Interocular transfer of preoperatively trained visual discriminations in goldfish (Carassius auratus) following selective commissure transections

Hemsley, J. Paul; Savage, George E.

doi:10.1016/s0166-4328(89)80062-2

Cited by 2 publications

(2 citation statements)

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“…Behavioural studies in goldfish, pigeons and primates have consistently revealed that these commissures are involved in contralateral transfer of visually learned information (Black and Myers, 1964;Sullivan and Hamilton, 1973;Risse et al, 1978;Francesconi et al, 1982;Hemsley and Savage, 1989).…”

Section: Introductionmentioning

confidence: 99%

Frizzled-3a and Wnt-8b genetically interact during forebrain commissural formation in embryonic zebrafish

Hofmeister

Key

2013

Brain Research

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Number of words: 3225Key words: Wnt8b, Fzd3a, axon guidance, commissure, zebrafish, slit2Keyfindings:• Knockdown of Wnt8b results in an absence of the anterior commissure and a reduction of the post-optic commissure • Knockdown of Wnt8b results in a expansion of slit2 at the rostral midline and a reduction of the glial bridge • The phenotype observed following knockdown of Wnt8b is similar to that seen following knockdown of Fzd3a • Combined loss of both Wnt8b and Fzd3a caused a synergistic increase in commissural defects and abnormal slit2 expression • Fzd3a and Wnt8b act in the same genetic pathway to control normal patterning of the commissural plate Acknowledgements: This work was supported by grants from NHMRC and ARC to B.K.2 AbstractThe commissural plate forms the rostral surface of the embryonic vertebrate forebrain and provides a cellular substrate for forebrain commissural axons. We have previously reported that the Wnt receptor frizzled-3a (fzd3a) restricts the expression of the chemorepulsive guidance ligand slit2 to a discrete domain of neuroepithelial cells in the commissural plate of embryonic zebrafish. Loss-of-Fzd3a function perturbed slit2 expression and disrupted the formation of glial bridges which guide the formation of forebrain commissures. We now show that Wnt8b is also necessary for anterior commissural formation as well as for patterning of slit2 expression at the midline. Knock down of Wnt8b produced the same phenotype as loss of Fzd3a which suggested that these genes were acting together to regulate axon guidance. Simultaneous sub-threshold knock down of both Fzd3a and Wnt8b led to a greater than additive increase in the penetrance of the mutant phenotype which indicated that these two genes were indeed interacting. We have shown here that Fzd3a/Wnt8b signaling is essential for normal patterning of the commissural plate and that loss-of-function in either receptor or ligand causes Slit2-dependent defects in glial bridge morphology which indirectly attenuated axon midline crossing in the embryonic vertebrate forebrain.3

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Section: Introductionmentioning

confidence: 99%

Frizzled-3a and Wnt-8b genetically interact during forebrain commissural formation in embryonic zebrafish

Hofmeister

Key

2013

Brain Research

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“…The left and right TeO modulate their activity patterns via the tectal (CT) and the posterior commissures (CP) (Robert and Cuénod, ; Niida, ; Mascetti and Arriagada, ; Rhoades et al, ; Keysers et al, ). These commissures have been implicated in interhemispheric transfer of visual discriminations in fish (Mark, ; Ingle and Campbell, ; Hemsley and Savage, ), in transfer of habituated stimuli and in lateralized visuomotor behavior in birds (Hamassaki and Britto, ; Güntürkün and Böhringer, ), and in transfer of black–white discrimination, recovery from cortical hemianopia, and to some extent transfer of motion and brightness discrimination in mammals (Sherman, ; Peck et al, ; Hottman, ; Sprague, ).…”

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confidence: 99%

A GABAergic tecto–tegmento–tectal pathway in pigeons

Stacho

Letzner

Theiß

et al. 2016

J of Comparative Neurology

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Previous studies have demonstrated that the optic tecta of the left and right brain halves reciprocally inhibit each other in birds. In mammals, the superior colliculus receives inhibitory γ-aminobutyric acid (GABA)ergic input from the basal ganglia via both the ipsilateral and the contralateral substantia nigra pars reticulata (SNr). This contralateral SNr projection is important in intertectal inhibition. Because the basal ganglia are evolutionarily conserved, the tectal projections of the SNr may show a similar pattern in birds. Therefore, the SNr could be a relay station in an indirect tecto-tectal pathway constituting the neuronal substrate for the tecto-tectal inhibition. To test this hypothesis, we performed bilateral anterograde and retrograde tectal tracing combined with GABA immunohistochemistry in pigeons. Suprisingly, the SNr has only ipsilateral projections to the optic tectum, and these are non-GABAergic. Inhibitory GABAergic input to the contralateral optic tectum arises instead from a nearby tegmental region that receives input from the ipsilateral optic tectum. Thus, a disynaptic pathway exists that possibly constitutes the anatomical substrate for the inhibitory tecto-tectal interaction. This pathway likely plays an important role in attentional switches between the laterally placed eyes of birds. J. Comp. Neurol. 524:2886-2913, 2016. © 2016 Wiley Periodicals, Inc.

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Interocular transfer of preoperatively trained visual discriminations in goldfish (Carassius auratus) following selective commissure transections

Cited by 2 publications

References 10 publications

Frizzled-3a and Wnt-8b genetically interact during forebrain commissural formation in embryonic zebrafish

Frizzled-3a and Wnt-8b genetically interact during forebrain commissural formation in embryonic zebrafish

A GABAergic tecto–tegmento–tectal pathway in pigeons

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