Interplay Between Reactive Oxygen/Reactive Nitrogen Species and Metabolism in Vascular Biology and Disease

Ushio‐Fukai, Masuko; Ash, Dipankar; Nagarkoti, Sheela; Chantemèle, Eric J. Belin de; Fulton, David; Fukai, Tohru

doi:10.1089/ars.2020.8161

Cited by 42 publications

(32 citation statements)

References 401 publications

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“…The formation and elimination of ROS are precisely controlled by the antioxidative system. "Increased oxidative stress" or "redox control failure" is involved in the progress of many kinds of human diseases [74].…”

Section: Oxidative Stress and Oxidative Stress Biomarkersmentioning

confidence: 99%

Reactive Oxygen Species and Antioxidative Defense in Chronic Obstructive Pulmonary Disease

et al. 2021

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The respiratory system is continuously exposed to endogenous and exogenous oxidants. Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation of the airways, leading to the destruction of lung parenchyma (emphysema) and declining pulmonary function. It is increasingly obvious that reactive oxygen species (ROS) and reactive nitrogen species (RNS) contribute to the progression and amplification of the inflammatory responses related to this disease. First, we described the association between cigarette smoking, the most representative exogenous oxidant, and COPD and then presented the multiple pathophysiological aspects of ROS and antioxidative defense systems in the development and progression of COPD. Second, the relationship between nitric oxide system (endothelial) dysfunction and oxidative stress has been discussed. Third, we have provided data on the use of these biomarkers in the pathogenetic mechanisms involved in COPD and its progression and presented an overview of oxidative stress biomarkers having clinical applications in respiratory medicine, including those in exhaled breath, as per recent observations. Finally, we explained the findings of recent clinical and experimental studies evaluating the efficacy of antioxidative interventions for COPD. Future breakthroughs in antioxidative therapy may provide a promising therapeutic strategy for the prevention and treatment of COPD.

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Section: Oxidative Stress and Oxidative Stress Biomarkersmentioning

confidence: 99%

Reactive Oxygen Species and Antioxidative Defense in Chronic Obstructive Pulmonary Disease

et al. 2021

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“…Peroxynitrite was demonstrated to activate the p38 and Jun N-terminal kinases (JNK) and extracellular signal-regulated kinases (ERK) 1/2 in a wide variety of cell types. Consequently, the expression of stress genes such as c-fos and heme oxygenase-1 is also induced [ 27 , 28 ]. ERK activation by peroxynitrite in human neutrophils leads to the expression of CD11b/CD18 and to the enhanced adhesion of peroxynitrite-treated leukocytes to lipopolysaccharide-treated endothelial cells [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

“…Consequently, the expression of stress genes such as c-fos and heme oxygenase-1 is also induced [ 27 , 28 ]. ERK activation by peroxynitrite in human neutrophils leads to the expression of CD11b/CD18 and to the enhanced adhesion of peroxynitrite-treated leukocytes to lipopolysaccharide-treated endothelial cells [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

“…For example, the reduction of superoxide dismutase (SOD) activity can reduce the removal of superoxide anions and produce H 2 O 2 . The same peroxynitrite pathway can alter the catalase activity, thus lowering the cell’s capacity to remove H 2 O 2 , perhaps prolonging the ROS-mediated signaling [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

“…The reaction will also remove NO during further signaling. GSNO can act also as a donor of NO, and it has been suggested that GSNO can mediate some NO effects [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

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Nitric Oxide Interaction with the Eye

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Nitric oxide (NO) is acknowledged as a vital intercellular messenger in multiple systems in the body. Medicine has focused on its functions and therapeutic applications for decades, especially in cardiovascular and nervous systems, and its role in immunological responses. This review was composed to demonstrate the prevalence of NO in components of the ocular system, including corneal cells and multiple cells in the retina. It discussed NO’s assistance during the immune, inflammation and wound-healing processes. NO is identified as a vascular endothelial relaxant that can alter the choroidal blood flow and prompt or suppress vascular changes in age-related macular degeneration and diabetes, as well as the blood supply to the optic nerve, possibly influencing the progression of glaucoma. It will provide a deeper understanding of the role of NO in ocular homeostasis, the delicate balance between overproduction or underproduction and the effect on the processes from aqueous outflow and subsequent intraocular pressure to axial elongation and the development of myopia. This review also recognized the research and investigation of therapies being developed to target the NO complex and treat various ocular diseases.

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Oncogenic Virus-Induced Oxidative Stress and Epigenetic Regulation: An Insight into Host DNA Methylation

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Mondal

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et al. 2022

Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

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Interplay Between Reactive Oxygen/Reactive Nitrogen Species and Metabolism in Vascular Biology and Disease

Cited by 42 publications

References 401 publications

Reactive Oxygen Species and Antioxidative Defense in Chronic Obstructive Pulmonary Disease

Reactive Oxygen Species and Antioxidative Defense in Chronic Obstructive Pulmonary Disease

Nitric Oxide Interaction with the Eye

Oncogenic Virus-Induced Oxidative Stress and Epigenetic Regulation: An Insight into Host DNA Methylation

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