Interpolymer complexation between polyacrylic acid and cellulose ethers: Formation and properties

Николаева, О. В.; Budtova, Tatiana; Alexeev, V.L.; Frenkel, S.Ya.

doi:10.1002/(sici)1099-0488(20000515)38:10<1323::aid-polb80>3.0.co;2-b

Cited by 34 publications

(33 citation statements)

References 10 publications

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“…A rough method assesses the contribution of H-bonding to the pH of a mixture by comparing the pH of the polyacid/neutral polymer mixture with that of a polyacid solution at the same concentration. [4] The deviation of the pH value of the MAc-S/HPC aqueous mixtures from that of its corresponding MAc-S aqueous solution represents the H-bonding contribution to the pH of the mixture. Additionally, the fraction of binding groups (or the degree of complexation) involved in the complex formation could be roughly estimated from potentiometric data as follows: [44] y…”

Section: Potentiometrymentioning

confidence: 99%

“…[2,3] During the last few years the researcher's interest have been caught by the intermacromolecular associations between synthetic/natural polymers e.g., poly(acrylic acid) with methyl, hydroxyethyl or hydroxypropyl cellulose. [4][5][6][7][8][9][10] The ability of some copolymers of maleic acid with different co-monomers i.e., vinyl acetate, acrylic acid and styrene to form interpolymeric complexes with hydroxypropyl cellulose (HPC) was studied. [11] The investigation of the interpolymer complex (IPC) formation between a synthetic polymer and a biological macromolecule could be a stage further in macromolecular association studies both from theoretical and experimental point of view.…”

Section: Introductionmentioning

confidence: 99%

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Investigation of the Interpolymer Complex between Hydroxypropyl Cellulose and Maleic Acid‐Styrene Copolymer, 1

Bumbu

Vasile²,

Eckelt

et al. 2004

Macro Chemistry & Physics

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Summary: The hydrogen bonding‐interpolymer association of hydroxypropyl cellulose (HPC) with maleic acid‐styrene (MAc‐S) copolymer has been investigated in dilute aqueous solution by viscometry, turbidimetry and potentiometry. At a mixing ratio between MAc‐S and HPC of 10:90, the solution exhibits a phase separation upon heating, while for other mixing ratio no phase separation could be detected. The stability of the interpolymer complex (IPC) increases as the temperature rises. The stoichiometry of the IPC, in mole units, was estimated as being MAc‐S:HPC = 5:2. The thermodynamic functions (enthalpy and entropy) of the complexation process have been determined.

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Section: Potentiometrymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Investigation of the Interpolymer Complex between Hydroxypropyl Cellulose and Maleic Acid‐Styrene Copolymer, 1

Bumbu

Vasile²,

Eckelt

et al. 2004

Macro Chemistry & Physics

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“…Specific interactions have also been reported in blends between poly(acrylic acid) (PAA) and various water-soluble polysaccharides. [3,[10][11][12][13][14][15] Complete miscibility as a rule is attributed to the strong intermacromolecular hydrogen bonding between the component polymers. Studies on blends of water-soluble polysaccharides and carboxylic acid copolymers containing the groups, which are not able to form hydrogen bonds, are quite limited.…”

Section: Introductionmentioning

confidence: 99%

Characterisation of Blends Based on Hydroxyethylcellulose and Maleic Acid‐alt‐Methyl Vinyl Ether

Khutoryanskaya

Khutoryanskiy

Pethrick

2005

Macro Chemistry & Physics

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Summary: Hydrophilic polymeric films based on blends of hydroxyethylcellulose and maleic acid‐co‐methyl vinyl ether were produced by casting from aqueous solutions. The physicochemical properties of the blends have been assessed using Fourier transform infrared spectroscopy, thermal gravimetric analysis, differential scanning calorimetry, dielectric spectroscopy, etc. The pristine films exhibit complete miscibility due to the formation of intermacromolecular hydrogen bonding. The thermal treatment of the blend films leads to cross‐linking via intermacromolecular esterification and anhydride formation. The cross‐linked materials are able to swell in water and their swelling degree can be easily controlled by temperature and thermal treatment time. The formation of the crosslinks is apparent in the dynamic properties of the blends as observed through the mechanical relaxation and dielectric relaxation spectra. The dielectric characteristics of the material are influenced by the effects of change in the local structure of the blend on the ionic conduction processes and the rate of dipolar relaxation. Separation of these processes is attempted using the dielectric modulus method. Significant deviations from a simple additive rule of mixing on the activation energy are observed consistent with hydrogen bonding and crosslinking of the matrix. This paper indicates a method for the creation of films with good mechanical and physical characteristics by exposing the blends to a relatively mild thermal treatment.

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“…PENPs have demonstrated great potential in biomedical and nano-biotechnological applications, including controlled drug release, good biocompatibility, and gene transfection. 8 In this study, chitosan hydrochloride (HCS) was chosen as the cationic material owing to the abundance of positively charged terminal amine groups and better water solubility than chitosan (CS). Hyaluronic acid (HA) was chosen as the polyanion due to its negative charge in neutral and alkaline environments and tumor-targeting property through specific binding to the CD44 molecule, an integral membrane glycoprotein overexpressed on the surface of various tumor cells.…”

Section: Introductionmentioning

confidence: 99%

Polysaccharide-based nanoparticles for co-loading mitoxantrone and verapamil to overcome multidrug resistance in breast tumor

Xu¹,

Asghar²,

Gao³

et al. 2017

IJN

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The aim of this study was to evaluate the potential of polyelectrolyte complex nanoparticles (PENPs) based on hyaluronic acid/chitosan hydrochloride (HA/HCS) for co-loading mitoxantrone (MTO) and verapamil (VRP) to overcome multidrug resistance in breast tumors. PENPs co-loaded with MTO and VRP (MTO-VRP-PENPs) were affected by the method of preparation, molecular weight of HA, mass ratios and initial concentrations of HA/HCS, pH, and drug quantities. Optimized MTO-VRP-PENPs were ~209 nm in size with a zeta potential of approximately −24 mV. Encapsulation efficiencies (%) of MTO and VRP were 98.33%±0.27% and 44.21%±8.62%, respectively. MTO and VRP were successfully encapsulated in PENPs in a molecular or amorphous state. MTO-VRP-PENPs showed significant cytotoxicity in MCF-7/ADR cells in contrast to MTO-loaded PENPs (MTO-PENPs). The reversal index of MTO-VRP-PENPs was 13.25 and 10.33 times greater than that of the free MTO and MTO-PENPs, respectively. In conclusion, MTO-VRP-PENPs may serve as a promising carrier to overcome tumor drug resistance.

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Interpolymer complexation between polyacrylic acid and cellulose ethers: Formation and properties

Cited by 34 publications

References 10 publications

Investigation of the Interpolymer Complex between Hydroxypropyl Cellulose and Maleic Acid‐Styrene Copolymer, 1

Investigation of the Interpolymer Complex between Hydroxypropyl Cellulose and Maleic Acid‐Styrene Copolymer, 1

Characterisation of Blends Based on Hydroxyethylcellulose and Maleic Acid‐alt‐Methyl Vinyl Ether

Polysaccharide-based nanoparticles for co-loading mitoxantrone and verapamil to overcome multidrug resistance in breast tumor

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