Interplay Among Bacterial Resistance, Biofilm Formation and Oxidative Stress for Nosocomial Infections

Gabrani, Reema; Sharma, Garima; Dang, Shweta; Gupta, Sanjay

doi:10.1007/978-81-322-2035-0_23

Cited by 8 publications

(5 citation statements)

References 57 publications

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“…Usually, a healthy redox cycle promotes microbial attachment, thus favoring biofilm formation [ 39 ]. Inversely, in the presence of pro-oxidant compounds, a high level of ROS might favor a reduction of the extracellular polymeric substance (EPS) production, thus affecting the homogeneous structure, yeast numbers, and community composition of biofilm [ 46 , 47 , 48 ]. Recently, a strong association between oxidative stress and biofilm formation of bacteria and some yeast species has been demonstrated ( C. albicans , C. glabrata , C. krusei, and C. parapsilosis ) [ 47 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

Antifungal, Antioxidant and Antibiofilm Activities of Essential Oils of Cymbopogon spp.

et al. 2022

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Essential oils (EOs) of Cymbopogon citratus and Cymbopogon proximus are known as sources of monoterpenes and sesquiterpenoids, although their biological activities have not been well investigated. In this study, the compositions of C. citratus and C. proximus EOs of Egyptian origin and their antifungal and antibiofilm properties against Candida spp. and Malassezia furfur were investigated. Antioxidant activities were also evaluated. GC-MS showed the presence of nine and eight constituents in C. citratus and C. proximus EOs, respectively, with geranial and neral as the major compounds of C. citratus EO and piperitone and α-terpinolene as the major compounds of C. proximus EO. Both EOs showed antifungal (MIC values ranging from 1.25 to 20 µL/ mL) and antibiofilm activities (% of reduction ranging from 27.65 ± 11.7 to 96.39 ± 2.8) against all yeast species. The antifungal and antibiofilm activities of C. citratus EO were significantly higher than those observed for C. proximus EO. M. furfur was more susceptible to both EOs than Candida spp. Both EOs exhibited the highest antioxidant activity. This study suggests that C. citratus and C. proximus EOs might be an excellent source of antifungal, antibiofilm and antioxidant drugs and might be useful for preventing Malassezia infections in both medical and veterinary medicine.

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Section: Discussionmentioning

confidence: 99%

Antifungal, Antioxidant and Antibiofilm Activities of Essential Oils of Cymbopogon spp.

et al. 2022

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“…Antibiotics have high affinity to the targets if there is a single point of mutation could trigger the surface resulting in resistance and proliferation as well transfer of resistance gene by transformation. Enzyme catalysed inactivation of antibiotics by hydrolysis has been crucial reason for failure β lactam antibiotics preventing cell penetration, alteration of targets and resisting the action of antibiotics [7]. Formation of biofilms has been one of the major reasons for antibiotic failure.…”

Section: Antibiotic Resistancementioning

confidence: 99%

Omics based approach for biodiscovery of microbial natural products in antibiotic resistance era

Mohana

Rao

Rakshith

et al. 2018

Journal of Genetic Engineering and Biotechnology

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The need for a new antibiotic pipeline to confront threat imposed by resistant pathogens has become a major global concern for human health. To confront the challenge there is a need for discovery and development of new class of antibiotics. Nature which is considered treasure trove, there is re-emerged interest in exploring untapped microbial to yield novel molecules, due to their wide array of negative effects associated with synthetic drugs. Natural product researchers have developed many new techniques over the past few years for developing diverse compounds of biopotential. Taking edge in the advancement of genomics, genetic engineering, in silico drug design, surface modification, scaffolds, pharmacophores and target-based approach is necessary. These techniques have been economically sustainable and also proven efficient in natural product discovery. This review will focus on recent advances in diverse discipline approach from integrated Bioinformatics predictions, genetic engineering and medicinal chemistry for the synthesis of natural products vital for the discovery of novel antibiotics having potential application.

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“…However, within natural environments, bacteria often form complex communities that are densely integrated into a biofilm bound by extracellular polymeric substances. Biofilm bacteria have increased resistance to antimicrobials agents, due to exclusion of the antimicrobial, slow bacterial growth rates that impede antimicrobial activity and expression of secreted antimicrobial degrading products by some bacterial species within the community (Gabrani et al, 2015). Therapeutic doses of antimicrobials that are based on susceptibility levels obtained in vitro may not be effective against microbes encased within biofilms, resulting in treatment failure.…”

Section: Biofilm Inhibition and Dispersalmentioning

confidence: 99%

0495 Genomic approaches to characterizing and reducing antimicrobial resistance in beef cattle production systems

Javed

Klima

Cameron

et al. 2016

Journal of Animal Science

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Interplay Among Bacterial Resistance, Biofilm Formation and Oxidative Stress for Nosocomial Infections

Cited by 8 publications

References 57 publications

Antifungal, Antioxidant and Antibiofilm Activities of Essential Oils of Cymbopogon spp.

Antifungal, Antioxidant and Antibiofilm Activities of Essential Oils of Cymbopogon spp.

Omics based approach for biodiscovery of microbial natural products in antibiotic resistance era

0495 Genomic approaches to characterizing and reducing antimicrobial resistance in beef cattle production systems

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