Interpersonal prosodic correlation in frontotemporal dementia

Pressman, Peter; Ross, Elliott D.; Cohen, K. Bretonnel; Chen, Kuan‐Hua; Miller, Bruce L.; Hunter, Lawrence; Gorno‐Tempini, Maria Luisa; Levenson, Robert W.

doi:10.1002/acn3.50816

Cited by 7 publications

(5 citation statements)

References 16 publications

(19 reference statements)

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“…However, the Greek patient populations with mxPPA, lvPPA, and svPPA had no significant reduction in speech rate (Karpathiou & Kambanaros, 2022; Potagas et al, 2022). Some English patient populations with lvPPA, svPPA, and bvFTD also had no significant differences in speech rate (Ash et al, 2013; Bird et al, 2000; Mack et al, 2015; Marcotte et al, 2017; Pressman et al, 2019; Rohrer & Warren, 2010; Sajjadi et al, 2012; Thompson, 2012; Wilson et al, 2010). Aside from Greek, all other non-English languages (Spanish, Italian, Hindi, and Czech) studying the FTD spectrum had a significant reduction in speech rate (Catricala et al, 2019; Daoudi et al, 2022; Matias-Guiu et al, 2022; Sachin et al, 2008; Silveri et al, 2012).…”

Section: Resultsmentioning

confidence: 94%

A Systematic Review of the Quantitative markers of speech and language of the Frontotemporal Degeneration Spectrum and their potential for cross-linguistic implementation

Coppieters,

Bouzigues,

Jiskoot

et al. 2024

Preprint

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Frontotemporal dementia (FTD) is a neurodegenerative disease spectrum with an urgent need for reliable biomarkers for early diagnosis and monitoring. Speech and language changes occur in the early stages of FTD and offer a potential non-invasive, early, and accessible diagnostic tool. The use of speech and language markers in this disease spectrum is limited by the fact that most studies investigate English-speaking patients. This systematic review examines the literature on psychoacoustic and linguistic features of speech that occur across the FTD spectrum across as many different languages as possible. 76 papers were identified that investigate psychoacoustic and linguistic markers in discursive speech. 75% of these papers studied English-speaking patients. The most generalisable features found across different languages, are speech rate, articulation rate, pause frequency, total pause duration, noun: verb ratio, and total number of nouns. While there are clear interlinguistic differences across patient groups, the results show promise for implementation of cross-linguistic markers of speech and language across the FTD spectrum, particularly for psychoacoustic features.

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Section: Resultsmentioning

confidence: 94%

A Systematic Review of the Quantitative markers of speech and language of the Frontotemporal Degeneration Spectrum and their potential for cross-linguistic implementation

Coppieters,

Bouzigues,

Jiskoot

et al. 2024

Preprint

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“…These conflicting results might be due to the use of a different task (conversational speech) and measure (coefficient of variation of f0) of prosody and a smaller sample size of patients with sbvFTD than in this study. 38 Clinically differentiating patients with sbvFTD and svPPA can remain challenging, 39 especially at the individual level, and only a few clinical markers have been previously reported as discriminant in group-level analyses, specifically naming, repetition, and word comprehension (worse in svPPA) and empathy, emotion reading, difficulty identifying known people, and visuospatial abilities (worse in sbvFTD). 40 Expressive prosody may therefore represent an additional tool in clinical settings to better differentiate these 2 syndromes: a combination of several clinical markers might be optimal in differentiating patients with sbvFTD at the individual level in clinical practice, not only with patients with svPPA but also with patients with bvFTD.…”

Section: Discussionmentioning

confidence: 99%

Expressive Prosody in Patients With Focal Anterior Temporal Neurodegeneration

Geraudie,

Pressman,

Pariente

et al. 2023

Neurology

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Introduction:Progressive focal anterior temporal lobe (ATL) neurodegeneration has been historically called semantic dementia. More recently, semantic variant primary progressive aphasia (svPPA) and semantic behavioral variant frontotemporal dementia (sbvFTD) have been linked with predominant left or right ATL neurodegeneration, respectively. Nonetheless, clinical tools for accurate diagnosis of sbvFTD are still lacking. Expressive prosody refers to the modulation of pitch, loudness, tempo, and quality of voice used to convey emotional and linguistic information and has been linked to bilateral but right-predominant frontotemporal functioning. Changes in expressive prosody can be detected with semi-automated methods and could represent a useful diagnostic marker of socio-emotional functioning in sbvFTD.Methods:Participants underwent a comprehensive neuropsychological and language evaluation and a 3T MRI at UCSF. Each participant provided a verbal description of the picnic scene from the Western Aphasia Battery. The fundamental frequency (f0) range, an acoustic measure of pitch variability, was extracted for each participant. We compared the f0 range between groups and investigated associations with an informant-rated measure of empathy, a facial emotion labelling task, and gray matter volumes using voxel-based morphometry.Results:Twenty-eight patients with svPPA, 18 with sbvFTD, and 18 healthy controls (HC) were included. f0 range was significantly different across groups: sbvFTD patients showed reduced f0 in comparison to both patients with svPPA (mean difference of -1.4±2.4 semitones; 95% CI [-2.4, -0.4];p< .005), and HC (mean difference of -1.9±3.0 semitones; 95% CI [-3.0, -0.7];p< .001). f0 range was significantly positively correlated with informant-rated empathy (r= .355;p≤ .05), but not facial emotion labelling. Finally, the f0 range was significantly correlated with gray matter volume in the right superior temporal gyrus, encompassing anterior and posterior portions (p< .05 FWE cluster corrected).Conclusion:Expressive prosody may be a useful clinical marker of sbvFTD. Reduced empathy is a core symptom in sbvFTD; the present results extend this to prosody, a core component of social interaction, at the intersection of speech and emotion. They also inform the long-standing debate on the lateralization of expressive prosody in the brain, highlighting the critical role of the right superior temporal lobe.

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“…Fewer studies have assessed prosody during speech production in bvFTD. These studies showed reduced stress (Vogel et al, 2017), mixed results for pitch modulation (altered in Nevler et al, 2017but preserved in Pressman et al, 2019and Vogel et al, 2017, and preserved intensity (Pressman et al, 2019).…”

Section: Prosodymentioning

confidence: 92%

“…Despite partly contradictory evidence (Vogel et al, 2017), speech rate seems globally preserved in bvFTD (Ash et al, 2013;Gunawardena et al, 2010;Pressman et al, 2019;Wilson et al, 2010). Indeed, even in the infrequent reports showing decreased speech rate, this deficit disappears upon excluding long pauses (Ash et al, 2016).…”

Section: Motor Speech Through Connected Speechmentioning

confidence: 99%