Interplay between serotonin and cannabinoid function in the amygdala in fear conditioning

Nasehi, Mohammad; Davoudi, Kamelia; Ebrahimi-Ghiri, Mohaddeseh; Zarrindast, Mohammad‐Reza

doi:10.1016/j.brainres.2016.01.034

Cited by 12 publications

(10 citation statements)

References 49 publications

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“…In line with our results, plethora of evidence reporting that activation of 5-HT4 receptors ameliorates cognitive impairments [5]. In addition, a modulatory effect for RS23597 on ACPA response in auditory fear conditioning has been reported in our laboratory [27]. A highly specialized neuromodulatory role for 5-HT4 receptors in synaptic plasticity and hippocampus-dependent cognition has been proposed [5].…”

Section: Discussionsupporting

confidence: 88%

“…Accumulating evidence suggests that there is an interaction between CB1Rs and the 5-HT neuronal system [2,13]. We previously reported the involvement of 5-HT4 receptors in learning deficits induced by activation of CB1Rs in passive avoidance step-down task [26] and fear conditioning apparatus [27]. As we know these tasks are dependent upon the encoding and retrieval of emotionally aversive and inherently stressful training events.…”

Section: Introductionmentioning

confidence: 96%

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Interaction between hippocampal serotonin and cannabinoid systems in reactivity to spatial and object novelty detection

Nasehi

Rostam-Nezhad

Ebrahimi-Ghiri

et al. 2017

Behavioural Brain Research

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Functional interaction between cannabinoid and serotonin neuronal systems have been reported in different tasks related to memory assessment. The present study investigated the effect of serotonin 5-HT4 agents into the dorsal hippocampus (the CA1 region) on spatial and object novelty detection deficits induced by activation of cannabinoid CB1 receptors (CB1Rs) using arachidonylcyclopropylamide (ACPA) in a non-associative behavioral task designed to forecast the ability of rodents to encode spatial and non-spatial relationships between distinct stimuli. Post-training, intra-CA1 microinjection of 5-HT4 receptor agonist RS67333 or 5-HT4 receptor antagonist RS23597 both at the dose of 0.016μg/mouse impaired spatial memory, while cannabinoid CB1R antagonist AM251 (0.1μg/mouse) facilitated object novelty memory. Also, post-training, intraperitoneal administration of CB1R agonist ACPA (0.005-0.05mg/kg) impaired both memories. However, a subthreshold dose of RS67333 restored ACPA response on both memories. Moreover, a subthreshold dose of RS23597 potentiated ACPA (0.01mg/kg) and reversed ACPA (0.05mg/kg) responses on spatial memory, while it potentiated ACPA response at the dose of 0.005 or 0.05mg/kg on object novelty memory. Furthermore, effective dose of AM251 restored ACPA response at the higher dose. AM251 blocked response induced by combination of RS67333 or RS23597 and the higher dose of ACPA on both memories. Our results highlight that hippocampal 5-HT4 receptors differently affect cannabinoid signaling in spatial and object novelty memories. The inactivation of CB1 receptors blocks the effect of 5-HT4 agents into the CA1 region on memory deficits induced by activation of CB1Rs via ACPA.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 96%

Interaction between hippocampal serotonin and cannabinoid systems in reactivity to spatial and object novelty detection

Nasehi

Rostam-Nezhad

Ebrahimi-Ghiri

et al. 2017

Behavioural Brain Research

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“…As mentioned in the Introduction section, we should emphasize that we consider our modification based on the observed amygdala and prefrontal cortex nonlinear interactions [ 13 – 19 ], as well as the specific functions of both brain’s part [ 9 – 12 ]. Similar nonlinear interactions can also be found in other physical systems, for instance, in the nonlinear optical systems with two or more different interacting modes (see, e.g., [ 25 – 27 ]).…”

Section: Modified Asano-ohya-khrennikov Quantum-like Modelmentioning

confidence: 99%

“…First, we assume that the corresponding decision-making process in a two-player game is mainly due to the cognitive-emotional interaction between the brain’s amygdala and prefrontal cortex. It has already known that the amygdala is responsible for the irrational (emotional) decision in which a fear-driven emotional decision plays a significant role [ 9 , 10 ]. On the other hand, the prefrontal cortex, which is a part of the brain’s neocortex, is likely responsible for the rational (cognitive) decision, where it has an executive function [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Modified Asano-Ohya-Khrennikov quantum-like model for decision-making process in a two-player game with nonlinear self- and cross-interaction terms of brain’s amygdala and prefrontal-cortex

2020

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In this report, we propose a modification on the Asano-Ohya-Khrennikov quantum-like decision-making process model of a two-player game by adding additional nonlinear terms to the related comparison step dynamical equation. The additions are in the form of a self-interaction and cross-interaction of the brain’s amygdala and prefrontal cortex. We show that the cross-interaction significantly determines the final decision of a player, whether it becomes a rational or an irrational choice. In contrast, the nonlinear self-interaction term provides a feedback mechanism that speeds up the corresponding decision-making process. We also suggest the form of expectation values of the overall reaction rate coefficients of those nonlinear terms by making an analogy with the original model formulation.

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“…Surgery was conducted as described previously (Nasehi et al, 2016a(Nasehi et al, , 2016c(Nasehi et al, , 2016d). Mice were anesthetized using ketamine (50 mg/kg, i.p.)…”

Section: Stereotaxic Surgerymentioning

confidence: 99%

Role of the amygdala GABA-A receptors in ACPA-induced deficits during conditioned fear learning

Nasehi

Roghani

Ebrahimi-Ghiri

et al. 2017

Brain Research Bulletin

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The basolateral amygdala (BLA) is a key structure for the emotional processing and storage of memories associated with emotional events, especially fear. On the other hand, endocannabinoids and CB1 receptors play a key role in learning and memory partly through long-term synaptic depression of GABAergic synapses in the BLA. The aim of this study was to explore the effects of GABA-A receptor agonist and antagonist in the fear-related memory acquisition deficits induced by ACPA (a selective CB1 cannabinoid receptor agonist). This study used context and tone fear conditioning paradigms to assess fear-related memory in male NMRI mice. Our results showed that the pre-training intraperitoneal administration of ACPA (0.5mg/kg) or (0.1 and 0.5mg/kg) decreased the percentage of freezing time in the contextual and tone fear conditioning, respectively. This indicated an impaired context- or tone-dependent fear memory acquisition. Moreover, the pre-training intra-BLA microinjection of GABA-A receptor agonist, muscimol, at 0.05 and 0.5μg/mouse impaired context-dependent fear memory, while the same doses of GABA-A antagonist, bicuculline, impaired tone-dependent fear memory. However, a subthreshold dose of muscimol or bicuculline increased the effect of ACPA at 0.1 and 0.5 or 0.05mg/kg on context- or tone-dependent fear memory, respectively. In addition, bicuculline at the lower dose increased the ACPA response on locomotor activity compared to its respective group. Such findings highlighted an interaction between BLA GABAergic and cannabinoidergic systems during the acquisition phase of conditioned fear memories.

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Interplay between serotonin and cannabinoid function in the amygdala in fear conditioning

Cited by 12 publications

References 49 publications

Interaction between hippocampal serotonin and cannabinoid systems in reactivity to spatial and object novelty detection

Interaction between hippocampal serotonin and cannabinoid systems in reactivity to spatial and object novelty detection

Modified Asano-Ohya-Khrennikov quantum-like model for decision-making process in a two-player game with nonlinear self- and cross-interaction terms of brain’s amygdala and prefrontal-cortex

Role of the amygdala GABA-A receptors in ACPA-induced deficits during conditioned fear learning

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