Interplay between Experimental Dental Pellicles and Stannous-Containing Toothpaste on Dental Erosion-Abrasion

Hara, Anderson T.; Lippert, Frank; Zero, Domenick T.

doi:10.1159/000347051

Cited by 37 publications

(32 citation statements)

References 51 publications

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“…Thus, the present study included a series of experiments that tested the effects of 3 different formulations and a placebo under changing erosive conditions using 1 type of acid. Citric acid was used because it is often the demineralisation agent in erosion or erosion/abrasion studies; ranges of concentrations and pH values were chosen according to the literature (for example Lagerweij et al [2006]; Attin et al [2007]; Hara et al [2009]; Ganss et al [2012]; Hara et al [2013]). The other parameters (erosion time, brushing time, brushing force and remineralisation procedure) were kept constant and followed our previous experiments [Ganss et al, , 2012 as well as recommendations for erosion and erosion/abrasion studies [Wiegand and Attin, 2011;Shellis et al, 2011].…”

Section: Discussionmentioning

confidence: 99%

Effects of Erosion Protocol Design on Erosion/Abrasion Study Outcome and on Active Agent (NaF and SnF2) Efficacy

et al. 2016

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There is no standard for testing anti-erosive/anti-abrasive agents, making the assessment and comparison of study results difficult. Factors which are varied in study designs are amongst others the erosive medium regarding concentration and pH or movement type of acid. The present study therefore investigated the impact of these factors on dimension of tissue loss and on efficacy of active agents used as anti-erosive/anti-abrasive therapeutics. In 8 experiments, consisting of 8 groups each (n = 20 each), resulting in a total of 64 groups, enamel specimens were demineralised (10 days, 6 × 2 min/day) using different acids (1, 0.5 and 0.3% citric acid at native pH 2.3, 2.5 and 2.8, respectively, and 0.3% citric acid adjusted to pH 3.6) with two different movement types (jerky or smooth). Specimens were immersed (2 × 2 min/day) in slurries of 1,450 ppm F^- toothpaste (NaF), 1,450 ppm F^- and 3,436 ppm Sn²⁺ toothpaste (NaF/SnF₂), 970 ppm F^- and 3,000 ppm Sn²⁺ gel (SnF₂) or placebo, or were additionally brushed during immersion (15 s, 200 g). All groups were in between stored in a mineral salt solution. Tissue loss was determined profilometrically. Movement type, pH and concentration of acid had a substantial impact on study outcome. The combination of jerky movement and concentrated acid masked, to some extent, differences between erosive and erosive-abrasive tissue loss. The acid at low concentration (0.3%), independent of pH, was too mild to produce any tissue loss. The model with the best ability to demonstrate effects of abrasive impacts and active agents used the 1% acid concentration combined with smooth acid movements.

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Section: Discussionmentioning

confidence: 99%

Effects of Erosion Protocol Design on Erosion/Abrasion Study Outcome and on Active Agent (NaF and SnF2) Efficacy

et al. 2016

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“…Regarding the tin fluoride, one study showed that natural pellicle formed in situ did not result in any negative influence on its protective effect [Hove et al, 2008]. Also, when the pellicle was simulated in an in vitro study significantly less erosive wear for Sn-containing toothpastes was observed [Hara et al, 2013]. Regarding the CO 2 laser irradiation, it is also probable that it would not negatively influence the effects, since pellicles have a high protein content (proteins, peptides, lipids, and other macromolecules) and these components show a very poor absorption at 10.6 μm, being almost transparent Zuerlein et al, 1999].…”

Section: Discussionmentioning

confidence: 99%

Combined Tin-Containing Fluoride Solution and CO2 Laser Treatment Reduces Enamel Erosion in vitro

Esteves‐Oliveira

Witulski

Hilgers³

et al. 2015

Caries Res

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The aim of this in vitro study was to evaluate the effect of combined CO₂ laser and tin-containing fluoride treatment on the formation and progression of enamel erosive lesions. Ninety-six human enamel samples were obtained, stored in thymol solution and, after surface polishing, randomly divided into 6 different surface treatment groups (n = 16 in each group) as follows: no treatment, control (C); one CO₂ laser irradiation (L1); two CO₂ laser irradiations (L2); daily application of fluoride solution (F); combined daily fluoride solution + one CO₂ laser irradiation (L1F), and combined daily fluoride solution + two CO₂ laser irradiations (L2F). Laser irradiation was performed at 0.3 J/cm² (5 µs/226 Hz/10.6 µm) on day 1 (L1) and day 6 (L2). The fluoride solution contained AmF/NaF (500 ppm F), and SnCl₂ (800 ppm Sn) at pH 4.5. After surface treatment the samples were submitted to an erosive cycling over 10 days, including immersion in citric acid (2 min/0.05 M/pH = 2.3) 6 times daily and storage in remineralization solution (≥1 h) between erosive attacks. At the end of each cycling day, the enamel surface loss (micrometers) was measured using a 3D laser profilometer. Data were statistically analyzed by means of a 2-level mixed effects model and linear contrasts (α = 0.05). Group F (-3.3 ± 2.0 µm) showed significantly lower enamel surface loss than groups C (-27.22 ± 4.1 µm), L1 (-18.3 ± 4.4 µm) and L2 (-16.3 ± 5.3 µm) but higher than L1F (-1.0 ± 4.4 µm) and L2F (1.4 ± 3.2 µm, p < 0.05). Under the conditions of this in vitro study, the tin-containing fluoride solution caused 88% reduction of enamel surface loss, while its combination with CO₂ laser irradiation at 0.3 J/cm² hampered erosive loss almost completely.

