Interplay between crosslinkers and dynamic molecular motor-induced instabilities in the moderation of biopolymer organization

Smith, Daniel M.; Ziebert, Falko; Humphrey, David; Duggan, C.; Zimmermann, Walter; Käs, Josef A.

doi:10.1016/s0021-9290(06)83852-2

Cited by 2 publications

(1 citation statement)

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“…Such inhomogeneities may arise from motor crowding or from large fluctuations in the concentration of ATP under condition of near depletion. Very recent experiments in purified actin-myosin II solutions have indeed suggested that the motor-driven formation of spatially inhomogeneous patterns, such as asters and vortices, may be associated with strong inhomogeneities in motor activity [30].…”

Section: Solutionsmentioning

confidence: 99%

Hydrodynamics of isotropic and liquid crystalline active polymer solutions

2006

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We describe the large-scale collective behavior of solutions of polar biofilaments and both stationary and mobile crosslinkers. Both mobile and stationary crosslinkers induce filament alignment promoting either polar or nematic order. In addition, mobile crosslinkers, such as clusters of motor proteins, exchange forces and torques among the filaments and render the homogeneous states unstable via filament bundling. We start from a Smoluchowski equation for rigid filaments in solutions, where pairwise crosslink-mediated interactions among the filaments yield translational and rotational currents. The large-scale properties of the system are described in terms of continuum equations for filament and motor densities, polarization We make contact with work by other authors and show that our model allows for an estimate of the various parameters in the hydrodynamic equations in terms of physical properties of the crosslinkers.

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Section: Solutionsmentioning

confidence: 99%