A sensitive noninvasive test for peripheral arterial disease (PAD) is the ankle-brachial (ABI) index, which is a ratio of the systolic blood pressure in the ankle to that in the arm. An ABI of less than 0.90 is 97% sensitive for aorto-iliac disease and 89% sensitive for femoro-popliteal disease. 1 The specificity of an ABI value less than 0.90 is 99%. 2 Aside from an objective assessment of lower limb arterial occlusion, ascertainment of leg symptoms is important to identify patient debilitation.Although intermittent claudication is the most classically recognized symptom of PAD in a clinical setting, patients with PAD are often asymptomatic or have symptoms other than intermittent claudication. 3 Daily function is often compromised in PAD including those patients with asymptomatic disease. 4 Prior studies have assessed the association of the ABI and leg function as well as symptom subtype and functional impairment. 3,5,6 The purpose of this study was to assess functional impairment relative to PAD symptom subtype in a racially diverse population, including Spanish-speaking patients, who were receiving primary health care in Houston, Texas. African Americans and 18 Latinos). The mean age of the cohort was 63.8 years (standard deviation (SD) 7.3). Walking distance, speed and stair climbing scores were lower (p Ͻ 0.0001) for patients with PAD and leg pain on exertion or at rest when compared with patients with PAD without leg symptoms or with symptoms of intermittent claudication. For patients with PAD and leg pain on exertion and at rest, the walking distance score was 27.1 Ϯ SD 37.7 compared with 41.0 Ϯ 38.4 for those with asymptomatic disease who were inactive, and with 38.5 Ϯ 42.7 for those with intermittent claudication (p ϭ 0.02).In an ethnically diverse primary care clinic population, patients with PAD and leg pain on exertion and at rest had greater compromise in their walking ability when compared with patients with intermittent claudication. The reasons for the significant impairment in walking among patients with PAD and these atypical leg symptoms may stem from coexisting illnesses or other as yet undefined factors. Future research should focus on methods to improve daily walking in patients with PAD and atypical leg symptoms.