Interplay between materials and microfluidics

Hou, Xu; Zhang, Yu Shrike; Santiago, Grissel Trujillo‐de; Álvarez, Mario Moisés; Ribas, João Francisco Magno; Jonas, Steven J.; Weiss, Paul S.; Andrews, Anne M.; Aizenberg, Joanna; Khademhosseini, Ali

doi:10.1038/natrevmats.2017.16

Cited by 284 publications

(239 citation statements)

References 178 publications

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“…[60,67,68] This will result in a controllable liquid flow on the surface, showing wide applications in mechanical engineering, including in controllable self-lubrication (Figure 4c), and heat or mass transfer. [69] In addition, one of the important applications of peristome-mimetic structures could be in microfluidics, [70] and the unidirectional liquid transport on the biomimetic structure in channels could be used for smart and controllable microfluidic devices (Figure 4d), for example, the lab-on-a-chip. The developed preparation and control method have constructed the platform for further research in applications, and its huge potential should be delivered in the near future.…”

Section: Applications Of Peristome-inspired Surfacesmentioning

confidence: 99%

Surfaces Inspired by the Nepenthes Peristome for Unidirectional Liquid Transport

et al. 2017

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The slippery peristome of the pitcher plant Nepenthes has attracted much attention due to its unique function for preying on insects. Recent findings on the peristome surface of Nepenthes alata demonstrate a fast and continuous unidirectional liquid transport, which is enabled by the combination of a pinning effect at the sharp edges and a capillary rise in the wedge, deriving from the multiscale structure, which provides inspiration for designing and fabricating functional surfaces for unidirectional liquid transport. Developments in the fabrication methods of peristome‐inspired surfaces and control methods for liquid transport are summarized. Both potential applications in the fields of microfluidic devices, biomedicine, and mechanical engineering and directions for further research in the future are discussed.

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Section: Applications Of Peristome-inspired Surfacesmentioning

confidence: 99%

Surfaces Inspired by the Nepenthes Peristome for Unidirectional Liquid Transport

et al. 2017

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“…The microfluidic technology has a variety of advantages over traditional methods for particle synthesis. This technology allows better control over the nanoparticle sizes and properties as a result of efficient mixing and rapid mass transfer at the microscale …”

Section: Introductionmentioning

confidence: 99%

Fabrication of Thymoquinone‐Loaded Albumin Nanoparticles by Microfluidic Particle Synthesis and Their Effect on Planarian Regeneration

Kazan

Yeşil-Çeliktaş

Zhang

2019

Macromolecular Bioscience

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Thymoquinone is the main bioactive component of the plant Nigella sativa, which is commonly known as black seeds and has several therapeutic effects. However, clinical applications of thymoquinone are limited due to its hydrophobic nature. In this study, thymoquinone is encapsulated in albumin nanoparticles by using a microfluidic platform to overcome this limitation. The mean particle sizes of empty and thymoquinone‐loaded nanoparticles are determined as 271.3 and 315.6 nm, respectively, with polydispersity index values both lower than 0.25. In addition to particle size distribution measurements, characterizations of the prepared nanoparticles such as zeta potential measurements, in vitro release studies, as well as scanning electron microscopy, Fourier‐transform infrared, and differential scanning calorimetry analyses are also carried out. To determine the effect of thymoquinone on neural regeneration, planarians are used as the model organism. After application of free and encapsulated thymoquinone, planarians are amputated and the fragments are observed in terms of head and tail regeneration, swimming pattern, and behavior. The results indicate that thymoquinone affects their behavior and primarily enhances head regeneration of planarians. In addition, it is shown that encapsulation of thymoquinone not only enhances the thermal stability of the molecule but also decreases its toxicity.

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“…[1][2][3][4][5][6] As a core element of microfluidic technology, high-performance fabrication of hollow microchannels with freeform geometries is crucial for further developing innovative microfluidic technology. [12][13][14] Currently, one of the most representative 3D microfabrication techniques of fused silica is ultrashort pulse laser microfabrication. [7][8][9][10][11] Fused silica is one of the widely used substrates for the microfluidic technology in laboratory research and industrial applications due to its high melting point, high chemical stability, low thermal expansion coefficient, wide transmission spectral range, and good biocompatibility.…”

mentioning

confidence: 99%

Freeform Microfluidic Networks Encapsulated in Laser‐Printed 3D Macroscale Glass Objects

Lin

Song

et al. 2020

Adv Materials Technologies

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and fine chemical industries. [1][2][3][4][5][6] As a core element of microfluidic technology, high-performance fabrication of hollow microchannels with freeform geometries is crucial for further developing innovative microfluidic technology. In particular, extension of the microfluidic networks from widely used 2D to 3D configurations has now been considered as a promising scheme to enhance the performance of manipulation of fluids such as high-efficiency mixing, separation, and detection. [7][8][9][10][11] Fused silica is one of the widely used substrates for the microfluidic technology in laboratory research and industrial applications due to its high melting point, high chemical stability, low thermal expansion coefficient, wide transmission spectral range, and good biocompatibility. However, fabrication of freeform 3D hollow microchannels in fused silica is still difficult for current 2D fabrication techniques in terms of complex and tedious fabrication procedures, additional costs for aligning, stacking, and bonding steps. [12][13][14] Currently, one of the most representative 3D microfabrication techniques of fused silica is ultrashort pulse laser microfabrication. [15][16][17][18][19][20] A suspended hollow microchannel structure with a 3D controllable configuration can be fabricated in a way of either laser-assisted selective wet etching [21][22][23] or liquid-assisted laser ablation. [24][25][26] In addition, suspended hollow structures with 3D shapes and a high precision in fused silica can be fabricated by combining room-temperature casting and sacrificial template replication. [27] Meanwhile, 3D printing of glass materials emerging in recent years brings some new opportunities for scalable fabrication of freeform glass structures by either additive manufacturing strategies [28][29][30][31][32][33] or laser subtractive processing methods. [34][35][36] However, controllable formation of freeform hollow microchannel with arbitrary length encapsulated in 3D printed glass structures has not yet been demonstrated, which is highly desirable for high-infidelity manufacturing of artificial organs, on-chip construction of biomimetic microenvironments, [37][38][39][40][41] as well as enrichment of the functions of continuous-flow microreactors (e.g., seamless integration of customized functional module for temperature control and on-line spectrometer monitoring). [42,43] Especially, simultaneous fabrication of 3D embedded hollow microchannels with high aspect ratios and centimeter-scale glass objects with external arbitrary shapes on/in a single substrate still Large-scale microfluidic microsystems with complex 3D configurations are highly in demand by both fundamental research and industrial application, holding the potentials for fostering a wide range of innovative applications such as organ-on-a-chip as well as continuous-flow manufacturing. However, freeform fabrication of such systems remains challenging for current fabrication techniques in terms of fabrication resolution, flexibility, and achievable foo...

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Interplay between materials and microfluidics

Cited by 284 publications

References 178 publications

Surfaces Inspired by the Nepenthes Peristome for Unidirectional Liquid Transport

Surfaces Inspired by the Nepenthes Peristome for Unidirectional Liquid Transport

Fabrication of Thymoquinone‐Loaded Albumin Nanoparticles by Microfluidic Particle Synthesis and Their Effect on Planarian Regeneration

Freeform Microfluidic Networks Encapsulated in Laser‐Printed 3D Macroscale Glass Objects

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