Interplay of motility and polymer-driven depletion forces in the initial stages of bacterial aggregation

Porter, Michael K.; Steinberg, Asher Preska; Ismagilov, Rustem F.

doi:10.1039/c9sm00791a

Cited by 20 publications

(17 citation statements)

References 53 publications

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“…Regardless, the features of the observed phase separation depend on the rate at which EPS particles are produced. More recent results have also highlighted the interplay between motility and depletion-like interactions [31].…”

Section: Extracellular Polymeric Substancesmentioning

confidence: 96%

In-silico modeling of early-stage biofilm formation

et al. 2021

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Several bacteria and bacteria strands form biofilms in different environmental conditions, e.g. pH, temperature, nutrients, etc. Biofilm growth, therefore, is an extremely robust process. Because of this, while biofilm growth is a complex process affected by several variables, insights into biofilm formation could be obtained studying simple schematic models. In this manuscript, we describe a hybrid molecular dynamics and Monte Carlo model for the simulation of the early stage formation of a biofilm, to explicitly demonstrate that it is possible to account for most of the processes expected to be relevant. The simulations account for the growth and reproduction of the bacteria, for their interaction and motility, for the synthesis of extracellular polymeric substances and Psl trails. We describe the effect of these processes on the early stage formation of biofilms, in two dimensions, and also discuss preliminary three-dimensional results.

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Section: Extracellular Polymeric Substancesmentioning

confidence: 96%

In-silico modeling of early-stage biofilm formation

et al. 2021

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“…Different types of synthesized cationic polymers have been reported to induce bacterial aggregation through electrostatic interactions, stimulating subsequent quorum sensing associated bioluminescence as well as improving the efficacy of antibiotics. 22,23,69,70 Polymer-protected bacteria have been demonstrated as genecarriers for orally administered DNA vaccines, showing promising efficacy for cancer immunotherapy. 71 In the case of hydrophobic interactions, Gram-positive and Gram-negative bacteria act differently when interacting with functional materials containing hydrophobic anchors.…”

Section: Artificial Surface Ligands and Interactionsmentioning

confidence: 99%

Engineering bacterial surface interactions using DNA as a programmable material

Kong

et al. 2022

Chem. Commun.

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“…As a result, the unbalanced osmotic pressure of the solution forces the cells together. This attractive depletion interaction can drive the aggregation of both non-motile and motile cells in a manner similar to passive colloidal particles 166,193 , although the swimming stress generated by motile cells suppresses aggregation 194 . Intriguingly, for the case of motile cells, the finite size aggregates that form via depletion interactions show unidirectional rotation, driven by the torques exerted by the bacteria at the outer periphery of each aggregate 195 .…”

Section: B Viscoelastic Polymer Solutionsmentioning

confidence: 99%

Active transport in complex environments

Martínez-Calvo¹,

Trenado-Yuste²,

Datta³

2021

Preprint

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The ability of many living systems to actively self-propel underlies critical biomedical, environmental, and industrial processes. While such active transport is well-studied in uniform settings, environmental complexities such as geometric constraints, mechanical cues, and external stimuli such as chemical gradients and fluid flow can strongly influence transport. In this chapter, we describe recent progress in the study of active transport in such complex environments, focusing on two prominent biological systems-bacteria and eukaryotic cells-as archetypes of active matter. We review research findings highlighting how environmental factors can fundamentally alter cellular motility, hindering or promoting active transport in unexpected ways, and giving rise to fascinating behaviors such as directed migration and large-scale clustering. In parallel, we describe specific open questions and promising avenues for future research. Furthermore, given the diverse forms of active matterranging from enzymes and driven biopolymer assemblies, to microorganisms and synthetic microswimmers, to larger animals and even robots-we also describe connections to other active systems as well as more general theoretical/computational models of transport processes in complex environments. * Preprint of a chapter in the book Out-of-Equilibrium Soft Matter: Active Fluids, to be published by the Royal Society of Chemistry.

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Interplay of motility and polymer-driven depletion forces in the initial stages of bacterial aggregation

Abstract: Counterintuitively, bacterial motility aids polymer-driven depletion aggregation at short time scales by enabling collisions in viscous solutions.

Cited by 20 publications

References 53 publications

In-silico modeling of early-stage biofilm formation

In-silico modeling of early-stage biofilm formation

Engineering bacterial surface interactions using DNA as a programmable material

Active transport in complex environments

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