Resistance to change can be the cause of difficulty when it is either too strong or too weak. Therapy or information can be used to either strengthen or weaken resistance to change to appropriate levels. The purpose of this article is intended to disclose the relationship between resistance to change and some aspects of human behavior. Resistance to change has affective, cognitive, and behavioral components that create a psychological resistance to making a change in particular situations or overall changes in one's life, and often appears in psychotherapy and/or when organizational alterations are underway. Four subfactors of resistance to change have been found and are related to extraversion and neuroticism in the “Big Five” personality model. Much indicates that the development of resistance to change begins early in childhood and may be neurophysiologically founded. It can be traced in both macro and micro gestures in body language and is believed to influence general health. Whereas previously published studies on resistance to change have mainly dealt with the effect of psychotherapy and/or re-organization of staff members in organizations, this analysis will show different areas in human thought, behavior, and situations where resistance can appear, and it will try to analyze what is behind the mechanism of resistance to change.