Interobserver and intraobserver variability affecting the assessment of loss of autofluorescence of oral mucosal lesions

Pentenero, Monica; Todaro, Daniela; Marino, Roberto Luiz; Gandolfo, S

doi:10.1016/j.pdpdt.2019.09.007

Cited by 5 publications

(3 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Large prospective studies including studies evaluating the genetic changes and progression rates associated with the “AFV suspicious” sites can be carried out. [ 28 29 ]…”

Section: Discussionmentioning

confidence: 99%

Velscope guided oral cancer screening: A ray of hope in early oral cancer diagnosis

Vibhute

Jagtap

Patil

2021

J Oral Maxillofac Pathol

View full text Add to dashboard Cite

Context: Early oral cancer diagnosis is an important factor in reducing cancer-associated mortality and morbidity. Traditional oral cancer screening by Conventional Oral Examination (COE) is limited. A new approach in this regard is the use of “optical biopsy systems” like VELscope. Aims: Hence, this study aimed to determine the diagnostic value of VELscope, an autofluorescence-based handheld device in detection of dysplasia and oral squamous cell carcinoma (OSCC) in general oral potentially malignant disorder. Settings and Design: A prospective, cross-sectional study was conducted at a tertiary hospital in western Maharashtra, India. Materials and Methods: Thirty patients with presence of clinically suspicious oral lesions were included, and for each lesion, both the COE and Autofluorescence Examination by VELscope were carried out at the same appointment by different experts. All lesions were biopsied and histopathological findings were documented and analyzed. Statistical Analysis Used: Sensitivity, specificity, positive predictive value and negative predictive value were estimated to determine the accuracy of VELscope examination analysis outcome. Results: The study included a total of 30 subjects including 19 (63.33%) males and 11 (26.66%) females. Autofluorescence examination by VELscope (AFV) revealed Autofluorescence Loss in 24 (80%) patients, while 6 (20%) patients showed Autofluorescence Retained. Comparison between the “high-risk lesions” (moderate/severe dysplasia and OSCC) and “low-risk lesions” (no/mild dysplasia) showed a 90.47% sensitivity but only 44.44% specificity. Conclusions: The findings of our study indicate that although AFV cannot be a substitute for COE, it can be used as a potential complementary diagnostic aid in surveillance of the high-risk patient population.

show abstract

“…Large prospective studies including studies evaluating the genetic changes and progression rates associated with the “AFV suspicious” sites can be carried out. [ 28 29 ]…”

Section: Discussionmentioning

confidence: 99%

Velscope guided oral cancer screening: A ray of hope in early oral cancer diagnosis

Vibhute

Jagtap

Patil

2021

J Oral Maxillofac Pathol

View full text Add to dashboard Cite

show abstract

“…Standardized forms were used to collect all data. Diagnostic accuracy in terms of the diagnostic odds ratio (DOR), summary receiver operating characteristic (SROC) curve, and area under the SROC curve (AUCs), 1,3,6,12‐35 and the inter‐rater agreement of the autofluorescence analysis, 18,21,36 were analyzed. The screening performance of autofluorescence was compared with that of toluidine blue staining or clinical examination.…”

Section: Methodsmentioning

confidence: 99%

Autofluorescence imaging to identify oral malignant or premalignant lesions: Systematic review and meta‐analysis

Kim

Hwang

2020

Head & Neck

View full text Add to dashboard Cite

The aim is to evaluate the accuracy of autofluorescence for screening oral cancer in comparison with toluidine blue staining and clinical examination. Oral mucosal disorders detected by autofluorescence were compared with those detected using toluidine blue staining. Methodological quality was evaluated using the Quality Assessment of Diagnostic Accuracy Studies tool. The diagnostic odds ratio (DOR) for autofluorescence was 8.197 (95% confidence interval, 4.018-16.723). The area under the summary receiver operating characteristic curve (AUC) was 0.815. Compared with toluidine blue, autofluorescence had a similar sensitivity, negative predictive value, and AUC but a lower specificity and DOR. Compared with clinical examination, the autofluorescence had a higher sensitivity but lower specificity, DOR, and AUC. Although the diagnostic accuracy of autofluorescence in the screening work-up of oral cancer and precancer was more sensitive than those of clinical examination and toluidine blue staining, it was not accurate enough to be used alone reliably.

show abstract

“…[ 12 13 14 15 16 17 ] Despite this, there is a disagreement of various studies about its clinical effectiveness, and the diagnostic efficacy of this tool is still much debated in scientific and clinical medical literature. [ 18 19 20 ] The availability of such efficient and effective tools from this point of view could help the in the early diagnosis, and also improving the quality of life of the patient by timely intervention, and in some cases guaranteeing a longer survival term.…”

Section: Introductionmentioning

confidence: 99%

To Evaluate the Efficacy of Tissue Autofluorescence (Velscope) in the Visualization of Oral Premalignant and Malignant Lesions among High-Risk Population Aged 18 Years and Above in Haroli Block of Una, Himachal Pradesh

Sharma

Bansal

et al. 2022

Journal of International Society of Preventive and Community Dentistry

View full text Add to dashboard Cite

Interobserver and intraobserver variability affecting the assessment of loss of autofluorescence of oral mucosal lesions

Cited by 5 publications

References 25 publications

Velscope guided oral cancer screening: A ray of hope in early oral cancer diagnosis

Velscope guided oral cancer screening: A ray of hope in early oral cancer diagnosis

Autofluorescence imaging to identify oral malignant or premalignant lesions: Systematic review and meta‐analysis

To Evaluate the Efficacy of Tissue Autofluorescence (Velscope) in the Visualization of Oral Premalignant and Malignant Lesions among High-Risk Population Aged 18 Years and Above in Haroli Block of Una, Himachal Pradesh

Contact Info

Product

Resources

About