Abstract:The definitions of mean residence time of drug molecules in the body (MRT) from the literature are reviewed. A formal definition of MRT, based on excretion of drug molecules and amount of drug, a parameter which is independent of constancy of both clearance and volume of distribution, is introduced and compared to other existing definitions of MRTs, that is, MRT for the two-compartment model, MRT for the stochastic model, and MRT based on amount in the body. The inherent assumptions of the methods for determin… Show more
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