Interplay between arterial stiffness and diastolic function

Zito, Concetta; Mohammed, M.; Todaro, Maria Chiara; Khandheria, Bijoy K.; Cusmà-Piccione, Maurizio; Oreto, Giuseppe; Pugliatti, Pietro; Abusalima, Mohamed; Antonini‐Canterin, Francesco; Vriz, Olga; Carerj, Scipione

doi:10.2459/jcm.0000000000000093

Cited by 28 publications

(21 citation statements)

References 51 publications

(60 reference statements)

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“…Cesare Russo et al [18] studied gender difference in arterial stiffness and its relation to diastolic function, and found general arterial stiffness to be correlated with female gender which reflected the higher incidence of diastolic dysfunction in females. Similar results correlating general arterial stiffness-as reflected by pulse wave velocity, central pulse pressure/stroke volume index, total arterial compliance, pulse pressure amplification, and augmentation indexwith diastolic function was found by Zito et al [19], Agoşton-Coldea et al [20], and Mottram et al [21].…”

Section: Discussionsupporting

confidence: 83%

Relation Between LV Diastolic Function and Aortic Compliance as Assessed by Transthoracic Echo

Eweda¹,

Samir²,

Abdeltawab³

2017

J Cardiovasc Dis Diagn

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Arterial compliance and stiffness of the ascending aorta are important components of the elastic nature of the arterial system. Several pathological conditions are known to potentially affect arterial compliance properties as occurs with the arterial hypertension, and diabetes mellitus. Factors known to affect LV elasticity are similar to those affecting aortic elasticity.Our aim in that study is to study correlation of aortic stiffness and LV diastolic function and the factors that affect each. We scanned 254 patients presenting for routine echocardiography to Ain Shams University Hospitals Echocardiography unit; where clinical history was taken, examination and 2D echocardiography done where we indexed the elastic properties of the aorta by calculating of aortic distensibility (AD), aortic stiffness index (ASI), and pressure-strain elastic modulus (Ep), and LV diastolic function was evaluated as well.Both presence and grade of left ventricular diastolic dysfunction were significantly correlated with each of arterial hypertension and diabetes mellitus separately and presence of both hypertension and diabetes mellitus was correlated with LVDD.Aortic compliance-with its three studied elements; AS%, AD and ASI-was significantly correlated with grade of LVDD yet only elastic modulus was independently correlated with diastolic dysfunction.

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Section: Discussionsupporting

confidence: 83%

Relation Between LV Diastolic Function and Aortic Compliance as Assessed by Transthoracic Echo

Eweda¹,

Samir²,

Abdeltawab³

2017

J Cardiovasc Dis Diagn

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“…Previous studies investigated possible association of both arterial stiffness and pulse pressure with left ventricular diastolic dysfunction in hypertensive patients [32,33]. In particular, Mottram et al [32] observed an independent [18].…”

Section: Discussionmentioning

confidence: 96%

Impact of pulse pressure on left ventricular global longitudinal strain in normotensive and newly diagnosed, untreated hypertensive patients

Lembo

Esposito

Iudice

et al. 2016

Journal of Hypertension

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“…Therefore, there is an increasing interest for an extensive evaluation of stiffness parameters, particularly in patients at major risk. Recently, new radio frequency based software has been introduced, as alternative approach over conventional method, for assessing local arterial stiffness in clinical routine [9][10][11][12][13]. However, in our knowledge, studies investigating the relation between arterial stiffness, by echo-tracking systems, and plaque composition are lacking to date.…”

Section: Discussionmentioning

confidence: 99%

RANK-L is a Potential Therapeutic Target in Homogeneous Atherosclerotic Plaques

Galfo¹,

Zito²,

Caridi³

et al. 2018

J Clin Exp Cardiolog

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Objective and design: The late stages of carotid atherosclerosis are responsible for increased local stiffness, suggesting the need for a therapeutic target that affect either plaque composition and arterial stiffness. There is a lack of data on the role of the local arterial stiffness, assessed by radio-frequency based system and its relationship with the molecular profile of plaques. Subjects:In this study we enrolled 18 consecutive patients undergoing carotid endoarterectomy, with homogeneus or heterogeneous plaques, as established by Doppler-ultrasound and local pulse-wave velocity was assessed before surgery. Methods:In carotid plaque specimens, we evaluated inflammasome (NLRP3), Receptor Activator of Nuclear Factor κB (RANK) and its natural ligand (RANK-L), Osteoprotegerin (OPG), and other inflammatory and apoptotic molecules by Western Blotting and qPCR analysis. In addition, lipid peroxidation of arterial specimens was assessed by TBARS assay. Results:In heterogeneus plaques we observed increased OPG expression (p=0.04), positively correlated with lipid peroxidation values (r=0.511, p=0.03); increased levels of RANK (p=0.02), and other inflammatory and apoptotic molecules. RANK-L protein was augmented in homogeneus plaques (p=0.01) and correlated to ß-index (r=0.514, p=0.03) and PWV (r=0.525, p=0.03) values. Conclusions:Our data provide evidence that increased local PWV and ß-index might identify plaque evolution towards calcification.

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Interplay between arterial stiffness and diastolic function

Cited by 28 publications

References 51 publications

Relation Between LV Diastolic Function and Aortic Compliance as Assessed by Transthoracic Echo

Relation Between LV Diastolic Function and Aortic Compliance as Assessed by Transthoracic Echo

Impact of pulse pressure on left ventricular global longitudinal strain in normotensive and newly diagnosed, untreated hypertensive patients

RANK-L is a Potential Therapeutic Target in Homogeneous Atherosclerotic Plaques

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