2007
DOI: 10.1016/j.paed.2007.06.010
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Interpretation of thyroid function in children

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Cited by 7 publications
(5 citation statements)
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“…Furthermore, although we did not observe an inverse association with free T 4 , which would also be expected in the case of hypothyroidism, our suggestive finding of increased free T 3 may be physiologically consistent. In the hypothyroid state, the thyroid may attempt to compensate and convert more thyroid hormone to the most biologically active form, T 3 (Bursell and Warner, 2007; Jameson and De Groot, 2010). Furthermore, although we found that PBDEs were associated with TSH, and potentially total T 4 and free T 3 , it is possible that these associations were not independent due to the thyroid’s negative feedback loop which results in functional relationships between hormones.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, although we did not observe an inverse association with free T 4 , which would also be expected in the case of hypothyroidism, our suggestive finding of increased free T 3 may be physiologically consistent. In the hypothyroid state, the thyroid may attempt to compensate and convert more thyroid hormone to the most biologically active form, T 3 (Bursell and Warner, 2007; Jameson and De Groot, 2010). Furthermore, although we found that PBDEs were associated with TSH, and potentially total T 4 and free T 3 , it is possible that these associations were not independent due to the thyroid’s negative feedback loop which results in functional relationships between hormones.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, although we did not observe an inverse association with free T 4 , which would also be expected in the case of hypothyroidism, our suggestive finding of increased free T 3 may be physiologically consistent. In the hypothyroid state, the thyroid may attempt to compensate and convert more thyroid hormone to the most biologically active form, T 3 (Bursell and Warner, 2007;Jameson and De Groot, 2010). Furthermore, although we found that PBDEs were associated with TSH, and potentially total T 4 and free T 3 , it is possible that these associations were not independent due to the thyroid's negative feedback loop which results in functional relationships between hormones.…”
Section: Discussionmentioning
confidence: 99%
“…However, TSH is regarded as a sensitive marker of thyroid disruption in humans since incremental changes in free T4 hormone concentrations will lead to logarithmic changes in TSH (Bursell et al, 2007). TSH has also been extensively evaluated as a marker of thyroid disruption in newborns due to its frequent use in screening programs.…”
Section: Discussionmentioning
confidence: 99%