Interpreting Cardiac Arrhythmias

Synthesis and antimycobacterial activity of new quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives

“…Quinoxaline 1,4-di-N-oxide derivatives even improve the biological results shown by their reduced analogues and are endowed with antiviral, anticancer, antibacterial and antiprotozoal activities. [5][6][7][8][9] There are many publications regarding 1,4-di-N-oxide derivatives, and more specifically alkyl and arylcarboxamide derivatives, in which their antibacterial and antimicrobial activities [10][11][12][13][14] have been reported or their capability to act as antitumoral agents [15,16] has been clearly demonstrated, thereby reflecting the growing interest in these structures over the past forty years.…”

“…Moreover, ketone, carboxylate and carboxamide quinoxaline-1,4-dioxydes derivatives were actually patented in the 70's for their antibacterial activity. [12][13][14][15] These studies have facilitated a wide structure-activity relationship (SAR) analysis which lead us to design a group of thirty-six 3-methylquinoxaline-2-carboxamide 1,4-di-N-oxide derivatives that were prepared and tested against M.Tbc and to justify the design of the compounds presented in this paper. [22] Continuing with the antituberculosis project and in an attempt to establish the structural requirements necessary for the development of anti-tuberculosis drugs, nine series of quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives were proposed ( Figure 2).…”

Synthesis and antimycobacterial activity of new quinoxaline-2-carboxamide 1,4-di-N-Oxide derivatives

“…anticancer, antibacterial and antiprotozoal activities. [5][6][7][8][9] There are many publications regarding 1,4-di-N-oxide derivatives, and more specifically alkyl and arylcarboxamide derivatives, in which their antibacterial and antimicrobial activities [10][11][12][13][14] have been reported or their capability to act as antitumoral agents [15,16] has been clearly demonstrated, thereby reflecting the growing interest in these structures over the past forty years.…”