Interplay between Humoral and CLA+ T Cell Response against Candida albicans in Psoriasis

Jesús‐Gil, Carmen de; Nicolàs, Lídia Sans-de San; Ruiz-Romeu, Ester; Ferrán, Marta; Soria-Martinez, Laura; García-Jiménez, Irene; Chiriac, Anca; Casanova-Seuma, J.M.; Fernández‐Armenteros, Josep Manel; Owens, Sherry; Howell, Michael D.; Pujol, Ramón M.; Santamaria‐Babí, Luis F.

doi:10.3390/ijms22041519

Cited by 10 publications

(11 citation statements)

References 54 publications

(25 reference statements)

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“…These results suggest that increased exposure to S. pyogenes, as demonstrated by the presence of specific humoral immune response even in patients with ASO negative, upon recognition by CLA + T cells can fuel pathogenic IL-17 production. Remarkably, similar association has been recently described for Candida albicans, which is a potent IL-23/Th17 inducer too (17). Some other new mechanisms in PSO relating CLA + T cells and IL-17 have been recently revealed.…”

Section: Psoriasissupporting

confidence: 73%

The Translational Relevance of Human Circulating Memory Cutaneous Lymphocyte-Associated Antigen Positive T Cells in Inflammatory Skin Disorders

et al. 2021

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Circulating memory T cells are heterogeneous in their tissue tropism. The skin-seeking T cell subset expresses the cutaneous lymphocyte-associated antigen (CLA) on their surface. CLA+ memory T cells not only migrate from blood to skin but also recirculate between blood and skin. Studying CLA+ memory T cells in cutaneous diseases has allowed a better understanding of immune-inflammatory mechanisms that take place. The analysis of the phenotypical features of these cells, their antigen specificity, cytokine production profile, and changes in relationship to clinical status and therapies among other characteristics have led to the concept that they constitute peripheral cellular biomarkers in T cell-mediated cutaneous conditions. CLA+ memory T cells are of relevance in the pathogenesis of several cutaneous diseases, such as psoriasis (PSO), atopic dermatitis, vitiligo, and drug-induced allergic reactions, to name a few. The interaction of circulating CLA+ T cells with skin-resident cells has been investigated in different ex vivo coculture models made out of clinical samples. Interestingly, microbes that are present in the skin or related with human skin diseases are preferentially recognized by CLA+ T cells. Thus, the interaction of Streptococcus pyogenes with CLA+ T cells in PSO is providing novel concepts that help to understand disease immunopathogenesis. The goal of this review is to present latest results in the field of CLA+ T cells in T cell-mediated inflammatory skin diseases and their translational relevance for human immunodermatology.

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Section: Psoriasissupporting

confidence: 73%

The Translational Relevance of Human Circulating Memory Cutaneous Lymphocyte-Associated Antigen Positive T Cells in Inflammatory Skin Disorders

et al. 2021

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“…However, these findings may be a result of confounders or from psoriasis patients being more susceptible to infection. H. pylori may potentiate psoriasis by inducing CD4+ T cell responses [ 222 ], while C. Albicans elicits antibody and Th17 responses [ 223 ]. Patients with treated H. pylori also have a lower severity of psoriasis than untreated individuals, further highlighting their association [ 222 ].…”

Section: Contributors To Barrier Dysregulation In Psoriasismentioning

confidence: 99%

Skin Barrier Dysregulation in Psoriasis

Andreas

Bereza-Malcolm

Lynch

et al. 2021

IJMS

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The skin barrier is broadly composed of two elements—a physical barrier mostly localised in the epidermis, and an immune barrier localised in both the dermis and epidermis. These two systems interact cooperatively to maintain skin homeostasis and overall human health. However, if dysregulated, several skin diseases may arise. Psoriasis is one of the most prevalent skin diseases associated with disrupted barrier function. It is characterised by the formation of psoriatic lesions, the aberrant differentiation and proliferation of keratinocytes, and excessive inflammation. In this review, we summarize recent discoveries in disease pathogenesis, including the contribution of keratinocytes, immune cells, genetic and environmental factors, and how they advance current and future treatments.

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“…From our experience, circulating CLA + memory T cells activated with a relevant disease trigger, such as Streptococcus pyogenes, and in the presence of lesional epidermal cells, secrete a higher amount of IL-17F than IL-17A in vitro (28,29). Similarly, increased CLA + memory T cell-dependent IL-17F response was observed when stimulating the cocultures with Candida albicans (30) or the combination of the pro-inflammatory cytokines IL-15 and IL-23 (23). As such, CLA + memory T cells should be considered an important source of IL-17F in psoriasis.…”

Section: Cla + T Cells In Psoriasis Produce More Il-17f Than Il-17amentioning

confidence: 68%

Human CLA+ Memory T Cell and Cytokines in Psoriasis

et al. 2021

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Psoriasis is a common inflammatory skin condition resulting from the interplay between epidermal keratinocytes and immunological cellular components. This sustained inflammation is essentially driven by pro-inflammatory cytokines with the IL-23/IL-17 axis playing a critical central role, as proved by the clinical efficacy of their blockade in patients. Among all the CD45R0+ memory T cell subsets, those with special tropism for cutaneous tissues are identified by the expression of the Cutaneous Lymphocyte-associated Antigen (CLA) carbohydrate on their surface, that is induced during T cell maturation particularly in the skin-draining lymph nodes. Because of their ability to recirculate between the skin and blood, circulating CLA+ memory T cells reflect the immune abnormalities found in different human cutaneous conditions, such as psoriasis. Based on this premise, studying the effect of different environmental microbial triggers and psoriatic lesional cytokines on CLA+ memory T cells, in the presence of autologous epidermal cells from patients, revealed important IL-17 cytokines responses that are likely to enhance the pro-inflammatory loop underlying the development of psoriatic lesions. The goal of this mini-review is to present latest data regarding cytokines implicated in plaque and guttate psoriasis immunopathogenesis from the prism of CLA+ memory T cells, that are specifically related to the cutaneous immune system.

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Interplay between Humoral and CLA+ T Cell Response against Candida albicans in Psoriasis

Cited by 10 publications

References 54 publications

The Translational Relevance of Human Circulating Memory Cutaneous Lymphocyte-Associated Antigen Positive T Cells in Inflammatory Skin Disorders

The Translational Relevance of Human Circulating Memory Cutaneous Lymphocyte-Associated Antigen Positive T Cells in Inflammatory Skin Disorders

Skin Barrier Dysregulation in Psoriasis

Human CLA+ Memory T Cell and Cytokines in Psoriasis

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