Interpretation of Experimental Results for Vancomycin Adsorption on Polymeric Resins in a Fixed Bed Column by Mathematical Modeling with Independently Estimated Parameters

Abstract

A mathematical model of the continuous fixed-bed column adsorption process for isolation of the glycopeptide antibiotic vancomycin, which is an active ingredient in pharmaceutical drugs, from a fermentation broth filtrate on two different polymeric adsorbent resins (Amberlite XAD16N and 1600N) was developed and validated by laboratory-scale experiments. The model was utilized for the prediction of breakthrough curves and, consequently, dynamic adsorption capacities by the application of independently determined adsorption equilibrium and intraparticle kinetic data obtained from batch experiments and hydrodynamic parameters in order to analyze the column performance. The application of structural adsorption/desorption kinetics, taking into account the resin particle size distribution, improved agreement between the calculated and measured data much more than by varying the effect of external mass transfer. A parametric sensitivity analysis of the model was also performed. The study showed that the use of XAD1600N is advantageous in terms of process economics, as the dynamic adsorption capacity is ∼2.5−3.0 times higher, compared to that for XAD16N.

Fluid‐Solid Adsorption in Batch and Continuous Processing: A Review and Insights into Modeling

“…The used model couples the intraparticle mass balance equation given in Eq. (66) with the bulk mass transfer equation in Eq. (75).…”

Adsorption Kinetics of Malachite Green and Methylene Blue from Aqueous Solutions Using Surfactant-modified Organoclays

“…25,26,29 In this work, the Langmuir and Freundlich isotherm models were used to showing the relationship between the amount of adsorbed MG and MB dyes and their concentration in solution at constant pH at room temperature. Langmuir isotherm model suggests that the adsorption of adsorbate molecules by the adsorbent materials takes place on a homogenous surface by monolayer without any interaction with adjacent adsorbed molecules.…”

“…Liquid and gaseous substances can be adsorbed in suitable adsorbent and is widely used in isolation and purification processes in the chemical industries including biotechnology and environmental technology. [24][25][26] Adsorption is very reasonably superior technique because of simplicity of design availability, ability to treat dyes more concentrated from other techniques. 27,28 Being a dynamic process, the rate of adsorption in adsorption equilibrium is controlled by mass transfer processes.…”

Preparation of metal ions impregnated polystyrene resins for adsorption of antibiotics contaminants in aquatic environment

“…Polymer resins have demonstrated their potentials in the application in water purification, organic pollutants or heave metal removal, drug separation, and controlled drug delivery . Recent studies have investigated some commercial hypercrosslinked resins, aminated polystyrene resins, macro/microporous resins and ionic exchange resins for adsorptive removal of antibiotics, such as sulfonamides, tetracyclines, norfloxacin, nalidixic acid, trimethoprim, chloramphenical, and vancomycin . Modified polymer resins have also been engineered to remove pollutants from aqueous environment.…”