Interpositional Augmentation Technique in the Treatment of Posterior Mandibular Atrophies: A Retrospective Study Comparing 129 Autogenous and Heterologous Bone Blocks with 2 to 7 Years Follow-Up

Felice, Pietro; Barausse, Carlo; Barone, Antonio; Zucchelli, Giovanni; Piattelli, M; Pistilli, Roberto; Ippolito, Daniela Rita; Simion, Massimo

doi:10.11607/prd.2999

Cited by 25 publications

(15 citation statements)

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“…This review briefly refers to rigid BGSs, soft sponge-like polyelectrolyte multilayers, microspheres, nanoparticles, and hydrogel. BGSs have been shown to have a great effect on bone regeneration, which is confirmed by clinical trials published in some studies [64]. However, for large-scale bone transplantation, the therapeutic effect is very limited, and the transplantation fails after 5-10 years.…”

Section: Opinionmentioning

confidence: 77%

“…Before the advent of FDA approved synthetic bone transplantation, DBM scaffolds from allogeneic sources accounted for 50% of the total bone grafts. In the broad prospect of bone substitutes, porcine-derived DBM scaffolds also show great effect on human bone regeneration, which has been affirmed by the results of trials published in several studies [64,65]. Moreover, porcine bone scaffolds were also successfully used as BF storage carriers.…”

Section: Rigid Bgs Imprinting Bfsmentioning

confidence: 87%

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Automated Stage Discrimination of Parkinson’s Disease

Aharonson

Seedat

Israeli‐Korn

et al. 2020

BIOI

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Background: Treatment plans for Parkinson’s disease (PD) are based on a disease stage scale, which is generally determined using a manual, observational procedure. Automated, sensor-based discrimination saves labor and costs in clinical settings and may offer augmented stage determination accuracy. Previous automated devices were either cumbersome or costly and were not suitable for individuals who cannot walk without support.Methods: Since 2017, a device has been available that successfully detects PD and operates for people who cannot walk without support. In the present study, the suitability of this device for automated discrimination of PD stages was tested. The device consists of a walking frame fitted with sensors to simultaneously support walking and monitor patient gait. Sixty-five PD patients in Hoehn and Yahr (HY) stages 1 to 4 and 24 heathy controls were subjected to supported Timed Up and Go (TUG) tests, while using the walking frame. The walking trajectory, velocity, acceleration and force were recorded by the device throughout the tests. These physical parameters were converted into symptomatic spatiotemporal quantities that are conventionally used in PD gait assessment.Results: An analysis of variance (ANOVA) test extended by a confidence interval (CI) analysis indicated statistically significant separability between HY stages for the following spatiotemporal quantities: TUG time (p < 0.001), straight line walking time (p < 0.001), turning time (p < 0.001), and step count (p < 0.001). A negative correlation was obtained for mean step velocity (p < 0.001) and mean step length (p < 0.001). Moreover, correlations were established between these, as well as additional spatiotemporal quantities, and disease duration, L-dihydroxyphenylalanine-(L-DOPA) dose, motor fluctuation, dyskinesia and the mobile part of the Unified Parkinson Disease Rating Scale (UPDRS).Conclusions: We have proven that stage discrimination of PD can be automated, even to patients who cannot support themselves. A similar method might be successfully applied to other gait disorders.

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Section: Opinionmentioning

confidence: 77%

Section: Rigid Bgs Imprinting Bfsmentioning

confidence: 87%

Automated Stage Discrimination of Parkinson’s Disease

Aharonson

Seedat

Israeli‐Korn

et al. 2020

BIOI

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“…Other important and specific clinical factors have to be taken into consideration. For instance, the prevalence of peri-implantitis in patients with implants in augmented sites is more variable and less predictable compared with the prevalence in patients with implants in pristine sites [40][41][42][43][44]. There are differences in bone loss during the spontaneous progression period between pristine and augmented: the size and vertical dimension of the peri-implantitis lesion were larger at augmented than at pristine sites and the findings seemed to be confirmed by clinical data, which showed a faster and worsening progression of peri-implantitis in augmented bone [45].…”

