Interplay of RAP2 GTPase and the cytoskeleton in Hippo pathway regulation
Chenzhou Wu,
Xiaomin Cai,
Ying Wang
et al.
Abstract:The Hippo signaling is instrumental in regulating organ size, regeneration, and carcinogenesis. The cytoskeleton emerges as a primary Hippo signaling modulator. Its structural alterations in response to environmental and intrinsic stimuli control Hippo kinase cascade activity. However, the precise mechanisms underlying the cytoskeleton regulation of Hippo signaling are not fully understood. RAP2 GTPase is known to mediate the mechanoresponses of Hippo signalingviaactivating the core Hippo kinases LATS1/2 throu… Show more
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