Interposition Vein Cuff and Intimal Hyperplasia: An Experimental Study

Ducasse, Éric; Fleurisse, L.; Vernier, G.; Speziale, Francesco; Fiorani, P; Puppinck, P; Creusy, Collette

doi:10.1016/j.ejvs.2004.03.002

Cited by 14 publications

(12 citation statements)

References 40 publications

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“…We cannot hypothesize whether this layer would continue to develop or regress as the BioWeld 1 device continues to metabolize over time, altering in anastomotic compliance. The intimal layer appears to have developed in an effort to reach luminal hemostasis in a manner similar to that described by Ducasse et al [28]. The BioWeld 1 device is flexible and elastic when hydrated, allowing it to pulsate with the vessel.…”

Section: Discussionmentioning

confidence: 78%

Laser‐assisted end‐to‐end bioweld^® anastomosis in an ovine model

Wright¹,

Vicaretti

Schwaiger³

et al. 2007

Lasers Surg Med

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The BioWeld tube, an albumin-based exovascular stent, has been used for microsurgical anastomoses and compared to conventional sutures. The study presented investigated the potential of the BioWeld tube for vascular anastomosis in larger vessels. Laser-assisted BioWeld anastomoses were compared to conventional-sutured anatomoses of the carotid artery of Merino-x ewes. The BioWeld procedure resulted in 100% survival and 100% patency at 1 and 6 week post-operative periods, with no noticeable foreign body response. Sutured animals showed 100% survival and patency. The ischemic time for BioWeld anastomosis averaged 15 minutes compared with 10 minutes for sutures. This study indicates that the BioWeld tube is an easy to use anastomotic technique with equivalent success rates and comparable anastomotic times.

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Section: Discussionmentioning

confidence: 78%

Laser‐assisted end‐to‐end bioweld^® anastomosis in an ovine model

Wright¹,

Vicaretti

Schwaiger³

et al. 2007

Lasers Surg Med

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“…30,40 However, some studies have reported an increase in intimal hyperplasia in cuffed junctions. 7 These studies have reported that the benefit of cuffs and patches may be in serving an increase in the junction volume into which intimal hyperplasia thickening may take place. Therefore, while the cuffs may serve to increase the junction volume, they may increase the rate of intimal hyperplasia development.…”

Section: Scope Of the Studymentioning

confidence: 98%

On Reducing Abnormal Hemodynamics in the Femoral End-to-Side Anastomosis: The Influence of Mechanical Factors

2005

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This study was concerned with investigating the influence of mechanical factors on the hemodynamics of the end-to-side anastomosis in an attempt to identify critical factors and establish if it is possible to re-engineer existing, patient-specific, by-pass grafts with a view to increasing their patency. The study chose the femoral artery as the principal subject of interest. Wall shear stresses (WSS) and wall shear stress gradients (WSSG) were taken as the primary quantities of interest. Angle, graft calibre, interposition cuffs, proximal outflow and inlet waveform were studied. The study found that the use of cuffs and patches can significantly reduce abnormal WSS and WSSG by up to 70% when compared to a benchmark 45 degrees conventional anastomosis. The Taylor patch was found to be more robust in reducing peak WSS magnitudes and gradients than the Miller cuff, where design variables proved to be more critical. On the addition of a Taylor patch to a realistic end-to-side femoral anastomosis, the peak WSS and WSSG were found to be reduced by 27% and 57%, respectively. In conclusion, it is possible to use idealised models to identify critical disease influencing factors and to use these findings to reduce the effects of abnormal hemodynamics in realistic, patient-dependant models.

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“…Using decellularized and cross‐linked porcine aortic allografts, we compared the efficacy and patency of three groups of grafts: in addition to the uncoated group (Control), the second group contained grafts laminated with PDLLA alone (PDLLA) and the third contained grafts laminated with a PDLLA coating to which lepirudin had been added (PDLLA‐Lep) 23–25. The allogenic porcine model was selected because of the similarity between porcine and human coagulation systems and in consideration of the fact that pigs produce a reliable intimal hyperplasic response.…”

Section: Introductionmentioning

confidence: 99%

Polymer coating of porcine decellularized and cross‐linked aortic grafts

et al. 2010

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This article investigates a method of modifying and optimizing the biocompatibility of decellularized vascular bioimplants when treated with a specialized, drug eluting coating. For this purpose, we carried out aortic transplantations using a porcine model. Decellularized, cross-linked aortic grafts were coated with poly(D,L-lactide) (PDLLA). To this coating, we added the anticoagulant drug lepirudin which, following transplantation, would be linearly eluted. These aortic grafts are easily manipulated in surgery. It was shown that, as a result of the lepirudin-eluting coating, the rate of thrombogenesis was reduced and the patency rate was significantly improved. However, lumen-stenosing pseudointima developed in all of the transplants and was not effected by PDLLA coating. Furthermore, no evidence of recellularisation was documented. This trial demonstrates that polymer coating of decellularized tissue is possible. Neointimal hyperplasia and the absence of cellular repopulation mark the negative consequences of this concept.

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Interposition Vein Cuff and Intimal Hyperplasia: An Experimental Study

Abstract: An interposition vein cuff at the distal anastomosis between a prosthesis and an artery alters the distribution of intimal hyperplasia. By acting as an expansion chamber where intimal hyperplasia can develop harmlessly, the vein cuff may protect the arterial anastomosis from stenosis.

Cited by 14 publications

References 40 publications

Laser‐assisted end‐to‐end bioweld^® anastomosis in an ovine model

Laser‐assisted end‐to‐end bioweld^® anastomosis in an ovine model

On Reducing Abnormal Hemodynamics in the Femoral End-to-Side Anastomosis: The Influence of Mechanical Factors

Polymer coating of porcine decellularized and cross‐linked aortic grafts

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Interposition Vein Cuff and Intimal Hyperplasia: An Experimental Study

Abstract: An interposition vein cuff at the distal anastomosis between a prosthesis and an artery alters the distribution of intimal hyperplasia. By acting as an expansion chamber where intimal hyperplasia can develop harmlessly, the vein cuff may protect the arterial anastomosis from stenosis.

Cited by 14 publications

References 40 publications

Laser‐assisted end‐to‐end bioweld® anastomosis in an ovine model

Laser‐assisted end‐to‐end bioweld® anastomosis in an ovine model

On Reducing Abnormal Hemodynamics in the Femoral End-to-Side Anastomosis: The Influence of Mechanical Factors

Polymer coating of porcine decellularized and cross‐linked aortic grafts

Contact Info

Product

Resources

About

Laser‐assisted end‐to‐end bioweld^® anastomosis in an ovine model

Laser‐assisted end‐to‐end bioweld^® anastomosis in an ovine model