Interpreting studies that compare high- and low-selected lines on new characters

Henderson, Norman D.

doi:10.1007/bf01066250

Cited by 82 publications

(69 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…29). However, it should be noted that some of the phenotypic differences observed between the HL and NHL might be attributed to a genetic drift phenomenon during the selection step (30), rather than being related to the trait of selection. Further segregating cross-breeding studies are necessary to determine whether phenotypic differences between the two lines have a genetic relationship to the trait of selection.…”

Section: Discussionmentioning

confidence: 99%

Behavioral, neurochemical, and electrophysiological characterization of a genetic mouse model of depression

Yacoubi

Bouali

Popa

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

239

173

View full text Add to dashboard Cite

Depression is a multifactorial illness and genetic factors play a role in its etiology. The understanding of its physiopathology relies on the availability of experimental models potentially mimicking the disease. Here we describe a model built up by selective breeding of mice with strikingly different responses in the tail suspension test, a stress paradigm aimed at screening potential antidepressants. Indeed, ''helpless'' mice are essentially immobile in the tail suspension test, as well as the Porsolt forced-swim test, and they show reduced consumption of a palatable 2% sucrose solution. In addition, helpless mice exhibit sleep-wakefulness alterations resembling those classically observed in depressed patients, notably a lighter and more fragmented sleep, with an increased pressure of rapid eye movement sleep. Compared with ''nonhelpless'' mice, they display higher basal seric corticosterone levels and lower serotonin metabolism index in the hippocampus. Remarkably, serotonin 1A autoreceptor stimulation induces larger hypothermia and inhibition of serotoninergic neuronal firing in the nucleus raphe dorsalis in helpless than in nonhelpless mice. Thus, helpless mice exhibit a decrease in serotoninergic tone, which evokes that associated with endogenous depression in humans. Finally, both the behavioral impairments and the serotoninergic dysfunction can be improved by chronic treatment with the antidepressant fluoxetine. The helpless line of mice may provide an opportunity to approach genes influencing susceptibility to depression and to investigate neurophysiological and neurochemical substrates underlying antidepressant effects.T he prevalence of depression worldwide is such that this disorder represents a major health problem. It is estimated, for example, that Ϸ10% of men and 20% of women in Western Europe will suffer from a major depressive episode at some time in their life. The monoamine hypothesis of depression suggests that one of the biological bases of affective disorders is a deficiency in the neurotransmitter serotonin (5-HT). During the past 40 yr, this hypothesis has been refined, as more experimental and clinical evidence has emerged. The selective 5-HT reuptake inhibitors, in particular, allowed important progress in our understanding of the role of 5-HT in depression. To some extent, the mechanism of action of 5-HT reuptake inhibitors, which are the most widely prescribed antidepressant drugs today, can be anticipated from our knowledge of the anatomy and chemistry of the central serotoninergic system. However, it must be accepted that extensive investigations have so far failed to find convincing evidence of a primary dysfunction of the serotoninergic system in patients with depression. Disturbances of sleep are typical for most depressed patients and belong to the core symptoms of the disorder. Polysomnographic sleep research has demonstrated that, besides disturbances of sleep continuity, depression is associated with a reduction of slow-wave sleep and a shortening of rapid eye movement (REM...

show abstract

Section: Discussionmentioning

confidence: 99%

Behavioral, neurochemical, and electrophysiological characterization of a genetic mouse model of depression

Yacoubi

Bouali

Popa

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

239

173

View full text Add to dashboard Cite

show abstract

“…Because the lines were separately propagated for 29 generations, mice in a given generation do not represent independent data points (i.e., mice within a line are genetically more similar to one another than mice between lines). Therefore, the individual subjects must be nested within the populations to which they belong (Henderson, 1989(Henderson, , 1997. To satisfy this requirement, line was always entered as a random effect (for theoretical justification of this approach see Pinheiro & Bates, 2000), nested within the fixed effect, line-type (S vs. C) using the Proc Mixed command in SAS (Littell, Milliken, Stroup, & Wolfinger, 1996).…”

Section: Discussionmentioning

confidence: 99%

Patterns of Brain Activity Associated With Variation in Voluntary Wheel-Running Behavior.

Rhodes

Garland

Gammie

2003

Behavioral Neuroscience

195

200

View full text Add to dashboard Cite

Rodents spontaneously run on wheels, but what underlies variation within and between species is unknown. This study used Fos immunoreactivity to compare brain activity in mice selectively bred for high wheel running (S) versus control (C) mice. Mice ran for 6 days, but on Day 7, half the mice were prevented from running. A strong positive correlation was found between running distance and Fos in the dentate gyrus of C runners that was lost in S runners. In mice prevented from running, Fos was higher in S than in C in the lateral hypothalamus, medial frontal cortex, and striatum. Results implicate specific brain regions in motivation to run and others in control of the intensity of the locomotor behavior itself.Voluntary wheel running is one of the most widely studied behaviors in laboratory rodents, yet the underlying cause of variation in this behavior is not known (Sherwin, 1998). Recently, it has been proposed that wheel running is naturally rewarding and addictive

show abstract

“…For this purpose, each of the four replicates can be treated as an independent evolutionary event estimating the strength of the correlated response. The variance among replicates measures the deviation from the parametric value of (Henderson, 1989).…”

Section: Methodsmentioning

confidence: 99%

Test of indirect models of selection in the Trinidad guppy

Breden

Hornaday

1994

Heredity

View full text Add to dashboard Cite

Indirect models for the evolution of female preference assume that preference does not evolve as a result of direct selection but rather through genetic correlations with positively selected male traits. An essential assumption of Fisherian models and many recent good genes models is that assortative mating causes a genetic correlation to develop between alleles conferring high preference and alleles conferring high levels of the male attractive phenotype. In a direct test of indirect selection models, mass selection on attractive male coloration did not result in a correlated response in female preference in replicate treatments from a high predation population of the Trinidad guppy. The response was consistently low and a power analysis showed that genetic drift was not likely to explain the low response across all replicates. These results contrast with studies demonstrating such a correlation in another population of guppies and in three-spined sticklebacks.

show abstract

Interpreting studies that compare high- and low-selected lines on new characters

Cited by 82 publications

References 10 publications

Behavioral, neurochemical, and electrophysiological characterization of a genetic mouse model of depression

Behavioral, neurochemical, and electrophysiological characterization of a genetic mouse model of depression

Patterns of Brain Activity Associated With Variation in Voluntary Wheel-Running Behavior.

Test of indirect models of selection in the Trinidad guppy

Contact Info

Product

Resources

About