to clarify impairment of attention and its relationship with MS-related fatigue. Thirty-four relapse-remitting MS (RRMS), 35 secondary-progressive MS (SPMS) and 45 healthy controls (HC) were included. Results of psychophysics tasks (attention network test (ANT) and Posner spatial cueing test) and fatigue assessments (visual analogue scale and modified fatigue impact scale (MFIS)) were compared between groups. In ANT, attentional network effects were not different between MS phenotypes and HC. In Posner task, RRMS or SPMS patients did not benefit from valid cues unlike HC. RRMS and SPMS patients had less gain in exogenous trials with 62.5 ms cue-target interval time (CTIT) and endogenous trials with 250 ms CTIT, respectively. Total MFIS was the predictor of gain in 250 ms endogenous blocks and cognitive MFIS predicted orienting attentional effect. Executive attentional effect in RRMS patients with shorter disease duration and orienting attentional effect in longer diagnosed SPMS were correlated with MFIS scores. The pattern of attention deficit in MS differs between phenotypes. Exogenous attention is impaired in RRMS patients while SPMS patients have deficit in endogenous attention. Fatigue trait predicts impairment of endogenous and orienting attention in MS.

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Patterns of attention deficit in relapsing and progressive phenotypes of multiple sclerosis

Tabibian,

Azimzadeh,

Shaygannejad

et al. 2023

Sci Rep

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The relationship between cognitive function and functional capacity, and cognitive reserve and reaction time in patients with multiple sclerosis

Candiri,

Ramazanoglu,

Talu

et al. 2024

Arq Neuropsiquiatr

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Background Cognitive dysfunction is frequently seen in multiple sclerosis (MS). However, there are conflicting findings regarding the factors it is associated with. Objective To investigate the relationship between aerobic capacity, strength, disability, depression, fatigue, and cognitive reserve and function. Methods The mobile applications Trail Making Test (TMT A-B), Digit Span Test (DST), Visuospatial Memory Test (VSMT), and Tap Fast were used in the cognitive function evaluation. Functional performance was assessed with the 6-minute walk test (6MWT), 5-Time Sit-to-Sand (5STS) test, and grip strength. Cognitive Reserve Index (CRI), Beck Depression Inventory, Fatigue Severity Scale (FSS), and Nottingham Health Profile were also used. Results A significant difference was found between the MS and control groups only in the 6MWT, STS-5, grip strength, TMT, VSMT, and Tap Fast. Good correlation was found between the TMT-A and 6MWT and physical mobility. A fair correlation was shown between grip strength, energy, and pain status. A good correlation was found between TMT-B and 6MWT, and a fair relationship with disability, cognitive reserve, and pain. Good correlation was observed between the DST and 6MWT, left grip strength, pain, and energy status; fair correlations were found between right grip strength, cognitive reserve, and physical mobility. Good correlation was found between the VSMT and energy. A fair relationship between disability, cognitive reserve, and pain was demonstrated. Good correlation was observed between the Tap Fast score and disability, 5STS, FSS, energy, and physical mobility. A fair relationship was found between pain and social isolation. Conclusion It has been shown that cognitive performance in MS is related to disability, functional performance, cognitive reserve, fatigue, and general health. Trial registration NCT06084182.

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Interpreting the clinical importance of the relationship between subjective fatigue and cognitive impairment in multiple sclerosis (MS): How BICAMS performance is affected by MS-related fatigue

Cited by 2 publications

References 63 publications

Patterns of attention deficit in relapsing and progressive phenotypes of multiple sclerosis

Patterns of attention deficit in relapsing and progressive phenotypes of multiple sclerosis

The relationship between cognitive function and functional capacity, and cognitive reserve and reaction time in patients with multiple sclerosis

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