Interpretación clínica de la determinación de troponina T de elevada sensibilidad

Arbé, Aitor Alquezar; Bel, Miguel Santaló; Sionís, Alessandro

doi:10.1016/j.medcli.2014.11.004

Cited by 7 publications

(5 citation statements)

References 48 publications

(25 reference statements)

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“…Cardiac troponin T and I (cTnT and cTnI) are accepted indicators of myocyte necrosis and are considered sensitive markers of acute myocardial injury (MI) and infarction (AMI) (75). Serum cTnT and cTnI are elevated after irreversible heart muscle damage and levels peak during the subsequent days (1,60). The N-terminal fragment of the prohormone brain natriuretic peptide (NT-proBNP) is a marker accepted to reflect myocardial stretch (74), which is currently used to detect heart failure and asymptomatic left ventricular dysfunction (14,53) with the magnitude and duration of release dependent on the severity of stretch and stress (3).…”

Section: Introductionmentioning

confidence: 99%

“…These assays can detect the 99 th percentile with a CV < 10% and measure cTn concentrations in at least a 50% of a healthy population at rest (59). Although the higher sensitivity of these assays enables better rates of true positive detection (40), a decline in specificity has been reported such that cTn appearance might be related to etiologies other than AMI (1,16,40). This can include physical exercise as a known non-pathological cause of cTn increase (1).…”

Section: Introductionmentioning

confidence: 99%

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Cardiac Biomarker Release After Exercise in Healthy Children and Adolescents: A Systematic Review and Meta-Analysis

Cirer-Sastre

Legaz-Arrese

Corbi

et al. 2019

Pediatric Exercise Science

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Purpose:The authors evaluated the impact of acute exercise and 24-hour recovery on serum concentration of cardiac troponins T and I (cTnT and cTnI) and N-terminal fragment of the prohormone brain natriuretic peptide (NT-proBNP) in healthy children and adolescents. The authors also determined the proportion of participants exceeding the upper reference limits and acute myocardial infarction cutoff for each assay.Method:Web of Science, SPORTDiscus, MEDLINE, ScienceDirect, and Scopus databases were systematically searched up to November 2017. Studies were screened and quality-assessed; the data was systematically extracted and analyzed.Results:From 751 studies initially identified, 14 met the inclusion criteria for data extraction. All 3 biomarkers were increased significantly after exercise. A decrease from postexercise to 24 hours was noted in cTnT and cTnI, although this decrease was only statistically significant for cTnT. The upper reference limit was exceeded by 76% of participants for cTnT, a 51% for cTnI, and a 13% for NT-proBNP. Furthermore, the cutoff value for acute myocardial infarction was exceeded by 39% for cTnT and a 11% for cTnI. Postexercise peak values of cTnT were associated with duration and intensity (Q(3) = 28.3,P < .001) while NT-proBNP peak values were associated with duration (Q(2) = 11.9,P = .003).Conclusion:Exercise results in the appearance of elevated levels of cTnT, cTnI, and NT-proBNP in children and adolescents. Postexercise elevations of cTnT and NT-proBNP are associated with exercise duration and intensity.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cardiac Biomarker Release After Exercise in Healthy Children and Adolescents: A Systematic Review and Meta-Analysis

Cirer-Sastre

Legaz-Arrese

Corbi

et al. 2019

Pediatric Exercise Science

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“…They can also identify cTn levels in at least 50% of healthy individuals when they are at rest. However, this higher sensitivity can sometimes lead to falsepositive results, meaning that the tests may indicate a problem, such as an acute myocardial infarction (AMI), when the elevated level was caused by something else, such as physical exercise (16)(17)(18). The fourth definition, or clinical criterion, for myocardial infarction (MI) "denotes the presence of acute myocardial injury detected by abnormal cardiac biomarkers in the setting of evidence of acute myocardial ischaemia" (19).…”

Section: Introductionmentioning

confidence: 99%

Global research trends on cardiac troponin and physical activity among pediatric populations: a bibliometric analysis and science mapping study

Hernández-González,

Conesa-Milian,

Jové-Deltell

et al. 2024

Front. Pediatr.

