Interoceptive regulation of skeletal tissue homeostasis and repair

Abstract

Recent studies have determined that the nervous system can sense and respond to signals from skeletal tissue, a process known as skeletal interoception, which is crucial for maintaining bone homeostasis. The hypothalamus, located in the central nervous system (CNS), plays a key role in processing interoceptive signals and regulating bone homeostasis through the autonomic nervous system, neuropeptide release, and neuroendocrine mechanisms. These mechanisms control the differentiation of mesenchymal stem cells into osteoblasts (OBs), the activation of osteoclasts (OCs), and the functional activities of bone cells. Sensory nerves extensively innervate skeletal tissues, facilitating the transmission of interoceptive signals to the CNS. This review provides a comprehensive overview of current research on the generation and coordination of skeletal interoceptive signals by the CNS to maintain bone homeostasis and their potential role in pathological conditions. The findings expand our understanding of intersystem communication in bone biology and may have implications for developing novel therapeutic strategies for bone diseases.

Ginsenoside Rb2 exhibits therapeutic value for male osteoporosis in orchiectomy mice by suppressing osteoclastogenesis and modulating NF-κB/MAPK signaling pathways

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MRI and Single-cell RNA Sequence Results Reveal the Influence of Anterior Talofibular Ligament Injury on Osteochondral Lesions of the Talus

“…It lacks self-healing ability when damaged, and in clinical practice, it usually manifests as persistent ankle pain. 24,25 As the injury gradually worsens, it will affect the upper surface of the talus, causing greater and irreversible damage to the entire ankle joint. [26][27][28] There is a research report that by collecting CT and MRI data of patients with ATFL rupture and 2-month follow-up after Broström surgery, by establishing nite element model of the foot and ankle to simulate the stress on the ankle joint of patients with ATFL injury before and after surgery during normal gait cycles (landing phase, neutral phase, off ground phase).…”

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