“…Given our a priori focus on the social pain network, we investigated three neural regions of interest (ROIs) that have been implicated as reactive to social feedback in the form of exclusion, including the dACC, sgACC, and anterior insula (Eisenberger, ; Falk et al., ; Masten et al., , ; Sebastian et al., ; for a review, see Rotge et al., ). Adolescent girls were the focus of study given evidence for their heightened sensitivity to social cues (Guyer et al., ), greater emotional reactivity to social stressors (Rudolph, Flynn, Abaied, Groot, & Thompson, ; Rudolph, Lansford, & Rodkin, ; Shih, Eberhart, Hammen, & Brennan, ), including family disturbances (Davies & Windle, ; Rudolph & Flynn, ), and elevated risk for depressive symptoms (Rudolph, ). We predicted that stressful parent–child relationships would be associated with particularly high levels of subsequent depressive symptoms, whereas supportive parent–child relationships would be associated with particularly low levels of subsequent depressive symptoms in girls who showed heightened neural sensitivity to social cues.…”