Interplay Between MicroRNAs and Oxidative Stress in Ovarian Conditions with a Focus on Ovarian Cancer and Endometriosis

Marí-Alexandre, Josep; Carcelén, Antonio Pellín; Agababyan, Cristina; Moreno‐Manuel, Andrea; García-Oms, Javier; Calabuig‐Fariñas, Silvia; Gilabert-Estellés, Juan

doi:10.3390/ijms20215322

Cited by 39 publications

(23 citation statements)

References 159 publications

(182 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Brucella, Chlamydia, and Mycoplasma have been detected in over 60% of samples from those with EOC, and it is thought that the microbial dysbiosis may contribute to development of atypical epithelial cells showing hyperplasia and cytological atypia. These changes, along with genetic mutations in the ovaries gradually progress to EOC cells, particularly endometrioid and clear cell types (44)(45)(46). Figure 1 illustrates the potential carcinogenic mechanisms involved in the development of EOVC.…”

Section: Microbial Communities In Female Reproductive Tractmentioning

confidence: 99%

A Review of the Clinical Characteristics and Novel Molecular Subtypes of Endometrioid Ovarian Cancer

Chen

Qian

et al. 2021

Front. Oncol.

View full text Add to dashboard Cite

Ovarian cancer is one of the most common gynecologic cancers that has the highest mortality rate. Endometrioid ovarian cancer, a distinct subtype of epithelial ovarian cancer, is associated with endometriosis and Lynch syndrome, and is often accompanied by synchronous endometrial carcinoma. In recent years, dysbiosis of the microbiota within the female reproductive tract has been suggested to be involved in the pathogenesis of endometrial cancer and ovarian cancer, with some specific pathogens exhibiting oncogenic having been found to contribute to cancer development. It has been shown that dysregulation of the microenvironment and accumulation of mutations are stimulatory factors in the progression of endometrioid ovarian carcinoma. This would be a potential therapeutic target in the future. Simultaneously, multiple studies have demonstrated the role of four molecular subtypes of endometrioid ovarian cancer, which are of particular importance in the prediction of prognosis. This literature review aims to compile the potential mechanisms of endometrioid ovarian cancer, molecular characteristics, and molecular pathological types that could potentially play a role in the prediction of prognosis, and the novel therapeutic strategies, providing some guidance for the stratified management of ovarian cancer.

show abstract

Section: Microbial Communities In Female Reproductive Tractmentioning

confidence: 99%

A Review of the Clinical Characteristics and Novel Molecular Subtypes of Endometrioid Ovarian Cancer

Chen

Qian

et al. 2021

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…Endometriosis is a disease characterized by ectopic growth of endometrial tissue, resulting in pain symptoms and reduced fertility in affected patients [ 100 ]. MicroRNA expression is dysregulated in endometriosis and has been functionally linked to invasive growth, aberrant proliferation and stem cell function [ 101 , 102 , 103 , 104 ]. MicroRNA let-7d-3p is significantly downregulated in women with endometriosis [ 105 ].…”

Section: Let-7d In Endometriosismentioning

confidence: 99%

The Role of microRNA Let-7d in Female Malignancies and Diseases of the Female Reproductive Tract

Santis¹,

Götte²

2021

IJMS

View full text Add to dashboard Cite

microRNAs are small noncoding RNAs that regulate gene expression at the posttranscriptional level. Let-7d is a microRNA of the conserved let-7 family that is dysregulated in female malignancies including breast cancer, ovarian cancer, endometrial cancer, and cervical cancer. Moreover, a dysregulation is observed in endometriosis and pregnancy-associated diseases such as preeclampsia and fetal growth restriction. Let-7d expression is regulated by cytokines and steroids, involving transcriptional regulation by OCT4, MYC and p53, as well as posttranscriptional regulation via LIN28 and ADAR. By downregulating a wide range of relevant mRNA targets, let-7d affects cellular processes that drive disease progression such as cell proliferation, apoptosis (resistance), angiogenesis and immune cell function. In an oncological context, let-7d has a tumor-suppressive function, although some of its functions are context-dependent. Notably, its expression is associated with improved therapeutic responses to chemotherapy in breast and ovarian cancer. Studies in mouse models have furthermore revealed important roles in uterine development and function, with implications for obstetric diseases. Apart from a possible utility as a diagnostic blood-based biomarker, pharmacological modulation of let-7d emerges as a promising therapeutic concept in a variety of female disease conditions.

show abstract

“…However, there has been no data on whether EAOC has a strong ability to resist oxidative stress, and there is no evidence to support this hypothesis. In addition, it has recently been reported that the interaction between oxidative stress and non-coding microRNAs has an important role in the development of EAOC [ 19 ], but further study is required.…”

Section: Endometriosis and Eaocmentioning

confidence: 99%

Endometriosis-Associated Ovarian Cancer: The Origin and Targeted Therapy

Murakami

Kotani

Nakai

et al. 2020

Cancers

View full text Add to dashboard Cite

Endometrial cysts (ECs) are thought to be the origin of endometriosis-associated ovarian cancer (EAOC). A hypothesis that the oxidative stress of iron in cysts causes “malignant transformation of ECs” has been proposed, but this has not been verified. Several population-based studies showed that endometriosis was a risk factor but did not reflect the “malignant transformation of ECs”. A review showed that most patients were diagnosed with EAOC early in monitoring following detection of ECs, and that these cases might have been cancer from the start. Epidemiologically, EAOC was reduced by hysterectomy rather than by cystectomy of ECs. Gene mutation analyses identified oncogenic mutations in endometriosis and normal endometrium and revealed that the same mutations were present at different endometriotic lesions. It was also shown that most of the gene mutations found in endometriosis occurred in normal endometrium. Taking together, EAOC might be caused by eutopic endometrial glandular epithelial cells with oncogenic mutations that have undergone menstrual blood reflux and engrafted in the ovary, rather than by low-risk ECs acquiring oncogenic mutations and becoming malignant. This review discusses the mechanisms of EAOC development and targeted therapy based on genetic variation in EAOC with a focus on eutopic endometrium.

show abstract

Interplay Between MicroRNAs and Oxidative Stress in Ovarian Conditions with a Focus on Ovarian Cancer and Endometriosis

Cited by 39 publications

References 159 publications

A Review of the Clinical Characteristics and Novel Molecular Subtypes of Endometrioid Ovarian Cancer

A Review of the Clinical Characteristics and Novel Molecular Subtypes of Endometrioid Ovarian Cancer

The Role of microRNA Let-7d in Female Malignancies and Diseases of the Female Reproductive Tract

Endometriosis-Associated Ovarian Cancer: The Origin and Targeted Therapy

Contact Info

Product

Resources

About