Interosseous electrostimulation in a model of lengthening with external fixation

Peña‐Martínez, Víctor M.; Lara‐Arias, Jorge; Vílchez-Cavazos, Félix; Álvarez-Lozano, Eduardo; Oca‐Luna, Roberto Montes de; O, Mendoza-Lemus

doi:10.1016/j.circen.2017.02.009

Cited by 2 publications

(2 citation statements)

References 31 publications

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“…The obtained results revealed that AC stimulation accelerated the maturation of lengthened callus radiologically, electro-physiologically and histologically, which shorten the time course of callus formation ( Kawamoto et al, 2005 ). Moreover, according to Peña-Martínez et al’ study, a significant difference in the bone density and callus formation between experimental group and control group was obtained, which demonstrated the effectiveness of AC stimulation during bone elongation can speed up the consolidation process in animal model ( Peña-Martínez et al, 2017 ). Despite the widespread use of electromagnetic stimulation in orthopaedics, there is no definitive clinical data support its use in DO or bone lengthening.…”

Section: Introductionmentioning

confidence: 88%

Overview of Physical and Pharmacological Therapy in Enhancing Bone Regeneration Formation During Distraction Osteogenesis

Liu

Guo

et al. 2022

Front. Cell Dev. Biol.

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Distraction osteogenesis (DO) is a kind of bone regeneration technology. The principle is to incise the cortical bone and apply continuous and stable distraction force to the fractured end of the cortical bone, thereby promoting the proliferation of osteoblastic cells in the tension microenvironment and stimulating new bone formation. However, the long consolidation course of DO presumably lead to several complications such as infection, fracture, scar formation, delayed union and malunion. Therefore, it is of clinical significance to reduce the long treatment duration. The current treatment strategy to promote osteogenesis in DO includes gene, growth factor, stem-cell, physical and pharmacological therapies. Among these methods, pharmacological and physical therapies are considered as safe, economical, convenience and effective. Recently, several physical and pharmacological therapies have been demonstrated with a decent ability to enhance bone regeneration during DO. In this review, we have comprehensively summarized the latest evidence for physical (Photonic, Waves, Gas, Mechanical, Electrical and Electromagnetic stimulation) and pharmacological (Bisphosphonates, Hormone, Metal compounds, Biologics, Chinese medicine, etc) therapies in DO. These evidences will bring novel and significant information for the bone healing during DO in the future.

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Section: Introductionmentioning

confidence: 88%

Overview of Physical and Pharmacological Therapy in Enhancing Bone Regeneration Formation During Distraction Osteogenesis

Liu

Guo

et al. 2022

Front. Cell Dev. Biol.

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“…Имеющиеся к настоящему времени экспериментальные работы демонстрируют положительный остеогенный эффект электростимуляции с использованием спиц аппарата Илизарова в качестве электродов, в частности на модели дистракционного остеогенеза [46,47,48,49]. Во всех случаях стимулирующий эффект достигался за счет более ранней минерализации дистракционного регенерата на этапе фиксации, в связи с чем оптимальными сроками электростимуляции являются последние дни дистракции и первые дни фиксации.…”

Section: таблица работы с доказанным эффектом стимуляции дифференцироunclassified

Stimulation of Osteogenesis by Direct Electric Current (Review)

Овчинников

Stogov

2019

Traumatology and Orthopedics of Russia

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Background. Stimulation of osteogenesis in the treatment of certain orthopedic and trauma pathologies is a necessary element to ensure the best clinical outcome. The purpose of the present analytical review is to analyze the literature data in respect of evaluating the approaches and possibilities to stimulate osteogenesis using direct current. Methods. The search for literature data was performed in the open electronic databases of scientific literature PubMed and eLIBRARY under the following keywords and their combinations: “osteogenesis”, “reparative osteogenesis”, “direct electric current”, “orthopaedics”, “traumatology”, “electric current” (in Russian as well as in English language ). Results. According to some fundamental research, the stimulating effect of direct current lies is both in stimulating differentiation and proliferation of osteoblasts, and in stimulating differentiation of stem cells, mainly mesenchymal stem cells of bone marrow and adipose tissue, in the process of osteogenesis. The following stimulating technologies were developed and clinically tested to date: 1 — direct exposure of bone to the direct current; 2 — capacitive coupled stimulation; and 3 — inductive coupled (electromagnetic) stimulation. Analysis of clinical practice demonstrated that the first technology is most effective in terms of osteoreparation, but less safe than technology 2 and 3. It should be noted that there are no clear indications and modes of application for the abovementioned methods. Based on the data collected in the present analysis, technology 1 is considered by authors as the most promising. Safety of technology 1 can be enhanced by application of metal implants as electrodes in case those are planned to be used for medical reasons: wires, rods, staples, fixators, etc. Conclusion. Use of electric current to stimulate bone formation is a promising method which requires clarification in respect of indications and application modes.

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Interosseous electrostimulation in a model of lengthening with external fixation

Cited by 2 publications

References 31 publications

Overview of Physical and Pharmacological Therapy in Enhancing Bone Regeneration Formation During Distraction Osteogenesis

Overview of Physical and Pharmacological Therapy in Enhancing Bone Regeneration Formation During Distraction Osteogenesis

Stimulation of Osteogenesis by Direct Electric Current (Review)

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