Interplay of reactive oxygen species (ROS) and tissue engineering: a review on clinical aspects of ROS-responsive biomaterials

Tyagi, Nishant; Gambhir, Kirtida; Kumar, Subodh; Gangenahalli, Gurudutta; Verma, Yogesh Kumar

doi:10.1007/s10853-021-06338-7

Cited by 20 publications

(12 citation statements)

References 240 publications

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“…38 ROS, including single oxygen ( 1 O 2 ), hydroxyl radicals (˙OH), superoxide radicals (O 2 ˙ − ), and peroxides (O 2 2− ), can functionally regulate cell signaling, adhesion, and migration at a lower concentration. 39 Nevertheless, increased levels of ROS could lead to irreversible vital organ or DNA damage. 39 Cancer cells, compared to normal cells, produce a large amount of ROS to maintain their malignant phenotype and are more vulnerable to exogenous ROS-mediated damage.…”

Section: Photodynamic Therapy (Pdt)mentioning

confidence: 99%

Functional anti-bone tumor biomaterial scaffold: construction and application

et al. 2023

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Section: Photodynamic Therapy (Pdt)mentioning

confidence: 99%

Functional anti-bone tumor biomaterial scaffold: construction and application

et al. 2023

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“…However, loss of the skin’s self-healing capacity may lead to a major physiological imbalance, which can result in difficulty in wound healing conditions [ 2 ]. This can be altered by the application of skin and tissue engineering techniques [ 3 , 4 ]. Burn wounds, on the other hand, are highly complex wounds and require different approaches for treatment ( Figure S2 , see online supplementary material).…”

Section: Introductionmentioning

confidence: 99%

Polymeric biomaterials-based tissue engineering for wound healing: a systemic review

et al. 2023

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Background Biomaterials are vital products used in clinical sectors as alternatives to several biological macromolecules for tissue engineering techniques owing to their numerous beneficial properties, including wound healing. The healing pattern generally depends upon the type of wounds, and restoration of the skin on damaged areas is greatly dependent on the depth and severity of the injury. The rate of wound healing relies on the type of biomaterials being incorporated for the fabrication of skin substitutes and their stability in in vivo conditions. In this review, a systematic literature search was performed on several databases to identify the most frequently used biomaterials for the development of successful wound healing agents against skin damage, along with their mechanisms of action. Method The relevant research articles of the last 5 years were identified, analysed and reviewed in this paper. The meta-analysis was carried out using PRISMA and the search was conducted in major scientific databases. The research of the most recent 5 years, from 2017–2021 was taken into consideration. The collected research papers were inspected thoroughly for further analysis. Recent advances in the utilization of natural and synthetic biomaterials (alone/in combination) to speed up the regeneration rate of injured cells in skin wounds were summarised. Finally, 23 papers were critically reviewed and discussed. Results In total, 2022 scholarly articles were retrieved from databases utilizing the aforementioned input methods. After eliminating duplicates and articles published before 2017, ~520 articles remained that were relevant to the topic at hand (biomaterials for wound healing) and could be evaluated for quality. Following different procedures, 23 publications were selected as best fitting for data extraction. Preferred Reporting Items for Systematic Reviews and Meta-Analyses for this review illustrates the selection criteria, such as exclusion and inclusion parameters. The 23 recent publications pointed to the use of both natural and synthetic polymers in wound healing applications. Information related to wound type and the mechanism of action has also been reviewed carefully. The selected publication showed that composites of natural and synthetic polymers were used extensively for both surgical and burn wounds. Extensive research revealed the effects of polymer-based biomaterials in wound healing and their recent advancement. Conclusions The effects of biomaterials in wound healing are critically examined in this review. Different biomaterials have been tried to speed up the healing process, however, their success varies with the severity of the wound. However, some of the biomaterials raise questions when applied on a wide scale because of their scarcity, high transportation costs and processing challenges. Therefore, even if a biomaterial has good wound healing qualities, it may be technically unsuitable for use in actual medical scenarios. All of these restrictions have been examined closely in this review.

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“…In this regard, reactive oxygen species (ROS), which is the term given to biologically relevant oxidants present in the human body as by-products of aerobic respiration, including hydrogen peroxide (H 2 O 2 ), the superoxide anion (O 2 ˙ − ), hydroxyl radical (˙OH), peroxynitrite (ONOO − ), single oxygen ( 1 O 2 ), and hypochlorite (OCl − ), has gained great importance in the last decade. 13 ROS can be produced endogenously, from incomplete reduction of oxygen and the enzyme NADPH oxidase in the plasma membrane, or through exogenous stimuli such as UV light, ionizing radiation, and xenobiotics. 14 It is worth noting the highly concentration-dependent ROS role ranging from beneficial cell survival to non-desirable effects.…”

Section: Introductionmentioning

confidence: 99%