Interplay between platelets and coagulation

Sang, Yaqiu; Roest, Mark; Laat, Bas de; Groot, Philip G. de; Huskens, Dana

doi:10.1016/j.blre.2020.100733

Cited by 201 publications

(176 citation statements)

References 224 publications

(244 reference statements)

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“…Platelet recruitment to the venous thrombus depends on the interaction between GPIbα and exposed VWF. 11 How then, would platelets contribute to thrombosis in MPNs?…”

Section: Discussionmentioning

confidence: 99%

Glanzmann thrombasthenia complicated by frequent myeloproliferative neoplasm‐related thromboembolism: thrombosis occurring regardless of αIIbβIII integrin deficiency

Schutgens

Urbanus

2021

Clinical Case Reports

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“…Platelet recruitment to the venous thrombus depends on the interaction between GPIbα and exposed VWF. 11 How then, would platelets contribute to thrombosis in MPNs?…”

Section: Discussionmentioning

confidence: 99%

Glanzmann thrombasthenia complicated by frequent myeloproliferative neoplasm‐related thromboembolism: thrombosis occurring regardless of αIIbβIII integrin deficiency

Schutgens

Urbanus

2021

Clinical Case Reports

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“…Platelets possess two kinds of storage organelles, the α-granules and dense granules; the content of these granules are released to the surrounding environment upon platelet activation (56,57).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Added Value of Blood Cells in Thrombin Generation Testing

et al. 2021

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The capacity of blood to form thrombin is a critical determinant of coagulability. Plasma thrombin generation (TG), a test that probes the capacity of plasma to form thrombin, has improved our knowledge of the coagulation system and shows promising utility in coagulation management. Although plasma TG gives comprehensive insights in the function of pro- and anticoagulation drivers, it does not measure the role of blood cells in TG. In this literature review, we discuss currently available continuous TG tests that can reflect the involvement of blood cells in coagulation, in particular the fluorogenic assays that allow continuous measurement in platelet rich plasma and whole blood. We also provide an overview about the influence of blood cells on blood coagulation, with emphasis on the direct influence of blood cells on TG. Platelets accelerate the initiation and velocity of thrombin generation by phosphatidylserine exposure, granule content release and surface receptor interaction with coagulation proteins. Erythrocytes are also major providers of phosphatidylserine and erythrocyte membranes trigger contact activation. Furthermore, leukocytes and cancer cells may be important players in cell-mediated coagulation, because under certain conditions, they express tissue factor, release procoagulant components and can induce platelet activation. We argue that testing TG in the presence of blood cells may be useful to distinguish blood cells-related coagulation disorders. However, it should also be noted that these blood cells-dependent TG assays are not clinically validated. Further standardization and validation studies are needed to explore their clinical usefulness.

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“…Finally, exposed damaged tissue releases tissue factor that will stimulate thrombin formation. Thrombin cleaves and stimulates PAR (protease-activated receptor, in humans 1 and 4; in mice 3 and 4) on platelets and cleaves fibrinogen into fibrin that will further strengthen aggregates [ 20 ]. The clot’s final stabilization is mediated via actin–myosin platelet retraction as part of secondary hemostasis.…”

Section: Platelets Biology and Functionsmentioning

confidence: 99%

Proteomics: A Tool to Study Platelet Function

Shevchuk

Begonja

Gambaryan

et al. 2021

IJMS

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Platelets are components of the blood that are highly reactive, and they quickly respond to multiple physiological and pathophysiological processes. In the last decade, it became clear that platelets are the key components of circulation, linking hemostasis, innate, and acquired immunity. Protein composition, localization, and activity are crucial for platelet function and regulation. The current state of mass spectrometry-based proteomics has tremendous potential to identify and quantify thousands of proteins from a minimal amount of material, unravel multiple post-translational modifications, and monitor platelet activity during drug treatments. This review focuses on the role of proteomics in understanding the molecular basics of the classical and newly emerging functions of platelets. including the recently described role of platelets in immunology and the development of COVID-19.The state-of-the-art proteomic technologies and their application in studying platelet biogenesis, signaling, and storage are described, and the potential of newly appeared trapped ion mobility spectrometry (TIMS) is highlighted. Additionally, implementing proteomic methods in platelet transfusion medicine, and as a diagnostic and prognostic tool, is discussed.

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Interplay between platelets and coagulation

Cited by 201 publications

References 224 publications

Glanzmann thrombasthenia complicated by frequent myeloproliferative neoplasm‐related thromboembolism: thrombosis occurring regardless of αIIbβIII integrin deficiency

Glanzmann thrombasthenia complicated by frequent myeloproliferative neoplasm‐related thromboembolism: thrombosis occurring regardless of αIIbβIII integrin deficiency

Added Value of Blood Cells in Thrombin Generation Testing

Proteomics: A Tool to Study Platelet Function

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