Interplay betweenPitx2andPax7temporally governs specification of extraocular muscle progenitors
Mao Kuriki,
Glenda Comai,
Shahragim Tajbakhsh
Abstract:Gene regulatory networks that act upstream of skeletal muscle fate determinants are distinct in different anatomical locations. Despite recent efforts, a clear understanding of the cascade of events underlying the emergence and maintenance of the stem cell pool in specific muscle groups remains unresolved and debated. Here, we invalidated Pitx2 with multiple Cre-driver mice prenatally, postnatally, and during lineage progression and showed that this gene becomes progressively dispensable for specification and … Show more
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