Interplay Among Psychopathologic Variables, Personal Resources, Context-Related Factors, and Real-life Functioning in Individuals With Schizophrenia

Galderisi, Silvana; Rucci, Paola; Kirkpatrick, Brian; Mucci, Armida; Gibertoni, Dino; Rocca, Paola; Rossi, Alessandro; Bertolino, Alessandro; Strauss, Gregory P.; Aguglia, Eugenio; Bellomo, Antonello; Murri, Martino Belvederi; Bucci, Paola; Carpiniello, Bernardo; Comparelli, Anna; Cuomo, Alessandro; Berardis, Domenico De; Dell’Osso, Liliana; Fabio, Fabio Di; Franke, Barbara; Marchesi, Carlo; Monteleone, Palmiero; Montemagni, Cristiana; Orsenigo, Giulia; Pacitti, Francesca; Roncone, Rita; Santonastaso, Paolo; Siracusano, Alberto; Vignapiano, A.; Vita, Antonio; Zeppegno, Patrizia; Maj, Mario

doi:10.1001/jamapsychiatry.2017.4607

Cited by 231 publications

(289 citation statements)

References 55 publications

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“…For instance, the Italian Network for Research on Psychoses (Rocca et al, 2016) identified clusters of patients according to their social cognition performances, the cluster consisting of the most impaired being the individuals with the worst symptomatic pattern in neurocognition, disorganization, and positive symptoms. The same group (Galderisi et al, 2018) lately confirmed via a network analysis that social cognition is nearer to the core of schizophrenia, than positive, negative, and disorganization symptoms are. Therefore, they suggested that improving everyday life skills and functional capacity, which strictly correlates with social cognition, is crucial for therapeutic interventions in schizophrenia.…”

Section: R E Le Va N Ce Of Soci a L C Ogn I Ti On I N S Ch I Zop H mentioning

confidence: 92%

Genetic and clinical features of social cognition in 22q11.2 deletion syndrome

Lattanzi

Buzzanca

Frascarelli

et al. 2018

J of Neuroscience Research

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22q11.2 deletion syndrome (22q11.2 DS) is widely known as one of the most compelling genetic models of schizophrenia so far, being almost 40% of the carriers affected by psychotic symptoms. Moreover, most of these subjects also show impairment in social cognition, which is a comprehensive array of function that guides social interaction with the others, leading as well to the acquisition of new cognitive and social skills. In the last decade researchers have argued whether social cognition dysfunctions could be underlined by specific genetic alterations, and whether these are linked to specific clinical features. Some valid candidate genes are RTN4R, that encodes a protein which inhibits axonal sprouting, DGCR8, crucial in mRNA processing, or catechol-O-methyltransferase (COMT) and proline oxydase 1 (PRODH), involved in catecholamine metabolism in frontal cortex. This is the first article to address the topic of social cognition in 22q11.2 DS from a wide perspective, with a highlight on its genetic characteristics. We will provide a narrative review of the most recent findings and we will point out new directions on this research path, in order to achieve an effective characterization of the neurobiological system underlying social behavior.

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Section: R E Le Va N Ce Of Soci a L C Ogn I Ti On I N S Ch I Zop H mentioning

confidence: 92%

Genetic and clinical features of social cognition in 22q11.2 deletion syndrome

Lattanzi

Buzzanca

Frascarelli

et al. 2018

J of Neuroscience Research

Self Cite

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“…A recent work from the Italian Network for Research on Psychoses (Galderisi et al, ), which is an example of what insight with potential treatment implications network analysis can provide into the complex relationships among symptoms, showed how functional capacity and everyday life skills play a central role in the network of symptoms and suggested that, alongside with pharmacologic treatment, “the ability to perform tasks relevant to everyday life is critical for any therapeutic intervention in schizophrenia.” Hence, identifying central nodes can help in identifying core domains to focus treatment on (Fried et al, ; Galderisi et al, ).…”

Section: Introductionmentioning

confidence: 99%

Network analysis of specific psychopathology and psychiatric symptoms in patients with anorexia nervosa

Solmi

Collantoni

Meneguzzo

et al. 2018

Euro Eating Disorders Rev

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“…Poor compliance or discontinuation of therapy have been shown to lead to relapses and hospitalizations [9][10][11] . Functional capability and skills used in everyday life are important factors impacting schizophrenia treatment adherence 12,13 .…”

Section: Introductionmentioning

confidence: 99%

Treatment discontinuation of long-acting injectables or oral atypical antipsychotics among Medicaid recipients with schizophrenia

Song

Khoury

Brouillette

et al. 2019

Journal of Medical Economics

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Aims: Among patients with schizophrenia, poor adherence and persistence with oral atypical antipsychotics (OAA) often results in relapse and hospitalization. Second-generation antipsychotic long-acting injectables (SGA LAI) have demonstrated higher adherence than first-generation antipsychotic LAI and OAA therapies. This study aimed to determine whether SGA LAIs are associated with better persistency compared to OAA among Medicaid recipients with schizophrenia. ), patients aged 18 years with schizophrenia and 2 pharmacy claims more than 90 days apart for the same SGA LAI or OAA were selected. New users of the specific antipsychotic agent were classified, based on their index agent, as: OAA, paliperidone palmitate LAI (PPLAI), aripiprazole LAI (ALAI), and risperidone LAI (RLAI). Discontinuation during 1 year of follow-up was defined as a 60-day gap in the index OAA or SGA LAI medication past the exhaustion of the previous claim's supply. Inverse probability of treatment weights (IPTW) balanced the cohort characteristics, and weight outliers (<0.1 or >0.9) were excluded. IPTW-weighted Cox proportional hazards regression estimated hazard ratios for discontinuation. Results: Cohorts included 7,029 OAA, 4,302 PPLAI, 586 ALAI, and 1,456 RLAI patients. Mean age was 38.0-41.0 years and 44.0-46.6% were female. Persistence was significantly longer in the SGA LAI cohorts than in the OAA cohort. Adjusted hazard ratios (95% confidence intervals) for discontinuation were 0.60 (0.56-0.64) for PPLAI, 0.69 (0.60-0.79) for ALAI, and 0.70 (0.64-0.77) for RLAI vs OAA. Limitations: Results may not be generalizable to patients covered by commercial or Medicare insurance, and limitations inherent to any claims-based retrospective analysis apply. Conclusions: SGA LAI may be a valuable option for treating schizophrenia given the improvement in persistence. ARTICLE HISTORY

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Interplay Among Psychopathologic Variables, Personal Resources, Context-Related Factors, and Real-life Functioning in Individuals With Schizophrenia

Cited by 231 publications

References 55 publications

Genetic and clinical features of social cognition in 22q11.2 deletion syndrome

Genetic and clinical features of social cognition in 22q11.2 deletion syndrome

Network analysis of specific psychopathology and psychiatric symptoms in patients with anorexia nervosa

Treatment discontinuation of long-acting injectables or oral atypical antipsychotics among Medicaid recipients with schizophrenia

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