Section: Overdentures (Ovd)mentioning

confidence: 99%

A Proposed Protocol for Ordinary and Extraordinary Hygienic Maintenance in Different Implant Prosthetic Scenarios

et al. 2021

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Prevention of peri-implantitis involves the early diagnosis of peri-implant mucositis. This article presents a protocol of hygienic maintenance in different implant prosthetic scenarios: single crown, fixed partial prosthesis, fixed full-arch, and overdentures. Others clinical conditions have to be taken into consideration: patient compliance; history of periodontitis; implants placed in augmented bone; short, zygomatic, pterygoid, and tilted implants; and complex prosthesis with false gingiva. Two levels of implant maintenance are described: ordinary, performed by dental hygienist, and extraordinary, carried out by both dentist and hygienist. Extraordinary maintenance also involves the removal and decontamination of the prosthetic structure. To obtain an effective prevention of peri-implantitis, one must plan ordinary and extraordinary hygiene in relation to the type of rehabilitation and clinical parameters.

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“…Therefore, the ability to perform high quality three-dimensional (3D) mandibular reconstruction is of critical importance [2]. Felice et al [3] followed-up bone grafts in 115 patients with posterior mandibular atrophy for 2–7 years. The outcomes of those with heterologous and autogenous bone blocks were similar; thus, heterologous blocks may be preferable because no invasive harvesting is required.…”

Section: Introductionmentioning

confidence: 99%

Application of a Bioactive/Bioresorbable Three-Dimensional Porous Uncalcined and Unsintered Hydroxyapatite/Poly-D/L-lactide Composite with Human Mesenchymal Stem Cells for Bone Regeneration in Maxillofacial Surgery: A Pilot Animal Study

et al. 2019

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A novel three-dimensional (3D) porous uncalcined and unsintered hydroxyapatite/poly-d/l-lactide (3D-HA/PDLLA) composite demonstrated superior biocompatibility, osteoconductivity, biodegradability, and plasticity, thereby enabling complex maxillofacial defect reconstruction. Mesenchymal stem cells (MSCs)—a type of adult stem cell—have a multipotent ability to differentiate into chondrocytes, adipocytes, and osteocytes. In a previous study, we found that CD90 (Thy-1, cluster of differentiation 90) and CD271 (low-affinity nerve growth factor receptor) double-positive cell populations from human bone marrow had high proliferative ability and differentiation capacity in vitro. In the present study, we investigated the utility of bone regeneration therapy using implantation of 3D-HA/PDLLA loaded with human MSCs (hMSCs) in mandibular critical defect rats. Microcomputed tomography (Micro-CT) indicated that implantation of a 3D-HA/PDLLA-hMSC composite scaffold improved the ability to achieve bone regeneration compared with 3D-HA/PDLLA alone. Compared to the sufficient blood supply in the mandibular defection superior side, a lack of blood supply in the inferior side caused delayed healing. The use of Villanueva Goldner staining (VG staining) revealed the gradual progression of the nucleated cells and new bone from the scaffold border into the central pores, indicating that 3D-HA/PDLLA loaded with hMSCs had good osteoconductivity and an adequate blood supply. These results further demonstrated that the 3D-HA/PDLLA-hMSC composite scaffold was an effective bone regenerative method for maxillofacial boney defect reconstruction.

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Interpositional Augmentation Technique in the Treatment of Posterior Mandibular Atrophies: A Retrospective Study Comparing 129 Autogenous and Heterologous Bone Blocks with 2 to 7 Years Follow-Up

Cited by 25 publications

References 0 publications

Automated Stage Discrimination of Parkinson’s Disease

Automated Stage Discrimination of Parkinson’s Disease

A Proposed Protocol for Ordinary and Extraordinary Hygienic Maintenance in Different Implant Prosthetic Scenarios

Application of a Bioactive/Bioresorbable Three-Dimensional Porous Uncalcined and Unsintered Hydroxyapatite/Poly-D/L-lactide Composite with Human Mesenchymal Stem Cells for Bone Regeneration in Maxillofacial Surgery: A Pilot Animal Study

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