Interpreting murine tolerance experiments

Trambley, Joel; Pearson, Thomas C.; Larsen, Christian

doi:10.1097/00075200-200006000-00011

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…The strain sensitivity of murine transplant studies represents a signi¢cant problem in interpreting the generalizability of rodent protocols (Trambley et al 2000). Moreover, the literature is replete with immunological therapies successful in the rodent but not in higher species.…”

Section: Cd154 In the Context Of Transplantationmentioning

confidence: 99%

“…Unfortunately, some strains of rodents, for example C57Bl/6 mice, have been shown to be relatively resistant to the potent e¡ect of anti-CD154-based therapies (Larsen et al 1996a,b;Trambley et al 1999Trambley et al , 2000. In response to this, Larsen and colleagues demonstrated that treatment with CTLA-4-Ig was synergistic with anti-CD154 therapy (Larsen et al 1996a,b).…”

Section: Cd154 In the Context Of Transplantationmentioning

confidence: 99%

See 1 more Smart Citation

The role of CD154 in organ transplant rejection and acceptance

Kirk

Blair

Tadaki

et al. 2001

Phil. Trans. R. Soc. Lond. B

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CD154 plays a critical role in determining the outcome of a transplanted organ. This simple statement is amply supported by experimental evidence demonstrating that anti-CD154 antibodies are potent inhibitors of allograft rejection in many rigorous transplant models. Unfortunately, despite intensive investigation over the past ten years, the precise mechanisms by which antibodies against CD154 exert their anti-rejection e¡ects have remained less obvious. Though originally classi¢ed with reference to B-cell function, CD154^CD40 interactions have also been shown to be important in T cell^antigen-presenting cell interactions. Accordingly, CD154 has been classi¢ed as a T-cell co-stimulatory molecule. However, mounting data suggest that treatment with anti-CD154 antibodies does not simply block costimulatory signals, but rather that the antibodies appear to induce signalling in receptor-bearing T cells. Other data suggest that anti-CD154 e¡ects may be mediated by endothelial cells and possibly even platelets. In fact, the current literature suggests that CD154 can either stimulate or attenuate an immune response, depending upon the model system under study. CD154 has secured a fundamental place in transplant biology and general immunology that will no doubt be the source of considerable investigation and therapeutic manipulation in the coming decade.

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Section: Cd154 In the Context Of Transplantationmentioning

confidence: 99%

Section: Cd154 In the Context Of Transplantationmentioning

confidence: 99%

The role of CD154 in organ transplant rejection and acceptance

Kirk

Blair

Tadaki

et al. 2001

Phil. Trans. R. Soc. Lond. B

View full text Add to dashboard Cite

show abstract

“…Investigators should design trials based on animal studies while cognizant of the differences between the animal model and humans (24,25). There are examples of drugs that appeared toxic preclinically only to be found safe and effective in humans (26).…”

Section: Preclinical Datamentioning

confidence: 99%