Interpolymer complexes of carbopol® 971 and poly(2-ethyl-2-oxazoline): Physicochemical studies of complexation and formulations for oral drug delivery

Abstract

Reading's research outputs online Interpolymer complexes of Carbopol ® 971 and poly(2-ethyl-2-oxazoline): physicochemical studies of complexation and formulations for oral drug delivery

Interfacial Effects and the Nano-Scale Disruption in Adsorbed-Layer of Acrylate Polymer-Tween 80 Fabricated Steroid-Bearing Emulsions: A Rheological Study of Supramolecular Materials

“…This is a function of the capacity of ‘short and streamline’ molecules to form compact structures and lateral firm lateral packing or associations at the interface [ 26 , 27 ]. This is important when considering the chemical nature of adsorbed polymers such as carbopols [ 23 , 30 , 31 , 32 , 33 , 34 ].…”

“…The functionality of carbopols when used for gels as suspending agents [ 23 ], in interacting with fragrance or hydrophobe molecules [ 26 ], non-ionic emulsifiers [ 31 ], anionic surfactants [ 34 ], drugs and sterane sex hormones such as estrogen [ 32 ] and through molecular interactions or micelle forming polyelectrolyte or hydrophilic polymers used for drug delivery and gene therapy of the polyoxazoline class through hydrogen bonding has been investigated [ 33 ] at some length. Given the nature of the carbopol molecular skeleton and voluminous polar Tween 80 headgroup, electrostatic or hydrogen-bond like interaction based on the development of partial charges between polymer and surfactant is highly likely [ 5 , 13 , 19 , 22 ].…”

Unravelling the Miscibility of Poly(2-oxazoline)s: A Novel Polymer Class for the Formulation of Amorphous Solid Dispersions

“…An interesting polymer class to further explore the potential of combining a water-soluble and insoluble carrier in an ASD are the poly(2-alkyl-2-oxazoline)s (PAOx). The use of this polymer class in the field of ASDs has been reported by Claeys et al [ 11 ], Policianova et al [ 12 ], Fael et al [ 13 ], Ruiz-Rubio et al [ 14 ], Abilova et al [ 15 ], Moustafine et al [ 16 ] and Boel et al [ 17 ]. One of the most important advantages of this polymer class is that its physicochemical properties such as glass transition temperature (T g ), solubility and mechanical strength can easily be altered by adjusting the side chain of the 2-oxazoline monomer or by end-group functionalization [ 18 , 19 , 20 ].…”

Chitosan/Poly(2-ethyl-2-oxazoline) Films with Ciprofloxacin for Application in Vaginal Drug Delivery

“…Poly(2-ethyl-2-oxazoline) is one of the representatives of poly(2-oxazolines) family that is a non-ionic water-soluble polymer available commercially. The application of this material in the design of dosage forms for drug delivery has received a substantial interest in the last few years and it is often viewed as a potential alternative pharmaceutical excipient to well-established water-soluble polymers [25][26][27][28].…”