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AbstractPressure-depth plots have been used for over thirty years to evaluate fluid density, fluid contacts, and pressure compartmentalization in formation tester pressure surveys. However in the Niger Delta region and other offshore deepwater environments, many reservoirs are multilayered and highly variable in terms of connectivity, permeability and fluid properties. Such complexity and reservoir heterogeneity means conventional pressure-depth plot and pressure gradient analysis of wireline pressure data is not easy, and identification of in-situ fluid type can be difficult. There is also mounting evidence for the presence of compositional gradients in the hydrocarbon columns of some reservoirs -this raises questions about the conventional approach to pressure gradient analysis and uncertainties in inferring fluid properties and contacts from pressure gradients.In this contribution using several field examples, we discuss and review formation pressure measurement techniques and data quality, and compare conventional and advanced methods of pressure gradient analysis and fluid contact determination. The interpretation techniques compared include traditional pressure-depth graphical methods, the excess-pressure method and statistical tests. Depth dependent fluid property variation from fluid gradients, PVT properties and EOS-models are compared and discussed. Guidelines are presented on how to interpret wireline pressure measurements in multilayered siliclastic reservoirs, perform connectivity and compositional gradient assessment. We describe how to improve on these interpretations by performing more advanced formation testing procedures; some of which are based upon new and emerging technology.