Interplay of Human Gut Microbiome in Health and Wellness

Singhvi, N. R.; Gupta, Vipin; Gaur, Mohita; Sharma, Vishal; Puri, Akshita; Singh, Yogendra; Dubey, Gyanendra P.; Lal, Rup

doi:10.1007/s12088-019-00825-x

Cited by 46 publications

(34 citation statements)

References 95 publications

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“…Various studies have reported the association of dysbiosis with the pathogenesis of various intestinal or extra-intestinal disorders such as coeliac disease, cardiovascular disease, diabetes, and obesity [ 9 , 41 ]. Similarly, Kedia et al [ 7 ] have reported comparable changes in the gut microbiome of patients suffering from autoimmune (Inflammatory Bowel Disease, IBD) as well as infectious diseases, suggesting the role of inflammation in the altered status of the gut microbiome.…”

Section: Diet Induced Dysbiosis Inflammation and Comorbiditymentioning

confidence: 99%

Diet, Gut Microbiota and COVID-19

et al. 2020

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Worldwide, millions of individuals have been affected by the prevailing SARS-CoV-2. Therefore, a robust immune system remains indispensable, as an immunocompromised host status has proven to be fatal. In the absence of any specific antiviral drug/vaccine, COVID-19 related drug repurposing along with various other nonpharmacological measures coupled with lockdown have been employed to combat this infection. In this context, a plant based rich fiber diet, which happens to be consumed by a majority of the Indian population, appears to be advantageous, as it replenishes the host gut microbiota with beneficial microbes thereby leading to a symbiotic association conferring various health benefits to the host including enhanced immunity. Further, implementation of the lockdown which has proven to be a good non-pharmacological measure, seems to have resulted in consumption of home cooked healthy diet, thereby enriching the beneficial microflora in the gut, which might have resulted in better prognosis of COVID-19 patients in India in comparison to that observed in the western countries.

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Section: Diet Induced Dysbiosis Inflammation and Comorbiditymentioning

confidence: 99%

Diet, Gut Microbiota and COVID-19

et al. 2020

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“…Gut microbes play important roles in metabolic diseases and can directly or indirectly affect lipid metabolism. However, the exact mechanism of these interactions remains unclear (6). As early as 1963, probiotics were found to have a cholesterol-lowering effect in humans (7,8).…”

Section: Introductionmentioning

confidence: 99%

Novel Lactobacillus reuteri HI120 Affects Lipid Metabolism in C57BL/6 Obese Mice

et al. 2020

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Intestinal probiotics are a primary focus area of current medical research. Probiotics such as bifidobacteria and lactobacilli can positively impact obesity and other metabolic diseases by directly or indirectly affecting lipid metabolism. However, the precise mechanisms of these effects remain unclear. In our previous work, the novel strain Lactobacillus reuteri HI120 was isolated and identified. HI120 expresses high levels of linoleic isomerase, resulting in the production of large amounts of conjugated linoleic acid (CLA) when mixed with linoleic acid (LA). As HI120 can efficiently transform LA into CLA, the effect of HI120 on the lipid metabolism in C57BL/6 obese mice was studied and the underlying molecular mechanism was explored in vitro. The results revealed no significant change in the diet, body weight, and serum triglyceride levels in mice. However, serum cholesterol levels were significantly decreased. The underlying mechanism may involve a CLA-mediated reduction in the gene expression levels of NPC1L1, SREBP-2, and HMG-CR, resulting in reduced cholesterol synthesis and absorption. Thus, HI120 can be developed as a potential probiotic formulation. After oral administration, LA from certain food sources can be converted into CLA in the human intestine to contribute to the prevention and treatment of obesity and hyperlipidemia.

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Section: The Importance Of Gut Microbiome To Good Healthmentioning

confidence: 99%

“…The importance of gut microbiome to health is well-documented [ 1 , 5 , 6 ]. For example, research shows that short-chain fatty acid produced by gut microbiota fermentation alleviates type 2 diabetes mellitus [ 1 , 6 ]. Gut microbiota also has positive contribution to the host defence against pneumonia [ 6 ], and may contribute to super longevity [ 1 ].…”

Section: The Importance Of Gut Microbiome To Good Healthmentioning

confidence: 99%

Restoring Good Health in Elderly with Diverse Gut Microbiome and Food Intake Restriction to Combat COVID-19

2021

Indian J Microbiol

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Interplay of Human Gut Microbiome in Health and Wellness

Cited by 46 publications

References 95 publications

Diet, Gut Microbiota and COVID-19

Diet, Gut Microbiota and COVID-19

Novel Lactobacillus reuteri HI120 Affects Lipid Metabolism in C57BL/6 Obese Mice

Restoring Good Health in Elderly with Diverse Gut Microbiome and Food Intake Restriction to Combat COVID-19

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