Interplay between Exosomes and Autophagy in Cardiovascular Diseases: Novel Promising Target for Diagnostic and Therapeutic Application

Tian, Jinfan; Popal, Mohammad Sharif; Zhao, Yingke; Liu, Yanfei; Chen, Ke-ji; Liu, Yue

doi:10.14336/ad.2018.1020

Cited by 28 publications

(20 citation statements)

References 82 publications

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“…Release of microparticles and IL-1β from microglia downstream of sphingomyelinase activity was shown to be p38-dependent based on an inhibitor that targets p38α and p38β (Bianco et al, 2009). SB203580, the inhibitor used in this work, has been, however, shown to affect autophagy (Menon et al, 2015) and therefore may affect vesicle trafficking and release (Tian et al, 2019). Thus, studies in p38 knockout microglia are needed to clarify the role of p38 kinases.…”

Section: Microglial Functions Of P38 Kinasesmentioning

confidence: 94%

Functions of p38 MAP Kinases in the Central Nervous System

Asih

Prikas

Stefanoska

et al. 2020

Front. Mol. Neurosci.

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Mitogen-activated protein (MAP) kinases are a central component in signaling networks in a multitude of mammalian cell types. This review covers recent advances on specific functions of p38 MAP kinases in cells of the central nervous system. Unique and specific functions of the four mammalian p38 kinases are found in all major cell types in the brain. Mechanisms of p38 activation and downstream phosphorylation substrates in these different contexts are outlined and how they contribute to functions of p38 in physiological and under disease conditions. Results in different model organisms demonstrated that p38 kinases are involved in cognitive functions, including functions related to anxiety, addiction behavior, neurotoxicity, neurodegeneration, and decision making. Finally, the role of p38 kinases in psychiatric and neurological conditions and the current progress on therapeutic inhibitors targeting p38 kinases are covered and implicate p38 kinases in a multitude of CNS-related physiological and disease states.

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Section: Microglial Functions Of P38 Kinasesmentioning

confidence: 94%

Functions of p38 MAP Kinases in the Central Nervous System

Asih

Prikas

Stefanoska

et al. 2020

Front. Mol. Neurosci.

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“…Exosomes-related miRNAs (i.e. miR-19b, miR-20a/b, miR-21, miR-30a, miR-33, miR-125b, miR-130a, miR-214, miR-221/222, miRNA-223, miRNA-302a, and miR-758) have been suggested to regulate autophagy flux via modulation of PI3K-Akt-mTOR and AMPK-mTOR signaling and downstream autophagic molecules including ATG or Beclin1, P62, and ULK1; which consequently increased expression of ABCA1 and cholesterol efflux in the atherosclerosis and cardiovascular diseases [73]. It has been revealed that tumor-derived exosomes play a major role in different stages of tumor progression of all cancer types.…”

Section: Modulation Of Autophagy Via Exosome Vice Versamentioning

confidence: 99%

“…Autophagy plays pivotal role in different pathological condition such as cancer and cardiovascular diseases (CVD) ( [73] {Guo, 2013 #137)}. In tumor cells, both autophagy and exosome secretion are accelerated.…”

Section: Clinical Translation Potential Of Exosomes-mediated Autophagymentioning

confidence: 99%

Exosomal cargos modulate autophagy in recipient cells via different signaling pathways

et al. 2020

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Vesicular system of mammalian cells is composed of two intracellular and extracellular vesicles systems, which contributes to the intra/intercellular communication and cellular homeostasis. These systems mediate transferring of biological molecules like proteins, nucleic acids, and lipids inside the cytoplasm, and between the cells. By the present study, authors describe molecular crosslink between exosome biogenesis and autophagy and take a certain focus on the autophagic cargos of exosomes and signaling pathways involved in exosome-induced autophagy in target cells and vice versa. Autophagy the generation of double-phospholipid vesicles, is a process that engulfs damaged proteins and organelles, share molecular similarity and function synergy with exosomes biogenesis for degradation or exocytosis of certain cargo. Exosomes, the smallest subtype of extracellular vesicles, originating from the membrane of the multivesicular body located inside cells demonstrate key roles in the intracellular and intercellular communication. Growing evidence demonstrates the interaction between exosome biogenesis and autophagy both at intertwined molecular pathways and crossbred vesicles known as amphisomes. Crosstalk between exosome biogenesis and autophagy contributes to maintain cellular homeostasis under external and internal stresses. Moreover, these processes can modulate each other via different signaling pathways. Exosomes contain autophagic cargos that induce autophagy via the cascade of molecular events in target cells, which called here exosome-induced autophagy. Taken together, crosstalk between exosome biogenesis and autophagy plays pivotal roles in cell homeostasis. Shedding light on the interaction between endomembrane systems may promote our knowledge about the relation between exosome and autophagy pathways in lysosome-related disorders against treatments; proposing a theoretical approach for therapy.

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“…Cardiac pathology has also been found to be associated with other neurodegenerative conditions such as Huntington's disease (Critchley et al, 2018). Interestingly, it is hypothesized that factors systemically linking these pathologies are associated with neuroinflammation and oxidative stress pathways (Liu et al, 2019;Tian et al, 2019). While the underlying mechanisms in the aging heart or brain are still unclear, greater research is needed to test the potential for pharmacological interventions in these pathways.…”

Section: Editorial On the Research Topic Medicinalmentioning

confidence: 99%