Interpenetrating polymer networks of poly(methacrylic acid) and polyacrylamide: synthesis, characterization and potential application for sustained drug delivery

Simeonov, Marin; Kostova, Bistra; Vassileva, Elena

doi:10.1039/c6ra14067j

Cited by 6 publications

(12 citation statements)

References 14 publications

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“…The procedure to obtain IPNs of PAA/PAAM and PMAA/PAAM is described elsewhere . Briefly, a two‐stage sequential method was applied.…”

Section: Methodsmentioning

confidence: 99%

“…The VPM loading and release were described elsewhere . Briefly, dry disk‐shaped samples with diameter of 8 mm were immersed in water solution of VPM with concentration 100 mg/mL, at temperature 24 ± 1 °C.…”

Section: Methodsmentioning

confidence: 99%

“…The tuning of the IPNs composition through varying the PAA/PAAM ratio allowed for modifying the VPM release profile. The best sustained release profile was observed for the IPN with the highest PAAM content: no initial burst effect occurred and ∼90% of the drug VPM was released for over 25 h. We have widen up our study by the synthesis of similar IPNs comprising the same side groups but replacing the PAA with poly(methacrylic acid) (PMAA) and applied these new systems for the VPM sustained release . The replacement of PAA with PMAA has changed the swelling ability of the IPNs due to the enhanced hydrophobicity of the latter, which has influenced the VPM release profile …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Drug transport in stimuli responsive acrylic and methacrylic interpenetrating polymer networks

Simeonov

Monova

Kostova

et al. 2017

J of Applied Polymer Sci

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The interpenetrating polymer networks (IPNs) are recently gaining attention as sustained drug delivery systems because they could ensure a proper combination of functionality and network density to control the drug release profiles. This study aims to reveal how the functionality of two IPNs based on polyacrylamide and respectively poly(acrylic acid) (PAA) and poly(methacrylic acid) (PMAA) influences their smart behavior as well as their properties as delivery systems of the cationic drug verapamil hydrochloride (VPM). The "extra" a-methyl group of PMAA results into a loss of the temperature sensitivity in the studied region and changes the pH responsivity of the PMAA/PAAM IPNs as compared to the PAA/PAAM IPNs. Moreover, the VPM diffusion in both IPNs depends on their composition due to the change in their functionality as well as of their network density. The "extra" a-methyl group of PMAA defines its enhanced hydrophobicity and hence influences the VPM diffusion mechanism.

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“…The procedure to obtain IPNs of PAA/PAAM and PMAA/PAAM is described elsewhere . Briefly, a two‐stage sequential method was applied.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Drug transport in stimuli responsive acrylic and methacrylic interpenetrating polymer networks

Simeonov

Monova

Kostova

et al. 2017

J of Applied Polymer Sci

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“…13 Sustained release of drugs from various materials such as hybrid polymers, composites and hydrogels in the form of bulk material or nanocarriers have been reported. [15][16][17][18][19][20][21][22] For example, two-component system from adamantane-modied and cyclodextrin modied hyaluronic acid were designed to prepare injectable hydrogels for sustained release of small molecules. 18 In another report, vincristine, hydrophobic and commonly used chemotherapeutic agent, was encapsulated within a peptide hydrogel and vincristine was shown to release constantly over the course of one month.…”

Section: Introductionmentioning

confidence: 99%

P2X7 receptor antagonist delivery vehicle based on photocrosslinked amphiphilic hybrid gels

Aydın

Kızılel

2018

RSC Adv.

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We report here a method for the synthesis of a unique hybrid gel system for the sustained delivery of P2X7 receptor (P2X7R) antagonist. P2X7R has been reported as a key mediator in inflammatory processes and controlled delivery of this molecule would be critical for the treatment of inflammatory arthritis. The hybrid gel designed here for the sustained delivery of P2X7R antagonists is based on crosslinked hydrophobic styrene-butadiene-styrene (SBS) polymer as a continuous network, where hydrogel particles prepared with hydrophilic poly(ethylene glycol) (PEG) were embedded into this system. PEG hydrogel particle-incorporated SBS gels were characterized through electron microscopy, water contact angle observations, and strong mechanical properties were confirmed through nanoindentation measurements. The release of P2X7R antagonist from these hybrid hydrogel-elastomer system demonstrated a sustained drug release profile up to 28 days at physiological pH, which was not observed in earlier reports. We obtained drug release percentages ranging from 49.72% to 93.04% which indicated the tunability of release through SBS crosslinking and hydrophilic/hydrophobic nature of SBS.This tunability is significant to achieve simultaneous improvements in drug efficacy with reduced side effects. CellTiter-Glo luminescence measurements using human kidney cells revealed that these networks are non-toxic and highly biocompatible with percent cell viabilities of higher than 85%. The approach presented here with crosslinked, amphiphilic and elastic SBS gel systems is not only promising for extended release of P2X7R antagonist but could also allow for incorporation of different molecules so that simultaneous/sequential and extended release profiles for therapeutic molecules could be achieved. Fig. 2 Light microscope images of PEG-cyclohexanone (4 ¼ 0.25) water in oil silica nanoparticle (1.5%) stabilized Pickering emulsions prepared by vortex times of (a) 30 s, (b) 60 s, (c) 2 min, (d) 8 min.

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“…Polyacrylamide (PAM) has good flocculation property, surface activity, and thickening performance, which result in its broad applications in wastewater treatment, papermaking, and drug delivery. [21][22][23] Poly(methacrylic acid) (PMAA) contains lots of carboxyl groups and has strong combination ability with metal ion. 24 Our group had synthesized PAM via electrochemically mediated ATRP with Cu(II)/2,2'-bipyridine as catalyst for the detection of Pb 21 .…”

Section: Introductionmentioning

confidence: 99%

Preparation of block copolymers via metal‐free visible‐light‐induced ATRP for the detection of lead ions

Sun

Zhao

et al. 2017

J of Applied Polymer Sci

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Polyacrylamide‐b‐poly(methacrylic acid) was prepared on the surface of Au electrode (Au/PAM/PMAA) for Pb2+ ion electrochemical sensing via metal‐free visible‐light‐induced atom transfer radical polymerization, which was very simple, convenient, and environmentally friendly. Au/PAM/PMAA was carefully examined by cyclic voltammetry, electrochemical impedance spectroscopy, and X‐ray photoelectron spectroscopy. Further, Au/PAM/PMAA was successfully used for the determination of Pb2+ ion by differential pulse anodic stripping voltammetry. Under the optimal conditions, a linear response from 1.0 × 10−11 to 1.0 × 10−4 mol/L with detection limit of 2.5 × 10−12 mol/L (S/N = 3) was achieved from the results of experiments. Comparing with similar Pb2+ sensors, the broader linear range and lower detection limit suggested the promising prospect of Au/PAM/PMAA. In a word, the work of this article had an important significance for the polymer‐modified electrodes and the sensitive detection of Pb2+. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45863.

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Interpenetrating polymer networks of poly(methacrylic acid) and polyacrylamide: synthesis, characterization and potential application for sustained drug delivery

Cited by 6 publications

References 14 publications

Drug transport in stimuli responsive acrylic and methacrylic interpenetrating polymer networks

Drug transport in stimuli responsive acrylic and methacrylic interpenetrating polymer networks

P2X7 receptor antagonist delivery vehicle based on photocrosslinked amphiphilic hybrid gels

Preparation of block copolymers via metal‐free visible‐light‐induced ATRP for the detection of lead ions

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