Interplay of nitric oxide metabolites and markers of endothelial injury, inflammation, and vascular disease in the spectrum of advanced chronic kidney disease

Batko, Krzysztof; Krzanowski, Marcin; Pietrzycka, Agata; Gajda, Mariusz; Dumnicka, Paulina; Fedak, Danuta; Gołasa, Paulina; Woziwodzka, Karolina; Jaśkowski, Piotr; Sułowicz, Władysław; Kuźniewski, Marek; Litwin, Jan A.; Krzanowska, Katarzyna

doi:10.33963/kp.15065

Cited by 8 publications

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“…In this study, we reported that HGWWD treatment significantly restored aortic vascular endothelial dysfunction through NO signaling (Figure 3). Abnormal NO levels have been reported in vascular pathological conditions (Bondonno et al, 2016), and intervention in NO signaling can effectively prevent various vascular disorders, including endothelial dysfunction, vascular inflammation and vascular stiffness (Bondonno et al, 2016;Batko et al, 2019;Chen et al, 2019). Furthermore, excessive arginase activation can down-regulate NO production by reducing NOS availability through competition for their common substrate L-arginine (Bhatta et al, 2017;Zhou et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

HuangqiGuizhiWuwu Decoction Prevents Vascular Dysfunction in Diabetes via Inhibition of Endothelial Arginase 1

et al. 2020

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Hyperglycemia induces vascular endothelial dysfunction, which contributes to the development of vascular complication of diabetes. A classic prescription of traditional medicine, HuangqiGuizhiWuwu Decoction (HGWWD) has been used for the treatment of various cardiovascular and cerebrovascular diseases, which all are related with vascular pathology. The present study investigated the effect of HGWWD treatment in streptozocin (STZ)-induced vascular dysfunction in mouse models. In vivo studies were performed using wild type mice as well as arginase 1 knockout specific in endothelial cells (EC-A1 −/−) of control mice, diabetes mice and diabetes mice treated with HGWWD (60 g crude drugs/kg/d) for 2 weeks. For in vitro studies, aortic tissues were treated with mice serum containing HGWWD with or without adenoviral arginase 1 (Ad-A1) transduction in high glucose (HG) medium. We found that HGWWD treatment restored STZ-induced impaired mean velocity and pulsatility index of mouse left femoral arteries, aortic pulse wave velocity and vascular endothelial relaxation accompanied by elevated NO production in the aorta and plasma, as well as reduced endothelial arginase activity and aortic arginase 1 expression. The protective effect of HGWWD is reversed by an inhibitor of nitric oxide synthesis. Meanwhile, the preventive effect of serum containing HGWWD in endothelial vascular dysfunction is completely blocked by Ad-A1 transduction in HG incubated aortas. HGWWD treatment further improved endothelial vascular dysfunction in STZ induced EC-A1 −/− mice. This study demonstrates that HGWWD improved STZ-induced vascular dysfunction through arginase 1-NO signaling, specifically targeting endothelial arginase 1.

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Section: Discussionmentioning

confidence: 99%

HuangqiGuizhiWuwu Decoction Prevents Vascular Dysfunction in Diabetes via Inhibition of Endothelial Arginase 1

et al. 2020

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“…Nair and colleagues demonstrated decreased maximal FMD and increased IMT values in diabetic patients compared to controls [41]. Impairment of these parameters may precede diabetic vascular complications [41] and associate with NOx level in chronic renal failure [42], while FMD negatively correlates with the number of complications in diabetic subjects [43]. The above studies emphasize the need for detailed characterization of both genetic and environmental factors influencing FMD and IMT in T2DM patients.…”

Section: Discussionmentioning

confidence: 98%

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase p22phox subunit polymorphisms, systemic oxidative stress, endothelial dysfunction, and atherosclerosis in type 2 diabetes mellitus

Osmenda

Matusik

Śliwa

et al. 2021

Polish Archives of Internal Medicine

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This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (CC BY-NC-SA 4.0), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited, distributed under the same license, and used for noncommercial purposes only.

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“…The influence of CRP weakens the activity and expression of endothelial nitric oxide synthase, and the production of nitric oxide is inhibited. In terms of CAC and angiogenesis, nitric oxide plays a key role ( Batko et al, 2020 ). Therefore, when CKD patients have high hs-CRP values, it may be due to a sharp decrease in the amount of nitric oxide and abnormal endothelial function (CRP-mediated).…”

Section: Discussionmentioning

confidence: 99%

Association between fibrinogen/albumin ratio and severity of coronary artery calcification in patients with chronic kidney disease: a retrospective study

Zhu

Tao

Zhang

et al. 2022

PeerJ

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Aim Previous studies have shown that the fibrinogen to albumin ratio (FAR) is closely related to the severity and prognosis of coronary atherosclerosis. In this study, we sought to evaluate the association between FAR and the degree of coronary artery calcification (CAC) in patients with chronic kidney disease (CKD). Methods In this retrospective study, 218 patients with CKD were stratified into low, medium and high FAR groups according to the tertiles of the FAR values. The CAC scores, clinical information and laboratory test results of the three FAR groups were compared. To explore the relationship between FAR and CAC we conducted binary logistic regression and correlation analyses. Results In the low FAR group, the CAC scores were significantly lower than those in the medium and high FAR groups (P < 0.001). There was a significant correlation between the FAR and CAC scores (r = 0.510, P < 0.001). The FAR was an independent predictor of CAC (OR = 1.106, 95% CI [1.004–1.218], P = 0.042). Conclusion In patients with CKD, the FAR can be considered as an effective predictor of CAC.

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Interplay of nitric oxide metabolites and markers of endothelial injury, inflammation, and vascular disease in the spectrum of advanced chronic kidney disease

Cited by 8 publications

References 0 publications

HuangqiGuizhiWuwu Decoction Prevents Vascular Dysfunction in Diabetes via Inhibition of Endothelial Arginase 1

HuangqiGuizhiWuwu Decoction Prevents Vascular Dysfunction in Diabetes via Inhibition of Endothelial Arginase 1

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase p22phox subunit polymorphisms, systemic oxidative stress, endothelial dysfunction, and atherosclerosis in type 2 diabetes mellitus

Association between fibrinogen/albumin ratio and severity of coronary artery calcification in patients with chronic kidney disease: a retrospective study

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