Interocular transfer of shape discrimination in the goldfish—A reassessment of the role of the posterior commissure

Hemsley, J. Paul; Savage, George E.

doi:10.1016/0014-4886(87)90274-3

Cited by 4 publications

(1 citation statement)

References 7 publications

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“…nTPC neurons lie at the posterior dorsal diencephalon and are described as being intermixed with MTN neurons in a number of amniotes (Noden, ; Mastick and Easter, ). They form in the dorsal posterior diencephalon at the same time as MTN neurons and their axons grow ventrally, contributing to the tract of the posterior commissure and in goldfish innervate prectectal areas, the dorsal thalamus and optic tectum (Hemsley and Savage, ; Easter et al, ; Mastick and Easter, ; Dyer et al, ). We have previously shown that MTN and nTPC neurons form in different components of the brain (mesencephalon compared to diencephalon) and that it is possible to discriminate between them.…”

Section: Introductionmentioning

confidence: 99%

Specification of sensory neurons occurs through diverse developmental programs functioning in the brain and spinal cord

Dyer

Linker

Graham

et al. 2014

Developmental Dynamics

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Background: Vertebrates possess two populations of sensory neurons located within the central nervous system: Rohon-Beard (RB) and mesencephalic trigeminal nucleus (MTN) neurons. RB neurons are transient spinal cord neurons whilst MTN neurons are the proprioceptive cells that innervate the jaw muscles. It has been suggested that MTN and RB neurons share similarities and may have a common developmental program, but it is unclear how similar or different their development is. Results: We have dissected RB and MTN neuronal specification in zebrafish. We find that RB and MTN neurons express a core set of genes indicative of sensory neurons, but find these are also expressed by adjacent diencephalic neurons. Unlike RB neurons, our evidence argues against a role for the neural crest during MTN development. We additionally find that neurogenin1 function is dispensable for MTN differentiation, unlike RB cells and all other sensory neurons. Finally, we demonstrate that, although Notch signalling is involved in RB development, it is not involved in the generation of MTN cells. Conclusions: Our work reveals fundamental differences between the development of MTN and RB neurons and suggests that these populations are non-homologous and thus have distinct developmental and, probably, evolutionary origins.

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