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BackgroundCardiac troponin (cTn) is a reliable marker for evaluating myocardial damage. cTn is a very specific protein involved in myocardial injury, and it is a key factor in the diagnosis of coronary syndromes. Bibliometric analysis was applied in the present work, with the main goal of evaluating global research on the topic of cardiac troponin in pediatric populations.MethodsPublications about cardiac troponin and physical activity in pediatric populations were retrieved from the Social Sciences Citation Index (SSCI) and the Science Citation Index Expanded (SCIE) of the Web of Science Core Collection, and they were then analyzed. The study was able to identify the key bibliometric indicators, such as publications, keywords, authors, countries, institutions, and journals. For the analysis, VOSviewer, R-based Bibliometrix (4.2.2), and MapChart were used.ResultsInitially, 98 documents were identified; however, once inclusion and exclusion criteria were applied, the number of documents decreased to 88. The search yielded 79 original research articles and 9 reviews, almost all of which were published in the past 2 decades. The total number of citations (Nc) of the retrieved publications was 1,468, and the average number of citations per article (Na) was 16.68. In general, 508 authors were found to have participated in research about troponin; they were associated with 256 institutions, and their work was published in 65 different journals from around the world. The authors hailed from 30 countries and/or regions. The year 2022 was the most productive year for the publication of the selected documents. The bibliometric analysis provided information regarding levels of cooperation among authors and institutions. In fact, China, the United States, and England were the most productive nations, and the journal with the greatest number of publications on the topic was Pediatric Cardiology.SummaryThe number of publications and the trend line show that research on this topic has not yet reached a stage of maturity. There are referent investigators, countries, and institutions that have laid the foundations for subsequent studies on the analyzed topic.

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“…In addition, the T and I isoforms of cTn (cTnT and cTnI) are highly specific proteins related to myocardial cell damage, and they have become key factors for the diagnosis of acute coronary syndromes and necrosis [ 3 ]. In this regard, serums cTnT and cTnI are elevated after irreversible heart muscle damage and peak during the subsequent days [ 4 , 5 ]. However, it has been shown that cTnI might have a slightly higher sensitivity and earlier release in cardiac injuries compared to cTnT.…”

Section: Introductionmentioning

confidence: 99%

“…High-sensitivity assays have replaced the standard ones and are able to measure the lowest limits of detection in 99% of the population with a coefficient of variation <10% and detect cTn concentrations in at least 50% of a healthy population at rest [ 7 ]. However, this higher sensitivity also allows for some false positives related to etiologies other than acute myocardial infarction (AMI), such as physical exercise [ 4 , 8 , 9 ]. The fourth definition in the clinical criteria for myocardial infarction (MI) denotes “the presence of acute myocardial injury detected by abnormal cardiac biomarkers in the setting of evidence of acute myocardial ischemia” [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Cardiac Troponin Release after Exercise in Healthy Young Athletes: A Systematic Review

Conesa-Milian,

Cirer-Sastre,

Hernández-González

et al. 2023

Healthcare

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Cardiac troponin (cTn) is a recognized marker used to assess damage to the heart muscle. Actual research has indicated that the levels of cTn increase after doing exercise in individuals who are in good health, and this is believed to be a result of a normal cellular process rather than a pathological one. The main goal of this study was to investigate the evidence of a postexercise release of cTn in child and adolescent athletes (6–17.9 years old) of different ages, sex, and sports disciplines. The Web of Science, MEDLINE, and Scopus databases were used to conduct the research up to March 2023. Three hundred and twenty-eight records were identified from the databases, however, only twenty-three studies were included in the review after being screened and quality-assessed by two independent authors. The gender, age of the participants, maturational status, and training level of the participants, the timing of sample collection, the exercise modality, and the number of participants with values above the cut-off reference were the data analyzed. Males, older young people, and individual sports seemed to have higher levels of serum cTn after practice exercise. Different methodologies, analyzers, and cut-off reference values make it difficult to compare the data among studies.

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Interpretación clínica de la determinación de troponina T de elevada sensibilidad

Cited by 7 publications

References 48 publications

Cardiac Biomarker Release After Exercise in Healthy Children and Adolescents: A Systematic Review and Meta-Analysis

Cardiac Biomarker Release After Exercise in Healthy Children and Adolescents: A Systematic Review and Meta-Analysis

Global research trends on cardiac troponin and physical activity among pediatric populations: a bibliometric analysis and science mapping study

Cardiac Troponin Release after Exercise in Healthy Young Athletes: A Systematic Review

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