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“…titanium tetrafluoride or stannous fluoride, were shown to be of higher efficacy. 3,4 In the last years, numerous toothpastes with "anti-erosive" or "repairing" claims were marketed, which contain other active ingredients besides fluorides, e.g. hydroxyapatite nanoparticles, zinc-carbonate-hydroxyapatite nanoparticles, potassium nitrate, stannous salts, chitosan and/or proteins.…”

Section: Introductionmentioning

confidence: 99%

Prevention of dentine erosion by brushing with anti-erosive toothpastes

Aykut-Yetkiner

Attin

Wiegand

2014

Journal of Dentistry

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OBJECTIVE This in vitro study aimed to investigate the preventive effect of brushing with anti-erosive toothpastes compared to a conventional fluoride toothpaste on dentine erosion. MATERIALS AND METHODS Bovine dentine specimens (n=12 per subgroup) were eroded in an artificial mouth (6 days, 6×30 s/day) using either citric acid (pH:2.5) or a hydrochloric acid/pepsin solution (pH:1.6), simulating extrinsic or intrinsic erosive conditions, respectively. In between, the specimens were rinsed with artificial saliva. Twice daily, the specimens were brushed for 15 s in an automatic brushing machine at 2.5 N with a conventional fluoride toothpaste slurry (elmex, AmF) or toothpaste slurries with antierosive formulations: Apacare (NaF/1% nHAP), Biorepair (ZnCO3-HAP), Chitodent (Chitosan), elmex Erosionsschutz (NaF/AmF/SnCl2/Chitosan), mirasensitive hap (NaF/30% HAP), Sensodyne Proschmelz (NaF/KNO3). Unbrushed specimens served as control. Dentine loss was measured profilometrically and statistically analysed using two-way and one-way ANOVA followed by Scheffe's post hoc tests. RDAvalues of all toothpastes were determined, and linear mixed models were applied to analyse the influence of toothpaste abrasivity on dentine wear (p<0.05). RESULTS Dentine erosion of unbrushed specimens amounted to 5.1±1.0 m (extrinsic conditions) and 12.9±1.4 m (intrinsic conditions). All toothpastes significantly reduced dentine erosion by 24-67% (extrinsic conditions) and 21-40% (intrinsic conditions). Biorepair was least effective, while all other toothpastes were not significantly different from each other. Linear mixed models did not show a significant effect of the RDA-value of the respective toothpaste on dentine loss. CONCLUSION Toothpastes with anti-erosive formulations reduced dentine erosion, especially under simulated extrinsic erosive conditions, but were not superior to a conventional fluoride toothpaste. Materials&Methods: Bovine dentin specimens (n=12 per subgroup) were eroded in an artificial mouth (6 days, 6x30 s/day) using either citric acid (pH:2.5) or a hydrochloric acid/pepsin solution (pH:1.6), simulating extrinsic or intrinsic erosive conditions, respectively. In between, the specimens were rinsed with artificial saliva.Twice daily, the specimens were brushed for 15 s in an automatic brushing machine at 2.5N with a conventional fluoride toothpaste slurry (elmex, AmF) or toothpaste slurries with anti-erosive formulations: Apacare (NaF/1% nHAP), Biorepair (ZnCO 3 -HAP), Chitodent (Chitosan), elmex Erosionsschutz (NaF/AmF/SnCl 2 /Chitosan), mirasensitive hap (NaF/30% HAP), Sensodyne Proschmelz (NaF/KNO 3 ). Unbrushed specimens served as control. Dentin loss was measured profilometrically and statistically analysed using two-way and one-way ANOVA followed by Scheffe`s post-hoc tests. RDA-values of all toothpastes were determined, and linear mixed models were applied to analyse the influence of toothpaste abrasivity on dentin wear (p<0.05).Results: Dentin erosion of unbrushed specimens amounted to 5.1±1.0µm (extrinsi...

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Interplay between Experimental Dental Pellicles and Stannous-Containing Toothpaste on Dental Erosion-Abrasion

Cited by 37 publications

References 51 publications

Effects of Erosion Protocol Design on Erosion/Abrasion Study Outcome and on Active Agent (NaF and SnF<sub>2</sub>) Efficacy

Effects of Erosion Protocol Design on Erosion/Abrasion Study Outcome and on Active Agent (NaF and SnF<sub>2</sub>) Efficacy

Combined Tin-Containing Fluoride Solution and CO<sub>2</sub> Laser Treatment Reduces Enamel Erosion in vitro

Prevention of dentine erosion by brushing with anti-erosive toothpastes

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